Sliding Blocks Revisited: A simulational Study

A computational study of sliding blocks on inclined surfaces is presented. Assuming that the friction coefficient $\mu$ is a function of position, the probability $P(\lambda)$ for the block to slide down over a length $\lambda$ is numerically calculated. Our results are consistent with recent experimental data suggesting a power-law distribution of events over a wide range of displacements when the chute angle is close to the critical one, and suggest that the variation of $\mu$ along the surface is responsible for this.Comment: 6 pages, 4 figures. submitted to Int. J. Mod. Phys. (Proc. Brazilian Wokshop on Simulational Physics

Akute Barbitalwirkungen auf den Protein- und Nucleinsäurestoffwechsel der Rattenleber

Peer Reviewe

Host responses to Renibacterium salmoninarum and specific components of the pathogen reveal the mechanisms of immune suppression and activation

During infection, Renibacterium salmoninarum survives within the pronephric macrophages of salmonid fish. Therefore, to study the initial phases of the interaction we infected macrophages with live bacteria and analysed the responses of host and pathogen. It was found that the expression of msa encoding the p57 antigen of R. salmoninarum, was constitutive, while the expression of hly and rsh, encoding haemolysins, and lysB and grp was reduced after infection. Macrophages showed a rapid inflammatory response in which the expression of interleukin-1β (IL-1β), major histocompatibility complex class II (MHC II), inducible cyclo-oxygenase (Cox-2), and inducible nitric oxide synthase (iNOS) was enhanced, but tumour necrosis factor-α (TNF-α) expression was greatly reduced initially and then increased. After 5 days, except for TNF-α and MHC II, expression returned to levels approaching those of uninfected macrophages. We propose that R. salmoninarum survives initial contact with macrophages by avoiding and/or interfering with TNF-α-dependent killing pathways. The effects of specific R. salmoninarum components were studied in vivo by injecting fish with DNA vaccine constructs expressing msa, hly, rsh, lysB, or grp. We found that msa reduced the expression of IL-1β, Cox-2, and MHC II but stimulated TNF-α while hly, rsh and grp stimulated MHC II but down-regulated TNF-α. Constructs expressing hly or lysB stimulated iNOS expression and additionally, lysB stimulated TNF-α. The results show how p57 suppresses the host immune system and suggest that the immune mechanisms for the containment of R. salmoninarum infections rely on MHC II- and TNF-α-dependent pathways. Moreover, prolonged stimulation of TNF-α may contribute to the chronic inflammatory pathology of bacterial kidney disease

The EUROclass trial: defining subgroups in common variable immunodeficiency

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification addressing pathogenic mechanisms as well as clinical relevance. This European multicenter trial was initiated to develop a consensus of 2 existing classification schemes based on flowcytometric B-cell phenotyping and the clinical course. The clinical evaluation of 303 patients with the established diagnosis of CVID demonstrated a significant coincidence of granulomatous disease, autoimmune cytopenia, and splenomegaly. Phenotyping of B-cell subpopulations confirmed a severe reduction of switched memory B cells in most of the patients that was associated with a higher risk for splenomegaly and granulomatous disease. An expansion of CD21(low) B cells marked patients with splenomegaly. Lymphadenopathy was significantly linked with transitional B-cell expansion. Based on these findings and pathogenic consideration of B-cell differentiation, we suggest an improved classification for CVID (EUROclass), separating patients with nearly absent B cells (less than 1%), severely reduced switched memory B cells (less than 2%), and expansion of transitional (more than 9%) or CD21(low) B cells (more than 10%). Whereas the first group contains all patients with severe defects of early B-cell differentiation, severely reduced switched memory B cells indicate a defective germinal center development as found in inducible constimulator (ICOS) or CD40L deficiency. The underlying defects of expanded transitional or CD21(low) B cells remain to be elucidated. This trial is re-gistered at http://www.uniklinik-freiburg.de/zks/live/ukiregister/Oeffentlich.html as UKF000308