Structure and function of pancreatic lipase-related protein 2 and its relationship with pathological states

Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PTL or PNLIP) and its family members, pancreatic lipase-related protein 1 (PNLIPRP1or PLRP1) and pancreatic lipase-related protein 2 (PNLIPRP2 or PLRP2). Unlike the family\u27s other members, PNLIPRP2 plays an elemental role in lipid digestion, especially for newborns. Therefore, if genetic factors cause gene mutation, or other factors lead to non-expression, it may have an effect on fat digestion and absorption, on the susceptibility to pancreas and intestinal pathogens. In this review, we will summarize what is known about the structure and function of PNLIPRP2 and the levels of PNLIPRP2 and associated various pathological states

Optimization of Process Parameters of Stamping Forming of the Automotive Lower Floor Board

There are many process parameters which have great effect on the forming quality of parts during automobile panel stamping forming process. This paper took automotive lower floor board as the research object; the forming process was analyzed by finite element simulation using Dynaform. The influences of four main process parameters including BHF (blank holder force), die corner radius, friction coefficient, and die clearance on the maximum thinning rate and the maximum thickening rate were researched based on orthogonal experiment. The results show that the influences of each value of various factors on the target are not identical. On this basis, the optimization of the four parameters was carried out, and the high quality product was obtained and the maximum thinning rate and maximum thickening rate were effectively controlled. The results also show that the simulation analysis provides the basis for the optimization of the forming process parameters, and it can greatly shorten the die manufacturing cycles, reduce the production costs, and improve the production efficiency

The 9th Shanghai International Library Forum (SILF 2018)

The 9th Shanghai International Library Forum (SILF 2018

The expression profile analysis of NKX2-5 knock-out embryonic mice to explore the pathogenesis of congenital heart disease

AbstractBackgroundMutation of NKX2-5 could lead to the development of congenital heart disease (CHD) which is a common inherited disease. This study aimed to investigate the pathogenesis of CHD in NKX2-5 knock-out embryonic mice.MethodsThe expression profile in the NKX2-5 knock-out embryonic mice (GSE528) was downloaded from Gene Expression Omnibus. The heart tissues from the null/heterozygous embryonic day 12.5 mice were compared with wild-type mice to identify differentially expressed genes (DEGs), and then DEGs corresponding to the transcriptional factors were filtered out based on the information in the TRANSFAC database. In addition, a transcriptional regulatory network was constructed according to transcription factor binding site information from the University of California Santa Cruz database. A pathway interaction network was constructed by latent pathways identification analysis.ResultsThe 42 DEGs corresponding to transcriptional factors from the null and heterozygous embryos were identified. The transcriptional regulatory networks included five down-regulated DEGs (SP1, SRY, JUND, STAT6, and GATA6), and six up-regulated DEGs [POU2F1, NFY (NFYA/NFYB/NFYC), USF2 and MAX]. Latent pathways analysis demonstrated that ribosome, glycolysis/gluconeogenesis, and dilated cardiomyopathy pathways significantly interacted.ConclusionThe identified DEGs and latent pathways could provide new comprehensive view for understanding the pathogenesis of CHD

Emission of PAHs, NPAHs and OPAHs from residential honeycomb coal briquette combustion

Coal combustion is one of the most significant sources of air pollution in China. In this study, emission factors (EFs) of 15 polycyclic aromatic hydrocarbons (PAHs), 26 nitrated PAHs (NPAHs) and 6 oxygenated PAHs (OPAHs) were determined in five different coals with different geological maturity (vitrinite reflectance <i>R</i>_O = 0.77–1.88%) burned in the form of honeycomb briquettes. The total EFs ranged from 9.82 to 215 mg kg^–1 for PAHs, 0.14 to 1.88 mg kg^–1 for NPAHs and 4.47 to 20.8 mg kg^–1 for OPAHs. Measured EFs and gas-particle partitioning varied depending on the geological maturity. The lowest EFs were found in anthracite. The proportion of PAHs, NPAHs and OPAHs in gaseous phase increasing with increased geological maturity. The coal with higher geological maturity produced more 3-ring PAHs. On the basis of the statistical analysis for the residential sector of China in 2008, PAHs, NPAHs and OPAHs emitted from residential honeycomb coal briquettes were 4.36 Gg, 0.03 Gg and 0.47 Gg in 2007, respectively. By 2020, the emission would decrease to 2.18 Gg, 0.02 Gg and 0.24 Gg for PAHs, NPAHs and OPAHs due to the increasing usage of new energy resources. If only anthracite is used as the residential coal, 93% PAHs, 87% NPAHs and 71% OPAHs would be reduced in 2020

Analysis of corrections to the eikonal approximation

Various corrections to the eikonal approximations are studied for two- and three-body nuclear collisions with the goal to extend the range of validity of this approximation to beam energies of 10 MeV/nucleon. Wallace's correction does not improve much the elastic-scattering cross sections obtained at the usual eikonal approximation. On the contrary, a semiclassical approximation that substitutes the impact parameter by a complex distance of closest approach computed with the projectile-target optical potential efficiently corrects the eikonal approximation. This opens the possibility to analyze data measured down to 10 MeV/nucleon within eikonal-like reaction models.Comment: 10 pages, 8 figure

Study on Roadheader Cutting Load at Different Properties of Coal and Rock

The mechanism of cutting process of roadheader with cutting head was researched, and the influences of properties of coal and rock on cutting load were deeply analyzed. Aimed at the defects of traditional calculation method of cutting load on fully expressing the complex cutting process of cutting head, the method of finite element simulation was proposed to simulate the dynamic cutting process. Aimed at the characteristics of coal and rock which affect the cutting load, several simulations with different firmness coefficient were taken repeatedly, and the relationship between three-axis force and firmness coefficient was derived. A comparative analysis of cutting pick load between simulation results and theoretical formula was carried out, and a consistency was achieved. Then cutting process with a total cutting head was carried out on this basis. The results show that the simulation analysis not only provides a reliable guarantee for the accurate calculation of the cutting head load and improves the efficiency of the cutting head cutting test but also offers a basis for selection of cutting head with different geological conditions of coal or rock