O conceito de criação de territórios de desenvolvimento socioeconômico avançado

The article is devoted to the development of the concept of creation and functioning of the advanced socio-economic development territories. The relevance of the study is due to the need to develop the theoretical aspects of creating a new development institution in view of the lack of consensus between theorists and practitioners regarding both the need for a special form of a special territory and the mechanisms for achieving the goals. The hypothesis of the study is that the space of basic features, within which the formation of the advanced socio-economic development territories should be considered, can be structured on the basis of the dichotomous method.On the basis of diagnostics of indicators (2011-2016) of the socio-economic development of monocities and Far Eastern territories that have received the status of territories with a special mode of introducing entrepreneurial activity, and analysis of Russian legislation, national and foreign experience of territorial development, the authors constructed a problematic field for the creation of advanced socio-economic development in the form of a system of basic variables. The proposed conceptual model is designed to focus attention on the elaboration of the theoretical foundation for the creation of advanced socio-economic development territories, to limit and rationally optimize the process of their creation and functioning so that the government officials receive an effective mechanism for structuring the main stages of the state project implementation on creating a territory with a special introduction mode of business activities.El artículo está dedicado al desarrollo del concepto de creación y funcionamiento de los territorios de desarrollo socioeconómico avanzado. La relevancia del estudio se debe a la necesidad de desarrollar los aspectos teóricos de la creación de una nueva institución de desarrollo en vista de la falta de consenso entre los teóricos y los profesionales con respecto a la necesidad de una forma especial de territorio especial y los mecanismos para lograr las metas. La hipótesis del estudio es que el espacio de características básicas, dentro del cual debe considerarse la formación de territorios de desarrollo socioeconómico avanzado, puede estructurarse sobre la base del método dicotómico.Sobre la base del diagnóstico de los indicadores (2011-2016) del desarrollo socioeconómico de las ciudades y territorios del Lejano Oriente que han recibido el estatus de territorios con un modo especial de introducción de actividades empresariales, y análisis de la legislación rusa, experiencia nacional y extranjera. De desarrollo territorial, los autores construyeron un campo problemático para la creación de un desarrollo socioeconómico avanzado en forma de un sistema de variables básicas. El modelo conceptual propuesto está diseñado para centrar la atención en la elaboración de los fundamentos teóricos para la creación de territorios de desarrollo socioeconómico avanzado, para limitar y optimizar racionalmente el proceso de su creación y funcionamiento para que los funcionarios del gobierno reciban un mecanismo eficaz para estructurar las etapas principales de la implementación del proyecto estatal para crear un territorio con un modo especial de introducción de actividades comerciales.O artigo é dedicado ao desenvolvimento do conceito de criação e funcionamento dos territórios avançados de desenvolvimento socioeconômico. A relevância do estudo deve-se à necessidade de desenvolver os aspectos teóricos da criação de uma nova instituição de desenvolvimento, tendo em vista a falta de consenso entre teóricos e profissionais sobre a necessidade de uma forma especial de território especial e os mecanismos para alcançar a objetivos. A hipótese do estudo é que o espaço das características básicas, dentro do qual a formação dos territórios avançados de desenvolvimento socioeconômico deve ser considerado, pode ser estruturado com base no método dicotômico.Com base no diagnóstico de indicadores (2011-2016) do desenvolvimento socioeconômico de monocidades e territórios do Extremo Oriente que receberam o status de territórios com um modo especial de introduzir a atividade empreendedora, e análise da legislação russa, experiência nacional e estrangeira do desenvolvimento territorial, os autores construíram um campo problemático para a criação de desenvolvimento socioeconômico avançado na forma de um sistema de variáveis básicas. O modelo conceitual proposto visa chamar a atenção para a elaboração dos fundamentos teóricos para a criação de territórios avançados de desenvolvimento socioeconômico, para limitar e racionalizar o processo de sua criação e funcionamento, para que os funcionários públicos recebam um mecanismo efetivo de estruturação. as principais etapas da implementação do projeto estadual na criação de um território com um modo especial de introdução de atividades empresariais

Hemostatic Agents for the Management of Bleeding Risk Associated with Oral Anticoagulant Therapy Following Tooth Extraction: A Systematic Review

