Disorder effects at low temperatures in La_{0.7-x}Y_{x}Ca_{0.3}MnO_{3} manganites

With the aim of probing the effect of magnetic disorder in the low-temperature excitations of manganites, specific-heat measurements were performed in zero field, and in magnetic fields up to 9 T in polycrystalline samples of La_{0.7-x}Y_{x}Ca_{0.3}MnO_{3}, with Y concentrations x=0, 0.10, and 0.15. Yttrium doping yielded the appearance of a cluster-glass state, giving rise to unusual low-temperature behavior of the specific-heat. The main feature observed in the results is a strong enhancement of the specific-heat linear term, which is interpreted as a direct consequence of magnetic disorder. The analysis was further corroborated by resistivity measurements in the same compounds.Comment: 9 pages, 2 figure

MTSS1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients

Dentin Hypersensitivity Before and After Periodontal Treatment

Svrha: Želio se procijeniti intenzitet dentinske preosjetljivosti prije postupaka supragingivne i subgingivne instrumentacije i nakon njih. Materijal i metode: Bio je odabran prikladan uzorak od 200 ispitanika obaju spolova u dobi od 18 do 71 godine, a dijagnosticiran im je bio marginalni gingivitis, gingivna recesija i umjeren i/ili izrazit kronični parodontitis. Preosjetljivost je ustanovljena kliničkim pregledom te izmjerena mehanički provlačenjem sonde preko izloženog dentina i toplinskim podražajima – mlazom zraka iz pustera na osjetljivim područjima. Rezultati: Otkriveno je nekoliko vrsta preosjetljivosti kod istog pojedinca, a najčešća je bila preosjetljivost dentina u području korijena zuba. Najviše ispitanika bolovalo je od kroničnog parodontitisa, najčešće su imali više od pet preosjetljivih zuba, a povećana preosjetljivost bila je zabilježena nakon supragingivne i subgingivne instrumentacije. Sekundarni čimbenici koji su pojačavali osjetljivost i sve varijable vezane uz preosjetljivost, statistički su značajni (p<0,05). Zaključak: Preosjetljivost je česta kod pacijenata s parodontnom bolešću, a izraženija je nakon inicijalne parodontne terapije te kada je udružena s ostalim lokalnim čimbenicima.Objective: To evaluate the intensity of dentin hypersensitivity before and after the procedures of supragingival and subgingival instrumentation. Method: The convenience sample consisted of 200 patients of both genders, aged 18-71 years, who had chronic marginal gingivitis, gingival recession and moderate and/or severe chronic periodontitis. The hypersensitivity was diagnosed by clinical examination and measured by means of mechanical (dragging the probe over the exposed dentin) and thermal (air blast from a triple syringe) stimuli in sensitive areas. Results: The data revealed several types of hypersensitivity in the same individual, with the highest percentage in the tooth root; the largest percentage in the sample had chronic periodontitis; most patients had more than five hypersensitive teeth; increased hypersensitivity was found after supragingival and subgingival instrumentation; the presence of secondary factors exacerbating the sensitivity was recorded; and all variables associated with hypersensitivity had statistical significance (p <0.05). Conclusion: It is concluded that hypersensitivity is a common condition in patients with periodontal disease, which is more pronounced after initial periodontal therapy and when associated with other local factors

DeepTIO: a deep thermal-inertial odometry with visual hallucination

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordVisual odometry shows excellent performance in a wide range of environments. However, in visually-denied scenarios (e.g. heavy smoke or darkness), pose estimates degrade or even fail. Thermal cameras are commonly used for perception and inspection when the environment has low visibility. However, their use in odometry estimation is hampered by the lack of robust visual features. In part, this is as a result of the sensor measuring the ambient temperature profile rather than scene appearance and geometry. To overcome this issue, we propose a Deep Neural Network model for thermal-inertial odometry (DeepTIO) by incorporating a visual hallucination network to provide the thermal network with complementary information. The hallucination network is taught to predict fake visual features from thermal images by using Huber loss. We also employ selective fusion to attentively fuse the features from three different modalities, i.e thermal, hallucination, and inertial features. Extensive experiments are performed in hand-held and mobile robot data in benign and smoke-filled environments, showing the efficacy of the proposed model

Magnetic phases of the quasi-two-dimensional compounds FexCo1 - xTa2O6

International audienceWe report new results on the magnetic properties of the FexCo1 - xTa2O6 series of compounds. Essentially using neutron-diffraction and magnetic measurements we study, in more detail, the low-x limit of the temperature versus x phase diagram, where a new bicritical point is observed. The complete phase diagram shows three different magnetic phases at low temperature, for a high, intermediate and very low iron content. These phases consist of distinct antiferromagnetic orderings, characterized by different pairs of propagation vectors. We obtain information about the intraplane exchange interactions by fitting a high-temperature series of the magnetic susceptibility. Here we improve on a previously employed model, showing that two non-equivalent next-nearest-neighbor interactions must be taken into account in order to allow for in-plane magnetic orderings that are consistent with the neutron-diffraction results

Coronaviridae—Old friends, new enemy!

