107 research outputs found
Effects of Concurrent Selection for Residual Feed Intake and Average Daily Gain on Fertility and Longevity in Black Angus Beef Females
Data from this analysis suggest that concurrent selection for both average daily gain and residual feed intake (RFI) may identify beef heifers that have improved fertility and longevity without impacting growth and maternal EPDs. As the beef industry continues to focus on sustainability, and thus efficiency, identification of commercial breeding stock that fit this mold will be imperative
Understanding the Astrophysics of Galaxy Evolution: the role of spectroscopic surveys in the next decade
Over the last decade optical spectroscopic surveys have characterized the low
redshift galaxy population and uncovered populations of star-forming galaxies
back to z ~ 7. This work has shown that the primary epoch of galaxy building
and black hole growth occurs at redshifts of 2 to 3. The establishment of the
concordance LCDM cosmology shifted the focus of galaxy population studies from
constraining cosmological parameters to characterizing the processes which
regulate the formation and evolution of galaxies.In the next decade, high
redshift observers will attempt to formulate a coherent evolutionary picture
connecting galaxies in the high redshift Universe to galaxies today. In order
to link galaxy populations at different redshifts, we must not only
characterize their evolution in a systematic way, we must establish which
physical processes are responsible for it. Considerable progress has already
been made in understanding how galaxies evolved from z ~ 1 to the present day.
Large spectroscopic surveys in the near infrared are required to push these
studies back towards the main epoch of galaxy building. Only then will we
understand the full story of the formation of L* galaxies like our own Milky
Way. A large near-IR spectroscopic survey will also provide the calibration
needed to avoid systematics in the large photometric programs proposed to study
the nature of dark matter and dark energy. We provide an outline design for a
multi-object 0.4 to 1.8 micron spectrograph, which could be placed on an
existing telescope, and which would allow a full characterization of the galaxy
population out to z ~ 2. We strongly recommend a serious further study to
design a real instrument, which will be required for galaxy formation studies
to advance to the next frontier.Comment: White paper, primary author J.E. Gunn, submitted to Astro2010 Decadal
Survey, see http://www7.nationalacademies.org/bpa/Astro2010_SWP_byTitle.htm
The Sloan Digital Sky Survey Quasar Catalog V. Seventh Data Release
We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar
Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which
contains 105,783 spectroscopically confirmed quasars, represents the conclusion
of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS
objects that have luminosities larger than M_i = -22.0 (in a cosmology with H_0
= 70 km/s/Mpc Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission
line with FWHM larger than 1000 km/s or have interesting/complex absorption
features, are fainter than i > 15.0 and have highly reliable redshifts. The
catalog covers an area of 9380 deg^2. The quasar redshifts range from 0.065 to
5.46, with a median value of 1.49; the catalog includes 1248 quasars at
redshifts greater than four, of which 56 are at redshifts greater than five.
