3 research outputs found
Psychiatric consultations for nursing home residents: a perspective from Turkey and the implications for comparable countries
Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus
AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE)
Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus
AIM: To evaluate the possible neuroprotective effects of ketamine and
dantrolene on the hippocampal apoptosis and spatial learning in rats
exposed to repeated electroconvulsive seizures (ECS) as a model of
status epilepticus (SE).
MATERIAL and METHODS: Twenty-four rats were assigned to 4 groups. 1st
Group was Sham. 2nd Group was ECS: ECS was induced by ear electrodes via
electrical stimulation. The same ECS protocol was applied to the 3th and
4th Groups which received ketamine (40 mg/kg s.c.) or dantrolene (5
mg/kg i.p.) 1 h before each ECS, respectively. Following 30 days of
recovery, the cognitive status of the animals was evaluated via Morris
Water Maze (MWM). The same experimental protocol was repeated 14 days
afterward to evaluate the retention of the memory. Hippocampal apoptosis
was examined in corresponding experimental groups.
RESULTS: All the animals in four groups learned the task with no
significant difference between groups in MWM. The ECS+ketamine group
showed memory impairment 14 days afterward. ECS+dantrolene group was not
different from controls. ECS caused long term apoptotic processes in
dentate gyrus (DG) and non-apoptotic neuronal injury in CA1 and CA2.
CONCLUSION: Dantrolene and ketamine inhibited apoptosis and showed
neuroprotective effects. Although ketamine and dantrolene inhibited
ECS-induced apoptosis and non-apoptotic injury, they did not produce
similar effects on memory retention. It will be warranted to evaluate
cognitive dysfunction by taking into consideration the other factors in
addition to apoptosis and neurodegenerative changes