115 research outputs found
Biomimetic Modeling of Copper Complexes: A Study of Enantioselective Catalytic Oxidation on D-(+)-Catechin and L-( â )-Epicatechin with Copper Complexes
The biomimetic catalytic oxidations of the dinuclear and trinuclear copper(II) complexes versus two catechols, namely, D-(+)-catechin
and L-( â )-epicatechin to give the corresponding quinones are reported. The unstable quinones were trapped by the nucleophilic reagent, 3-methyl-2-benzothiazolinone hydrazone (MBTH), and have been calculated the molar
absorptivities of the different quinones. The catalytic efficiency is moderate, as inferred by kinetic constants, but the complexes exhibit significant enantio-differentiating ability towards the catechols, albeit for the dinuclear complexes, this enantio-differentiating ability is lower. In all cases, the preferred enantiomeric substrate is D-(+)-catechin to respect the other catechol, because of the spatial disposition of this substrate
Azide-binding studies reveal type 3 copper heterogeneity in ascorbate oxidase from the green zucchini squash (Cucurbita pepo)
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo
Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work, we synthesize and characterize polymeric gene delivery nanoparticles and evaluate their efficacy for DNA delivery of herpes simplex virus type I thymidine kinase (HSVtk) combined with the prodrug ganciclovir (GCV) in a malignant glioma model. We investigated polymer structure for gene delivery in two rat glioma cell lines, 9L and F98, to discover nanoparticle formulations more effective than the leading commercial reagent Lipofectamine 2000. The lead polymer structure, poly(1,4-butanediol diacrylate-co-4-amino-1-butanol) end-modified with 1-(3-aminopropyl)-4-methylpiperazine, is a poly(\u3b2-amino ester) (PBAE) and formed nanoparticles with HSVtk DNA that were 138 \ub1 4 nm in size and 13 \ub1 1 mV in zeta potential. These nanoparticles containing HSVtk DNA showed 100% cancer cell killing in vitro in the two glioma cell lines when combined with GCV exposure, while control nanoparticles encoding GFP maintained robust cell viability. For in vivo evaluation, tumor-bearing rats were treated with PBAE/HSVtk infusion via convection-enhanced delivery (CED) in combination with systemic administration of GCV. These treated animals showed a significant benefit in survival (p = 0.0012 vs control). Moreover, following a single CED infusion, labeled PBAE nanoparticles spread completely throughout the tumor. This study highlights a nanomedicine approach that is highly promising for the treatment of malignant glioma
Su un caso di mola vescicolare ricorrente con malattia trofoblastica persistente
Viene riportato il caso di una paziente di 30 anni, nullipara, con terza mola vescicolare consecutiva, trattata con tre revisioni di cavitĂ e tre cicli di chemioterapia con methotrexate per malattia trofoblastica persistente. Sono discussi gli attuali orientamenti sulla patogenesi delle forme familiari ricorrenti e la possibile terapia per quelle pazienti con mola ricorrente che non siano portatrici di anomalie genetiche specifiche
SCHIFF BASE COMPLEXES OF OXOCATIONS Part II Oxovanadium(IV) complexes with tetradentate optically active Schiff bases
NecesitĂ di ua valutazione epidemioogica dell'efficacia di campgne di informazione sanitaria e di interventi di educazione sessuale
verrĂ inserit
NecessitĂ di una valutazione epidemiologica dell'efficacia di campagne di infromazione sanitaria e di interventi di educazione sessuale.
Asymmetric synthesis of beta-phenylserines by condensation of benzaldehyde with zinc(II) and copper(II) complexes of (1R)-3-hydroxymethylenebornan-2-one glycine imines
The condensation between benzaldehyde and the zinc(II) and copper(II) complexes of the glycine imines of (1R)-3-hydroxymethylenebornan-2-one in the presence of strong bases has been studied. The diastereo- and enantio-selectivity of the reaction together with the spectroscopic characterization of the metal complexes and the corresponding enolate intermediates are reported
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