1,898 research outputs found
Topological Dirac Semimetal Na3Bi Films in the Ultrathin Limit via Alternating Layer Molecular Beam Epitaxy
Ultrathin films of Na3Bi on insulating substrates are desired for opening a
bulk band gap and generating the quantum spin Hall effect from a topological
Dirac semimetal, though continuous films in the few nanometer regime have been
difficult to realize. Here, we utilize alternating layer molecular beam epitaxy
(MBE) to achieve uniform and continuous single crystal films of Na3Bi(0001) on
insulating Al2O3(0001) substrates and demonstrate electrical transport on films
with 3.8 nm thickness (4 unit cells). The high material quality is confirmed
through in situ reflection high-energy electron diffraction (RHEED), scanning
tunneling microscopy (STM), x-ray diffraction (XRD), and x-ray photoelectron
spectroscopy (XPS). In addition, these films are employed as seed layers for
subsequent growth by codeposition, leading to atomic layer-by-layer growth as
indicated by RHEED intensity oscillations. These material advances facilitate
the pursuit of quantum phenomena in thin films of Dirac semimetals.Comment: 11 pages, 5 figure
Observation of Skyrmion Bubbles in Multilayer [Pt/Co/Cu]n using spin-polarized STM
Magnetic multilayers are a promising platform for storage and logic devices
based on skyrmion spin textures, due to the large materials phase space for
tuning properties. Epitaxial superlattice structures of [Pt/Co/Cu]n thin films
were grown by molecular beam epitaxy at room temperature. Spin-polarized
scanning tunneling microscopy (SP-STM) of these samples was used to probe the
connection between surface structure and skyrmion morphology with nanoscale
spatial resolution. Irregular-shaped skyrmion bubbles were observed, with
effective diameters from 20-200 nm that are much larger than the nanoscale
grain structure of the surface topography. Nucleation, annihilation, and motion
of skyrmion bubbles could be driven using the stray field of the ferromagnetic
tip in repeated imaging, and spin-polarized current/voltage pulses. Our
detailed comparison of STM topography and differential conductance images shows
that there are no surface defects or inhomogeneities at length scales that
could account for the range in skyrmion bubble size or shape observed in the
measurements.Comment: 11 pages, 5 figure
Scanning tunneling microscopy studies of graphene and hydrogenated graphene on Cu
Because of the innate sensitivity of 2D material surfaces, it is increasingly important to understand and characterize surface functionalization and interactions with environmental elements, such as substrate, metallic contacts, and adatoms. We developed a method for reproducible, epitaxial growth of pristine graphene islands on Cu(111) in UHV and use scanning tunneling microscopy and spectroscopy (STM) to study the interaction of these graphene islands with the Cu substrate. Tunneling spectroscopy measurements of the electronic surface states over the graphene islands indicate a lower local work function, decreased coupling to bulk Cu states, and a decreased electron effective mass. Additionally, we developed a novel field electron dissociation technique to form hydrogen-terminated graphene at low temperatures and in UHV. This method produced what may be the first STM images of crystalline hydrogenated graphene. The pristine graphene island is then recovered by scanning at a high tip-sample bias. The hydrogenation and its reversibility suggest writing lateral 2D devices using the STM tip. Toward this end, we are developing the capability to repeat the hydrogenation on working graphene device
Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to specialized functions, including regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. However, the factors that influence mitochondrial biogenesis and function in neurons remain poorly elucidated. Here, we identify an important role for serotonin (5-HT) as a regulator of mitochondrial biogenesis and function in rodent cortical neurons, via a 5-HT2A receptor-mediated recruitment of the SIRT1–PGC-1α axis, which is relevant to the neuroprotective action of 5-HT. We found that 5-HT increased mitochondrial biogenesis, reflected through enhanced mtDNA levels, mitotracker staining, and expression of mitochondrial components. This resulted in higher mitochondrial respiratory capacity, oxidative phosphorylation (OXPHOS) efficiency, and a consequential increase in cellular ATP levels. Mechanistically, the effects of 5-HT were mediated via the 5-HT2A receptor and master modulators of mitochondrial biogenesis, SIRT1 and PGC-1α. SIRT1 was required to mediate the effects of 5-HT on mitochondrial biogenesis and function in cortical neurons. In vivo studies revealed that 5-HT2A receptor stimulation increased cortical mtDNA and ATP levels in a SIRT1-dependent manner. Direct infusion of 5-HT into the neocortex and chemogenetic activation of 5-HT neurons also resulted in enhanced mitochondrial biogenesis and function in vivo. In cortical neurons, 5-HT enhanced expression of antioxidant enzymes, decreased cellular reactive oxygen species, and exhibited neuroprotection against excitotoxic and oxidative stress, an effect that required SIRT1. These findings identify 5-HT as an upstream regulator of mitochondrial biogenesis and function in cortical neurons and implicate the mitochondrial effects of 5-HT in its neuroprotective action.Fil: Fanibunda, S. E.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; España. Kasturba Health Society; IndiaFil: Deb, Sukrita. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Maniyadath, Babukrishna. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Tiwari, Praachi. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Ghai, Utkarsha. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Gupta, Samir. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Figueiredo, Dwight. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Weisstaub, Noelia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Gingrich, Jay A.. Columbia University; Estados UnidosFil: Vaidya, Ashok D.B.. Kasturba Health Society; IndiaFil: Kolthur Seetharam, Ullas. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: Vaidya, Vidita A.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; Españ
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