Coaxial carbon plasma gun deposition of amorphous carbon films

A unique plasma gun employing coaxial carbon electrodes was used in an attempt to deposit thin films of amorphous diamond-like carbon. A number of different structural, compositional, and electrical characterization techniques were used to characterize these films. These included scanning electron microscopy, scanning transmission electron microscopy, X ray diffraction and absorption, spectrographic analysis, energy dispersive spectroscopy, and selected area electron diffraction. Optical absorption and electrical resistivity measurements were also performed. The films were determined to be primarily amorphous, with poor adhesion to fused silica substrates. Many inclusions of particulates were found to be present as well. Analysis of these particulates revealed the presence of trace impurities, such as Fe and Cu, which were also found in the graphite electrode material. The electrodes were the source of these impurities. No evidence of diamond-like crystallite structure was found in any of the film samples. Details of the apparatus, experimental procedure, and film characteristics are presented

Electrotherapy in the treatment of patients affected by rabies: Experiments conducted at the maggiore hospital of Milan in 1865,Elektroterapija u lijeenju pacijenata zaraenih bjesnoom: Pokusi provoeni u bolnici maggiore u milanu tijekom 1865. godine

During the nineteenth century, the scientific context of rabies treatment was weak due to the lack of the literature on specific nosology of the rabies disease, and unspecific and ineffective therapy approaches. Electrotherapy already represented an important therapeutic approach for nervous system diseases, although not specifically for rabies. In the present paper, the authors discuss the use of electrotherapy in the treatment of humans affected by rabies in an experimental study conducted at the Maggiore Hospital of Milan, with the aim of establishing the discovery of a possible specific therapy. By analyzing the printed scientific sources available in the Braidense Library of Milan, the authors describe four experiments conducted on patients of different ages. Symptoms and effects both during and after the electrotherapy are also highlighted. The experiments demonstrated that electricity is not an effective therapy in the treatment of rabies, being rather able to cause serious functional and organic alterations in all the patients. Analyzing the Milanese experiments, the authors reported specific Italian history of a scientific and medical approach to rabies at the end of the 18th century, which led to the promotion of health education, reinforced prevention strategies and opened the way to the vaccination era

Prospective and retrospective performance assessment of Advanced Driver Assistance Systems in imminent collision scenarios: the CMI-Vr approach

Structured abstract Introduction Prospective and retrospective performance assessment of Advanced Driver Assistance Systems (ADASs) is fundamental to pilot future enhancements for active safety devices. In critical road scenarios between two vehicles where ADAS activation enables collision mitigation only, currently available assessment methodologies rely on the reconstruction of the impact phase consequent to the specific intervention on braking and steering: the velocity change sustained by the vehicle in the collision ($$\Delta V$$ Δ V ) is retrieved, so that IR decrease for the vehicle occupants can be obtained by appropriate Injury Risk (IR) models. However, information regarding the ADAS performance is available only after the impact phase reconstruction and not just as when the criticality occurs in the pre-impact phase: the best braking and steering alternative cannot be immediately envisaged, since a direct correlation lacks between the braking/steering intervention and IR. Method This work highlights an ADAS performance assessment method based on the disaggregation of $$\Delta V$$ Δ V in the two pre-impact parameters closing velocity at collision ($$V_r$$ V r ) and impact eccentricity, represented by the Crash Momentum Index (CMI). Such a disaggregation leads to the determination of IR based solely on impact configuration between the vehicles, without directly considering the impact phase. The performance of diverse ADASs in terms of intervention logic are directly comparable based on the resulting impact configuration, associated with a single coordinate in the CMI-$$V_r$$ V r plane and a sole IR value as a consequence. Results The CMI-$$V_r$$ V r approach is employable for both purposes of prospective and retrospective performance assessment of ADAS devices. To illustrate the advantages of the methodology, a solution for prospective assessment based on the CMI-$$V_r$$ V r plane is initially proposed and applied to case studies: this provides direct suggestions regarding the most appropriate interventions on braking and steering for IR minimization, fundamental in the tuning or development phase of an ADAS. A method for retrospective assessment is ultimately contextualized in the EuroNCAP "Car-to-Car Rear moving" test for an Inter-Urban Autonomous Emergency Braking system, a device implemented on a significant portion of the circulating fleet. Conclusions Based on the evidenced highlights, it is demonstrated that the approach provides complementary information compared to well-established performance assessment methodologies in all stages of an ADAS life cycle, by suggesting a direct physical connection in the pre-impact phase between the possible ADAS interventions and the foreseeable injury outcomes

