Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi.

Recent increases in the prevalence and severity of wildfires in some regions have resulted in an increased frequency of veterinary burn patients. Few studies exist regarding diagnostics and management of burn wounds in veterinary patients and current knowledge is extrapolated from human literature and research models. Post-burn cardiac injury is a common finding and predictor of mortality in human patients and echocardiography is an important tool in monitoring response to therapy and predicting outcome. We describe the notable findings from cats naturally exposed to California wildfires in 2017 and 2018. Domestic cats (n = 51) sustaining burn injuries from the Tubbs (2017) and Camp (2018) wildfires were prospectively enrolled and serial echocardiograms and cardiac troponin I evaluations were performed. Echocardiograms of affected cats revealed a high prevalence of myocardial thickening (18/51) and spontaneous echocardiographic contrast and thrombi formation (16/51). Forty-two cats survived to discharge and 6 died or were euthanized due to a possible cardiac cause. For the first time, we describe cardiovascular and coagulation effects of thermal burn and smoke inhalation in cats. Further studies in veterinary burn victims are warranted and serve as a translational research opportunity for uncovering novel disease mechanisms and therapies

Echocardiographic evaluation of velocity ratio, velocity time integral ratio, and pulmonary valve area in dogs with pulmonary valve stenosis.

BackgroundVelocity ratio, velocity time integral (VTI) ratio, and pulmonary valve area indexed to body surface area (iPVA) are methods of assessment of pulmonary valve stenosis (PS) severity that are less dependent on blood flow. Studies evaluating these methods are limited.ObjectivesTo determine the effects of butorphanol, atenolol, and balloon valvuloplasty (BV) on velocity ratio, VTI ratio, iPVA, mean PG, and max PG.AnimalsTwenty-seven dogs with PS (max PG >50 mm Hg).MethodsProspective study. All dogs underwent an echocardiogram at baseline, 5-minutes after administration of butorphanol (0.2-0.25 mg/kg IV), and 2-to-4 weeks after atenolol (1-1.5 mg/kg q12h). Twenty-one of these were evaluated 24-hours after BV.ResultsThere were no significant differences (P > .05) amongst any of the methods of assessment of PS severity after butorphanol. After atenolol, mean (SD) of mean (57.0 [21.0] mm Hg) and max PG (93.1 [33.8] mm Hg) were significantly decreased (P ≤ .047) compared with baseline (65.2 [26.2] mm Hg and 108 [44.4] mm Hg, respectively). After atenolol, there were no significant (P ≥ .12) differences in velocity ratio (0.29 [0.09]), VTI ratio (0.18 [0.05]), or iPVA (0.43 [0.16] cm2 /m2 ) compared with baseline (0.30 [0.09], 0.19 [0.09], 0.44 [0.17] cm2 /m2 , respectively).Conclusions and clinical importanceAtenolol might reduce mean and max PG but does not alter less flow-dependent methods of assessment of PS severity (velocity ratio, VTI ratio, and iPVA) in dogs with PS. Results support an integrative approach to assessment of PS severity that includes less flow-dependent methods, particularly in states of altered flow or right ventricular function

Quantale-valued Cauchy tower spaces and completeness

[EN] Generalizing the concept of a probabilistic Cauchy space, we introduce quantale-valued Cauchy tower spaces. These spaces encompass quantale-valued metric spaces, quantale-valued uniform (convergence) tower spaces and quantale-valued convergence tower groups. For special choices of the quantale, classical and probabilistic metric spaces are covered and probabilistic and approach Cauchy spaces arise. We also study completeness and completion in this setting and establish a connection to the Cauchy completeness of a quantale-valued metric space.Jäger, G.; Ahsanullah, TMG. (2021). Quantale-valued Cauchy tower spaces and completeness. Applied General Topology. 22(2):461-481. https://doi.org/10.4995/agt.2021.15610OJS461481222J. Adámek, H. Herrlich and G. E. Strecker, Abstract and Concrete Categories, Wiley, New York, 1989.T. M. G. Ahsanullah and G. Jäger, Probabilistic uniform convergence spaces redefined, Acta Math. 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Electromagnetic wormholes and virtual magnetic monopoles

We describe new configurations of electromagnetic (EM) material parameters, the electric permittivity $\epsilon$ and magnetic permeability $\mu$, that allow one to construct from metamaterials objects that function as invisible tunnels. These allow EM wave propagation between two points, but the tunnels and the regions they enclose are not detectable to EM observations. Such devices function as wormholes with respect to Maxwell's equations and effectively change the topology of space vis-a-vis EM wave propagation. We suggest several applications, including devices behaving as virtual magnetic monopoles.Comment: 4 pages, 3 figure