The catalog contains 9210 quasars with i < 18; slightly over half of the
entries have i< 19. For each object the catalog presents positions accurate to
better than 0.1" rms per coordinate, five-band (ugriz) CCD-based photometry
with typical accuracy of 0.03 mag, and information on the morphology and
selection method. The catalog also contains radio, near-infrared, and X-ray
emission properties of the quasars, when available, from other large-area
surveys. The calibrated digital spectra cover the wavelength region 3800-9200
Ang. at a spectral resolution R = 2000 the spectra can be retrieved from the
SDSS public database using the information provided in the catalog. Over 96% of
the objects in the catalog were discovered by the SDSS. We also include a
supplemental list of an additional 207 quasars with SDSS spectra whose archive
photometric information is incomplete.Comment: Accepted, to appear in AJ, 7 figures, electronic version of Table 2
is available, see
http://www.sdss.org/dr7/products/value_added/qsocat_dr7.htm
Challenging the negative images of Haiti at a pre-visit stage using visual online learning materials
Post-conflict destinations can struggle to attract visitors because of their negative image. Research addressing this remains limited. The same can be said about the education of tourists. This research paper contributes to the literature in both areas as it examines the proposition that the education of tourists at a pre-visit stage using online, game-based material could be effective in challenging the negative perception of these destinations. From a destination management point of view, this paper offers an alternative to existing promotional material as there is little evidence at the moment that existing strategies are effective. From a conceptual point of view, this paper contributes to the very limited academic research in Gamification by adding the fact that Gamification can be a very efficient tryvertising tool if using subtle and implicit marketing elements
The Sloan Digital Sky Survey Quasar Catalog IV. Fifth Data Release
We present the fourth edition of the Sloan Digital Sky Survey (SDSS) Quasar
Catalog. The catalog contains 77,429 objects; this is an increase of over
30,000 entries since the previous edition. The catalog consists of the objects
in the SDSS Fifth Data Release that have luminosities larger than M_i = -22.0
(in a cosmology with H_0 = 70 km/s/Mpc, Omega_M = 0.3, and Omega_Lambda = 0.7)
have at least one emission line with FWHM larger than 1000 km/s, or have
interesting/complex absorption features, are fainter than i=15.0, and have
highly reliable redshifts. The area covered by the catalog is 5740 sq. deg. The
quasar redshifts range from 0.08 to 5.41, with a median value of 1.48; the
catalog includes 891 quasars at redshifts greater than four, of which 36 are at
redshifts greater than five. Approximately half of the catalog quasars have i <
19; nearly all have i < 21. For each object the catalog presents positions
accurate to better than 0.2 arcsec. rms per coordinate, five-band (ugriz)
CCD-based photometry with typical accuracy of 0.03 mag, and information on the
morphology and selection method. The catalog also contains basic radio,
near-infrared, and X-ray emission properties of the quasars, when available,
from other large-area surveys. The calibrated digital spectra cover the
wavelength region 3800--9200A at a spectral resolution of ~2000. The spectra
can be retrieved from the public database using the information provided in the
catalog. The average SDSS colors of quasars as a function of redshift, derived
from the catalog entries, are presented in tabular form. Approximately 96% of
the objects in the catalog were discovered by the SDSS.Comment: 37 pages, Accepted for publication in A
Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired patients and 9 age-matched healthy controls) underwent brain scanning using the novel reactive astrocyte PET tracer (11)C-BU99008, (18)F-FDG and (18)F-florbetaben PET, and T1-weighted MRI. Differences between cognitively impaired patients and healthy controls in regional and voxel-wise levels of astrocyte reactivity, glucose metabolism, grey matter volume and amyloid load were explored, and their relationship to each other was assessed using Biological Parametric Mapping (BPM). Amyloid beta (Aβ)-positive patients showed greater (11)C-BU99008 uptake compared to controls, except in the temporal lobe, whilst further increased (11)C-BU99008 uptake was observed in Mild Cognitive Impairment subjects compared to those with Alzheimer’s disease in the frontal, temporal and cingulate cortices. BPM correlations revealed that regions which showed reduced (11)C-BU99008 uptake in Aβ-positive patients compared to controls, such as the temporal lobe, also showed reduced (18)F-FDG uptake and grey matter volume, although the correlations with (18)F-FDG uptake were not replicated in the ROI analysis. BPM analysis also revealed a regionally-dynamic relationship between astrocyte reactivity and amyloid uptake: increased amyloid load in cortical association areas of the temporal lobe and cingulate cortices was associated with reduced (11)C-BU99008 uptake, whilst increased amyloid uptake in primary motor and sensory areas (in which amyloid deposition occurs later) was associated with increased (11)C-BU99008 uptake. These novel observations add to the hypothesis that while astrocyte reactivity may be triggered by early Aβ-deposition, sustained pro-inflammatory astrocyte reactivity with greater amyloid deposition may lead to astrocyte dystrophy and amyloid-associated neuropathology such as grey matter atrophy and glucose hypometabolism, although the evidence for glucose hypometabolism here is less strong
Aptamer-based multiplexed proteomic technology for biomarker discovery
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine
- …