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities

Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the markers that identify those capacities. Here we show that the secreted protein acidic and rich in cysteine (SPARC) identifies in both human and mouse MDSC with immune suppressive capacity and pro-tumoral activities including the induction of epithelial-to-mesenchymal transition (EMT) and angiogenesis. In mice the genetic deletion of SPARC reduced MDSC immune suppression and reverted EMT. Sparc−/− MDSC were less suppressive overall and the granulocytic fraction was more prone to extrude neutrophil extracellular traps (NET). Surprisingly, arginase-I and NOS2, whose expression can be controlled by STAT3, were not down-regulated in Sparc−/− MDSC, although less suppressive than wild type (WT) counterpart. Flow cytometry analysis showed equal phosphorylation of STAT3 but reduced ROS production that was associated with reduced nuclear translocation of the NF-kB p50 subunit in Sparc−/− than WT MDSC. The limited p50 in nuclei reduce the formation of the immunosuppressive p50:p50 homodimers in favor of the p65:p50 inflammatory heterodimers. Supporting this hypothesis, the production of TNF by Sparc−/− MDSC was significantly higher than by WT MDSC. Although associated with tumor-induced chronic inflammation, TNF, if produced at high doses, becomes a key factor in mediating tumor rejection. Therefore, it is foreseeable that an unbalance in TNF production could skew MDSC toward an inflammatory, anti-tumor phenotype. Notably, TNF is also required for inflammation-driven NETosis. The high level of TNF in Sparc−/− MDSC might explain their increased spontaneous NET formation as that we detected both in vitro and in vivo, in association with signs of endothelial damage. We propose SPARC as a new potential marker of MDSC, in both human and mouse, with the additional feature of controlling MDSC suppressive activity while preventing an excessive inflammatory state through the control of NF-kB signaling pathway

First application of the Trojan Horse Method with a Radioactive Ion Beam: study of the 18^{18}F(p,αp,{\alpha})15^{15}O}} reaction at astrophysical energies

Measurement of nuclear cross sections at astrophysical energies involving unstable species is one of the most challenging tasks in experimental nuclear physics. The use of indirect methods is often unavoidable in this scenario. In this paper the Trojan Horse Method is applied for the first time to a radioactive ion beam induced reaction studying the $^{18}$F($p,{\alpha}$)$^{15}$O process at low energies relevant to astrophysics via the three body reaction $^{2}$H($^{18}$F,${\alpha}^{15}$O)n. The knowledge of the $^{18}$F($p, {\alpha}$)$^{15}$O reaction rate is crucial to understand the nova explosion phenomena. The cross section of this reaction is characterized by the presence of several resonances in $^{19}$Ne and possibly interference effects among them. The results reported in Literature are not satisfactory and new investigations of the $^{18}$F($p,{\alpha}$)$^{15}$O reaction cross section will be useful. In the present work the spin-parity assignments of relevant levels have been discussed and the astrophysical S-factor has been extracted considering also interference effectsComment: 7 pages, 4 figure

Nuclear astrophysics and resonant reactions: Exploring the threshold region with the Trojan Horse Method

Resonant reactions play an important role in astrophysics as they might significantly enhance the cross section with respect to the direct reaction contribution and alter the nucleosynthetic flow. Moreover, resonances bear information about states in the intermediate compound nucleus formed in the reaction. However, nuclear reactions in stars take place at energies well below [Formula: see text] MeV and the Coulomb barrier, exponentially suppressing the cross section, and the electron screening effect, due to the shielding of nuclear charges by atomic electrons, make it very difficult to provide accurate input data for astrophysics. Therefore, indirect methods have been introduced; in particular, we will focus on the Trojan Horse Method. We will briefly discuss the theory behind the method, to make clear its domain of applicability, the advantages and the drawbacks, and two recent cases will be shortly reviewed: the [Formula: see text] reaction, which is an important fluorine destruction channel in the proton-rich outer layers of asymptotic giant branch (AGB) stars, and the [Formula: see text] reactions, which play a critical role in astrophysics to understand stellar burning scenarios in carbon-rich environments

Exploring the photothermo-catalytic performance of brookite tio2-ceo2 composites

The thermocatalytic, photocatalytic and photothermo-catalytic oxidation of some volatile organic compounds (VOCs), 2-propanol, ethanol and toluene, was investigated over brookite TiO2-CeO2 composites. The multi-catalytic approach based on the synergistic effect between solar photocatalysis and thermocatalysis led to the considerable decrease in the conversion temperatures of the organic compounds. In particular, in the photothermo-catalytic runs, for the most active samples (TiO2-3 wt% CeO2 and TiO2-5 wt% CeO2). the temperature at which 90% of VOC conversion occurred was about 60◦ C, 40◦ C and 20◦ C lower than in the thermocatalytic tests for 2-propanol, ethanol and toluene, respectively. Furthermore. the addition of cerium oxide to brookite TiO2 favored the total oxidation to CO2 already in the photocatalytic tests at room temperature. The presence of small amounts of cerium oxide allowed to obtain efficient brookite-based composites facilitating the space charge separation and increasing the lifetime of the photogenerated holes and electrons as confirmed by the characterization measurements. The possibility to concurrently utilize the photocatalytic properties of brookite and the redox properties of CeO2, both activated in the photothermal tests, is an attractive approach easily applicable to purify air from VOCs