The effects of anaesthesia on cell death in a porcine model of neonatal hypoxic-ischaemic brain injury

Background: Hypothermia is neuroprotective after neonatal hypoxic-ischaemic brain injury. However, systemic cooling to hypothermic temperatures is a stressor and may reduce neuroprotection in awake pigs. We compared two experiments of global hypoxic-ischaemic injury in newborn pigs, in which one group received propofol–remifentanil and the other remained awake during post-insult hypothermia treatment. Methods: In both studies, newborn pigs were anaesthetised using halothane during a 45-min global hypoxic-ischaemic insult induced by reducing Fio2 and graded hypotension until a low-voltage <7 μV electroencephalogram was achieved. On reoxygenation, the pigs were randomly allocated to receive 24 h of normothermia or hypothermia. In the first study (n=18) anaesthesia was discontinued and the pigs' tracheas were extubated. In the second study (n=14) anaesthesia was continued using propofol and remifentanil. Brain injury was assessed after 72 h by classical global histopathology, Purkinje cell count, and apoptotic cell counts in the hippocampus and cerebellum. Results: Global injury was nearly 10-fold greater in the awake group compared with the anaesthetised group (P=0.021). Hypothermia was neuroprotective in the anaesthetised pigs but not the awake pigs. In the hippocampus, the density of cleaved caspase-3-positive cells was increased in awake compared with anaesthetised pigs in normothermia. In the cerebellum, Purkinje cell density was reduced in the awake pigs irrespective of treatment, and the number of cleaved caspase-3-positive Purkinje cells was greatly increased in hypothermic awake pigs. We detected no difference in cleaved caspase-3 in the granular cell layer or microglial reactivity across the groups. Conclusions: Our study provides novel insights into the significance of anaesthesia/sedation during hypothermia for achieving optimal neuroprotection

Breaking the Redshift Deadlock - I: Constraining the star formation history of galaxies with sub-millimetre photometric redshifts

Future extragalactic sub-millimetre and millimetre surveys have the potential to provide a sensitive census of the level of obscured star formation in galaxies at all redshifts. While in general there is good agreement between the source counts from existing SCUBA (850um) and MAMBO (1.25mm) surveys of different depths and areas, it remains difficult to determine the redshift distribution and bolometric luminosities of the sub-millimetre and millimetre galaxy population. This is principally due to the ambiguity in identifying an individual sub-millimetre source with its optical, IR or radio counterpart which, in turn, prevents a confident measurement of the spectroscopic redshift. Additionally, the lack of data measuring the rest-frame FIR spectral peak of the sub-millimetre galaxies gives rise to poor constraints on their rest-frame FIR luminosities and star formation rates. In this paper we describe Monte-Carlo simulations of ground-based, balloon-borne and satellite sub-millimetre surveys that demonstrate how the rest-frame FIR-sub-millimetre spectral energy distributions (250-850um) can be used to derive photometric redshifts with an r.m.s accuracy of +/- 0.4 over the range 0 < z < 6. This opportunity to break the redshift deadlock will provide an estimate of the global star formation history for luminous optically-obscured galaxies [L(FIR) > 3 x 10^12 Lsun] with an accuracy of 20 per cent.Comment: 14 pages, 22 figures, submitted to MNRAS, replaced with accepted versio

CFS/ME OG AKTIVITETSAVPASNING En litteraturstudie om mennesker med CFS/ME sine opplevelser av aktivitetsavpasning (pacing)

Problemstilling: “Hvordan oppleves aktivitetsavpasning (Pacing) som en mestringsstrategi for personer med mild-moderat CFS/ME?”. Formål: Formålet med denne oppgaven er å undersøke hva forskning sier om pasienter med Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) sine opplevelser knyttet til aktivitetsavpasning. Metode: Foretatt systematisk litteratursøk for å finne kvalitative studier som viser hvilke opplevelser mennesker med CFS/ME har til aktivitetsavpasning. De vitenskapelige artiklene som blir brukt i litteraturgjennomgangen er presentert i ulike databaser: EBSCO (Academic search elite), Pubmed og EMBASE. Aveyards tematiske analysemodell beskrevet i Thidemann ble benyttet for å analysere resultatene. Resultat: Aktivitetsavpasning ble i stor grad ansett som positivt, hvor denne mestringsstrategien ble brukt for å forhindre forverring av symptomer. Det gav et endret aktivitetsmønster, bevissthet på gjennomførelse av aktiviteter, energinivå og å få en positiv tankegang, samt motivasjon. Samtidig finnes det også utfordringer for å kunne ta i bruk aktivitetsavpasning som, symptomer, manglende kontroll, følelser og personlige egenskaper. Konklusjon: Gjennom utførelsen av denne litteraturstudien kommer det frem at mennesker med CFS/ME opplever aktivitetsavpasning som en nyttig mestringsstrategi. Det er videre behov for nyere og større studier som omhandler erfaringer, men også studier som viser effekt. Det er nødvendig for å kunne gi anbefalinger i videre praksis.publishedVersio

