Correction of morphofunctional disturbances arising when modelling Preeclampsia with resveratrol and nicorandil

Preeclampsia is one of the most serious diseases of the second half of pregnancy and is surely amongst the top three causes of maternal mortality. Therefore, the creation of new drugs for preventing and correcting preeclampsia is an urgent tas

The effect of humoral factors released by hypoperfused placenta on fetal development

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologie

Study of the effect of selective inhibitor of arginase II KUD 975 and of low doses of acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsia

The article considers study of the effect of selective inhibitor of Arginase II KUD 975 and of low doses of acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsi

Evaluation of pharmacological correction of L-NAME-induced endothelial dysfunction, platelet aggregation and venous tone with diosmin detralex 1000 mg

Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For the correction of the occurring changes, drugs of the flavonoid group, particularly diosmin and hesperidin, are currently use

Mathematical model of liquid vapor compression system for multicircuit cooling systems of high mobile platform

© Research India Publications. The descriptions of the structure, the principle of operation and the mathematical model of the liquid-vapor compression cooling system, through which an effective cooling of a mobile platform power plant at elevated ambient temperature is possible. The proposed model allows to simulate the thermodynamic processes of heat and mass transfer and heat transfer, depending on the system load, its design parameters and the material of heat exchangers, the mass flow of refrigerant and coolant flow, taking into account the ambient temperature. The result of mathematical modeling showed that by the coolant temperature increase up to 127 °C, an average temperature pressure in a heat exchanger-condenser between the refrigerant and air increased. Therefore the amount of waste heat to the atmosphere was significantly increased. This will ensure an efficient operation of a cooling system at an elevated ambient temperature and will improve the weight and size of a cooling system in general

Simulation of total brain ischemia in rats

This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. The obtained results demonstrate a tendency to deterioration of neuropsychiatric status of the animals with increasing severity of ischemic brain damage that allows suggesting the severity of ischemic brain damage and its correction by the degree of behavioral disorder

Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010

Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsi

L-NAME-induced preeclampsia: correction of functional disorders of the hemostasis system with resveratrol and nicorandil

Preeclampsia is a formidable disease of the second half of pregnancy, leading to severe complications, including disability and even death. Many authors have recognized the correlation between the severity of preeclampsia and the degree of disturbances in the hemostasis system. In this regard, the objective of this study was to assess inhibition of platelet aggregation and the possibility of its correction with resverаtrol and nicorand

Influence of silver-ion-containing pharmacotherapeutic system for repair of anterior abdominal wall on connective tissue formation in experiment

In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for. The study undertaken was aimed at studying one of such systems consisting of a prosthesis coated with silver ions. The article notes that use of FCS contributes to the acceleration of reparative processes, earlier resolution of inflammation and stimulation of collagenesis both under sterile conditions and under microbial condition

The effect of arginase ii selective inhibitors on the functional parameters of experimental animals in ADMA–like preeclampsia

Perinatal mortality rate and the rate of preterm birth (10-12%) in pregnant women with hypertensive disorders far outweigh the corresponding values in women with physiological pregnancy. Despite such close attention worldwide to this problem, today the number of this complication has no tendency to decreas