Coronaviridae is a family of single‐stranded positive enveloped RNA viruses. This article aimed to review the history of these viruses in the last 60 years since their discovery to understand what lessons can be learned from the past. A review of the PubMed database was carried out, describing taxonomy, classification, virology, genetic recombination, host adaptation, and main symptoms related to each type of virus. SARS‐CoV‐2 is responsible for the ongoing global pandemic, and SARS‐CoV and MERS‐CoV were responsible for causing severe respiratory illness and regional epidemics in the past while the four other strains of CoVs (229‐E OC43, NL63, and HKU1) circulate worldwide and normally only cause mild upper respiratory tract infections. Given the enormous diversity of coronavirus viruses in wildlife and their continuous evolution and adaptation to humans, future outbreaks would undoubtedly occur. Restricting or banning all trade in wild animals in wet markets would be a necessary measure to reduce future zoonotic infections

Differential Haematobia irritans infestation levels in beef cattle raised in silvopastoral and conventional pasture systems.

The use of silvopastoral systems (SPS) can be a good alternative to reduce the environmental impacts of livestock breeding in Brazil. One of the reasons for its scarce adoption is the lack of information on health and productivity of cattle raised under these conditions. The experiment reported here was designed to compare the infestation by external parasites ? the cattle tick (Rhipicephalus microplus), horn fly (Haematobia irritans), and larvae of the botfly (Dermatobia hominis) ? in beef cattle raised in a SPS and a conventional pasture system (CPS), evaluated for 24 months. Data on air and soil temperature, solar radiation, wind incidence and water balance were used to characterize the SPS and CPS. R. microplus adult females and D. hominis larvae were counted on the body of each animal to determine the parasites burdens, but we did not find significant differences between the two systems. Horn flies counts on animals? body, and analysis of the horn fly and its pupal parasitoids associated with the dung pats were obtained in the two systems. Horn fly infestation was significantly lower (p = 0.01) in the SPS (13.17 ± 3.46) in comparison with the CPS (24.02 ± 4.43). In SPS and CPS, respectively, the mean densities of pupae of H. irritansin dung pats were 9.8 and 10.7; the mean density of adults of H. irritans, 3.7 and 3.5; and the density of its pupal parasitoids were 20.5 and 5.4. The effect of production system was significant (p < 0.05) only for the occurrence of pupal parasitoids of the horn fly, where the greatest occurrences of these natural enemies were in the SPS. These data indicate that natural enemies were able to control, at least partially, the horn fly populations in the cattle

Are there differences between partial and total periodontal examination of the mouth?

Background: Diagnosis of periodontal disease for epidemiologic survey is difficult due to complexity of periodontal exam. The aim of this study was &nbsp;to compare data from a full-mouth examination and a partial-mouth examination, observing the agreement between both methods of presenting the Community Periodontal Index (CPI). Methods and Findings: The population comprised of male and female subjects, aged 18 years and over, attending public health centers in the city of Recife, Brazil. A total of 505 patients participated in this study. Each participant completed a form and underwent periodontal examination. Firstly, for each tooth present one of the periodontal conditions was determined: periodontal health, gingival bleeding, dental calculus, shallow periodontal pockets and deep periodontal pockets, according to CPI. Finally, partial data (10 index teeth) was recorded derived from the total version of CPI. Bivariate analysis of frequencies and means was performed. Mc Nemar test was used to calculate the level of statistical significance of the association tested. There are significant statistical differences between partial and full-mouth examination (p&lt;0.001). According to gender, men classified as score 1 presented the same prevalence in both methods; partial recording overestimated 0.2% of women classified as score 1; percentile difference among men was higher for subjects classified as score 0. Among subjects with at least one tooth with deep periodontal pocket, percentile difference between different approaches was higher among elders (60 years and over). Conclusions: Considering the variable age, the smaller amount of lost information refers to periodontal pockets in individuals aged 18 to 30 years of age. In older individuals classified as periodontally healthy and with gingival bleeding no loss of information was observed. Partial examination of the mouth underestimated the presence of periodontal pockets and overestimated the presence of calculus and bleeding. A high concordance between the partial and total examination was observed