An Exploratory Study Of Student Satisfaction With University Web Page Design

This exploratory study evaluates the satisfaction of students with a web-based information system at a medium-sized regional university. The analysis provides a process for simplifying data interpretation in captured student user feedback. Findings indicate that student classifications, as measured by demographic and other factors, determine satisfaction levels towards various web sources of information. Differences in satisfaction levels across student groups based on gender, age, minority status, employment, and current course load were found. Implications for university web designers and university administrators are considered and discussed

Measurements of Anisotropy in the Cosmic Microwave Background Radiation at 0.5 Degree Angular Scales Near the Star Gamma Ursae Minoris

We present results from a four frequency observation of a 6 x 0.6 degree strip of the sky centered near the star Gamma Ursae Minoris during the fourth flight of the Millimeter-wave Anisotropy eXperiment (MAX). The observation was made with a 1.4 degree peak-to-peak sinusoidal chop in all bands. The FWHM beam sizes were 0.55 +/- 0.05 degrees at 3.5 cm-1 and 0.75 +/-0.05 degrees at 6, 9, and 14 cm-1. During this observation significant correlated structure was observed at 3.5, 6 and 9 cm-1 with amplitudes similar to those observed in the GUM region during the second and third flights of MAX. The frequency spectrum is consistent with CMB and inconsistent with thermal emission from interstellar dust. The extrapolated amplitudes of synchrotron and free-free emission are too small to account for the amplitude of the observed structure. If all of the structure is attributed to CMB anisotropy with a Gaussian autocorrelation function and a coherence angle of 25', then the most probable values of DeltaT/TCMB in the 3.5, 6, and 9 cm-1 bands are 4.3 (+2.7, -1.6) x 10-5, 2.8 (+4.3, -1.1) x 10-5, and 3.5 (+3.0, -1.6) x 10-5 (95% confidence upper and lower limits), respectively.Comment: 16 pages, postscrip

Measurements of Anisotropy in the Cosmic Microwave Background Radiation at Degree Angular Scales Near the Stars Sigma Hercules and Iota Draconis

We present results from two four-frequency observations centered near the stars Sigma Hercules and Iota Draconis during the fourth flight of the Millimeter-wave Anisotropy eXperiment (MAX). The observations were made of 6 x 0.6-degree strips of the sky with 1.4-degree peak to peak sinusoidal chop in all bands. The FWHM beam sizes were 0.55+/-0.05 degrees at 3.5 cm-1 and a 0.75+/-0.05 degrees at 6, 9, and 14 cm-1. Significant correlated structures were observed at 3.5, 6 and 9 cm-1. The spectra of these signals are inconsistent with thermal emission from known interstellar dust populations. The extrapolated amplitudes of synchrotron and free-free emission are too small to account for the amplitude of the observed structures. If the observed structures are attributed to CMB anisotropy with a Gaussian autocorrelation function and a coherence angle of 25', then the most probable values are DT/TCMB = (3.1 +1.7-1.3) x 10^-5 for the Sigma Hercules scan, and DT/TCMB = (3.3 +/- 1.1) x 10^-5 for the Iota Draconis scan (95% confidence upper and lower limits). Finally a comparison of all six MAX scans is presented.Comment: 13 pages, postscript file, 2 figure

SANEPIC: A Map-Making Method for Timestream Data From Large Arrays

We describe a map-making method which we have developed for the Balloon-borne Large Aperture Submillimeter Telescope (BLAST) experiment, but which should have general application to data from other submillimeter arrays. Our method uses a Maximum Likelihood based approach, with several approximations, which allows images to be constructed using large amounts of data with fairly modest computer memory and processing requirements. This new approach, Signal And Noise Estimation Procedure Including Correlations (SANEPIC), builds upon several previous methods, but focuses specifically on the regime where there is a large number of detectors sampling the same map of the sky, and explicitly allowing for the the possibility of strong correlations between the detector timestreams. We provide real and simulated examples of how well this method performs compared with more simplistic map-makers based on filtering. We discuss two separate implementations of SANEPIC: a brute-force approach, in which the inverse pixel-pixel covariance matrix is computed; and an iterative approach, which is much more efficient for large maps. SANEPIC has been successfully used to produce maps using data from the 2005 BLAST flight.Comment: 27 Pages, 15 figures; Submitted to the Astrophysical Journal; related results available at http://blastexperiment.info/ [the BLAST Webpage