History & Impression of Hacking on the Society

The hackers have been widespread throughout the IT world. The main categories of Hackers have evolved: the Open Source and Free Software group and the Security Hackers group these both groups are function differently and there concept and method are differ from each other . In this paper we are discussed on some of the more noteworthy groups and individuals of each 'category' of hackers, the effects of hacking on society, as well as conferences and publications that they are responsible for that have contributed to the modern hacking world. Hacking is just like a cancer that has very dangerous effects on the society. Today in this modern world, where measures have been taken to improve the security level in the distributed systems ,hackers have found a way to crack into systems and take away information. In this paper, we will explain you few aspects of hacking, tools and technique used by hackers that has caused of its existence and few techniques through which we can minimize this

Critical analysis of Raktavaha Srotas

Srotas (body channels) is considered as an important entity of the body and is responsible for the Vahana (transferring) of Dosha, Dhatu etc. Full body is considered as Srotomaya (made of Srotas). These Srotas are very closely associated with their respective moolasthana. These Moolsthana are very important from treatment and prognostic aspect as its involvement in the formation, examination and control over the Bhavapadartha flowing through the Srotasa. The Rakta dhatu (blood) which is also referred as fourth Dosha by Ayurveda, is one of the important functional element of body of which formation, transformation and conduction is carried out by Raktavaha Srotas. The root of Raktavaha Srotas is considered as Yakrut (Liver) and Pleeha (Spleen). Injury to Raktavaha Srotas leads to Cyanoses, Fever, Anemia, hemorrhage, reddish discoloration of eyes. Raktavaha Srotas gets vitiated by consumption of spicy food and drinks, Unctous & hot food stuffs and beverages, excessive consumption of liquids, excessive exposure to sunlight & wind. The characteristic manifestation of the vitiation of Raktavaha Srotas leads to different types of Skin disorders, abscess formation, Jaundice

MONITOR THE USE OF ANTIBIOTICS IN INTENSIVE CARE UNITS WITH SPECIAL FOCUS ON RESTRICTED ANTIBIOTICS IN TERTIARY CARE HOSPITAL OF INDIA

Objective: The present study was to monitor the use of antibiotics with restricted antibiotics in intensive care units (ICUs). The aim of this studywas to observe number of patients receiving antibiotic(s), to observe number of patient receiving restricted antibiotics(s), number of restrictedantibiotic(s) forms filled in 48 hrs, observing number of instances where within three or more than three antibiotics given for more than 3 days, anyadverse drug reaction and medication error related in ICUs.Methods: The study was done prospectively in ICUs of a tertiary care hospital. 200 patients were selected from ICUs on a random basis. The durationstudy was 6.5 months. All adult patients admitted in ICUs who received an antibiotic therapy within 24 hrs of admission were included. Outpatientdepartment patients and patient admitted in the wards were not included in the study.Results: Among 200 patients, the total number of patients received antibiotic were 188 (94%), while 12 (6%) patients were not received. Among188 patients, 51 patients received restricted antibiotics, i.e., 27.2% and 137 patients not received restricted antibiotic, i.e. 72.8%. Out of 188 patientsreceived antibiotics including restricted antibiotics only 31 patients received three or more than three antibiotics for three or more than three days,which are 16.4% and 157 patients, not received three or more than three antibiotics for three or more than three days which were 83.6%. Accordingto Antimicrobial Stewardship Program, physician prescribed restricted antibiotic must have to fill restricted antimicrobial form, among 51 patients,only 8 (15.6%) forms were received.Keywords: Antibiotics, Restricted antibiotics, Outpatient department, Antimicrobial stewardship program, Intensive care units

Anti-inflammatory potential of ginseng for wound healing

© 2022 The Authors. Published by IntechOpen. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://www.intechopen.com/chapters/79331The recovery of skin wounds is a complex biological process involving three basic mechanisms: inflammatory phase, re-epithelialization followed by granulation and tissue remodeling. The interactions between inflammatory cells, fibroblasts, and keratinocytes induce microenvironmental changes at the wound site. Tissue remodeling is initiated by matrix-producing proteins and protease enzymes and collagen fibers in the dermis. A saponin extracted from ginseng, known as ginsenoside, has been shown to accelerate neovascularization in burn wounds in mice. It also increases levels of vascular endothelial growth factor and interleukin (IL-β). IL-β accelerate wound healing by promoting accumulation of macrophages at skin wound sites. Saponins are major active constituents of ginseng. They contain many ginsenosides. The purified ginsenosides or the extracts of ginseng root have been reported to have beneficial effects on damaged skin. For instance, red ginseng root extract protected skin from acute UVB-irradiation. Ginsenoside F1, an enzymatically modified derivative of the ginsenoside Rg1, protected HaCaT against UVB-induced apoptosis. Panax ginseng root extract promotes type I collagen synthesis in human dermal fibroblasts (HDF) via the Smad activation pathway and exhibits antioxidant activity against free radicles including diphenyl-p-picrylhydrazyl treatment. In addition, ginsenoside Rb1 promotes healing process of burn wound by enhancing angiogenesis. Among the various ginsenosides, ginsenoside Rb1 has been found to most potent agent for wound healing.Published onlin

Characterisation and In Vitro Antimicrobial Activity of Biosynthetic Silver-loaded Bacterial Cellulose Hydrogels

Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications

Epidemiology of Clostridium difficile in infants in Oxfordshire, UK: Risk factors for colonization and carriage, and genetic overlap with regional C. difficile infection strains

Background: Approximately 30-40% of children <1 year of age are Clostridium difficile colonized, and may represent a reservoir for adult C. difficile infections (CDI). Risk factors for colonization with toxigenic versus non-toxigenic C. difficile strains and longitudinal acquisition dynamics in infants remain incompletely characterized. Methods: Predominantly healthy infants (≤2 years) were recruited in Oxfordshire, UK, and provided ≥1 fecal samples. Independent risk factors for toxigenic/non-toxigenic C. difficile colonization and acquisition were identified using multivariable regression. Infant C. difficile isolates were whole-genome sequenced to assay genetic diversity and prevalence of toxin-associated genes, and compared with sequenced strains from Oxfordshire CDI cases. Results: 338/365 enrolled infants provided 1332 fecal samples, representing 158 C. difficile colonization or carriage episodes (107[68%] toxigenic). Initial colonization was associated with age, and reduced with breastfeeding but increased with pet dogs. Acquisition was associated with older age, Caesarean delivery, and diarrhea. Breastfeeding and pre-existing C. difficile colonization reduced acquisition risk. Overall 13% of CDI C. difficile strains were genetically related to infant strains. 29(18%) infant C. difficile sequences were consistent with recent direct/indirect transmission to/from Oxfordshire CDI cases (≤2 single nucleotide variants [SNVs]); 79(50%) shared a common origin with an Oxfordshire CDI case within the last ~5 years (0-10 SNVs). The hypervirulent, epidemic ST1/ribotype 027 remained notably absent in infants in this large study, as did other lineages such as STs 10/44 (ribotype 015); the most common strain in infants was ST2 (ribotype 020/014)(22%). Conclusions: In predominantly healthy infants without significant healthcare exposure C. difficile colonization and acquisition reflect environmental exposures, with pet dogs identified as a novel risk factor. Genetic overlap between some infant strains and those isolated from CDI cases suggest common community reservoirs of these C. difficile lineages, contrasting with those lineages found only in CDI cases, and therefore more consistent with healthcare-associated spread