The occurrence of bleeding following dental extraction is a relatively common complication. A history of therapy with oral anticoagulants represents a major favoring factor, both in patients treated with vitamin K-antagonists (especially warfarin) and with direct oral anticoagulants (DOACs). Several local hemostatic measures can be applied to limit the bleeding risk in these patients. The aim of this systematic review is to evaluate what measures can be adopted to limit the bleeding risk following dental extractions in patients treated with oral anticoagulants. A literature search was performed, and 116 articles were retrieved. Titles and abstract analyses excluded 91 articles, and three more articles were excluded following full-text analysis. The systematic review was performed on 22 articles. Among the included articles, 20 studies reported on patients treated with warfarin, and two studies on patients treated with DOACs. The agents employed included local intra-alveolar agents, tranexamic acid, and PRF. The included studies were all at moderate/high risk of bias. Moreover, limited evidence is available on hemostasis in patients treated with DOACs. The available evidence hinders stating the superiority of one agent over the others. Further research is advised to increase the level of evidence of the application of hemostatic agents in patients treated with oral anticoagulants

RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection. Methods: RNA interference (RNAi)-induced knockdown of transcripts was used to investigate the role of ten tick proteins in the LGTV infection cycle in ISE6 cells. LGTV-infected cells were separately transfected with dsRNA corresponding to each gene of interest and the effect on LGTV genome replication and release of infectious virus was assessed by RT-qPCR and plaque assays, respectively. Results: RNAi-induced knockdown of transcripts for two enzymes that likely function in amino acid, carbohydrate, lipid, terpenoid/polykeytide and vitamin metabolism, and a transcript for one protein of unknown function were associated with decreased replication of the LGTV genome and release of infectious virus from cells. The knockdown of transcripts for five enzymes predicted to function in metabolism, a protein likely associated with folding, sorting and degradation, and a protein of unknown function was associated with a decrease only in the amount of infectious LGTV released from cells. Conclusions: These data suggest tick proteins potentially associated with metabolism and protein processing may be involved in LGTV infection of ISE6 cells. Our study provides information to begin to elucidate the function of these proteins and identify targets for the development of new interventions aimed at controlling the transmission of TBFs

O conceito e os meios de controle de processos de aglomeração

Within this article, we considered the theoretical and empirical approaches to the understanding of agglomeration processes, highlighted the main foreign and domestic paradigms for classifying territories as agglomerations, as well as studied the works of the authors who first introduced the concept of “agglomeration”. It has been found that the foreign authors most often interpret the concept according to geographical, administrative and economic approaches, while the domestic literature uses an economic-geographical appr oach. At the same time, the formation of agglomerations is based on the development potential of territories, and the agglomeration processes actively influence the factors of a territory development.At the present stage of development of agglomerations abroad, the potential and effectiveness of the agglomeration processes based on the benchmarking research are being actively studied. At the same time, foreign scientists identify various aspects for controlling the agglomeration development process. The article highlights the problem of the lack of the agglomeration development concept in Russia at the federation level, which hampers the development of relevant documents at the regional and territorial levels. The development of this concept is proposed to begin with the scheme of regulatory and legal support for the agglomeration development. There are three interrelated stages in the proposed scheme: the development of a specific agglomeration development strategy, the creation of a scheme for its territorial planning, the formation of a comprehensive investment program for agglomeration.En este artículo, consideramos los enfoques teóricos y empíricos para la comprensión de los procesos de aglomeración, destacamos los principales paradigmas extranjeros y nacionales para clasificar los territorios como aglomeraciones, y estudiamos los trabajos de los autores que introdujeron por primera vez el concepto de "aglomeración". Se ha encontrado que los autores extranjeros a menudo interpretan el concepto de acuerdo con los enfoques geográficos, administrativos y económicos, mientras que la literatura nacional utiliza un enfoque económico-geográfico. Al mismo tiempo, la formación de aglomeraciones se basa en el potencial de desarrollo de los territorios, y los procesos de aglomeración influyen activamente en los factores del desarrollo de un territorio.En la etapa actual del desarrollo de aglomeraciones en el extranjero, se están estudiando activamente el potencial y la eficacia de los procesos de aglomeración basados en la investigación de evaluación comparativa. Al mismo tiempo, científicos extranjeros identifican varios aspectos para controlar el proceso de desarrollo de la aglomeración. El artículo destaca el problema de la falta del concepto de desarrollo de aglomeración en Rusia a nivel de federación, lo que dificulta el desarrollo de documentos relevantes a nivel regional y territorial. Se propone el desarrollo de este concepto para comenzar con el esquema de apoyo legal y regulatorio para el desarrollo de la aglomeración. Hay tres etapas interrelacionadas en el esquema propuesto: el desarrollo de una estrategia específica de desarrollo de aglomeración, la creación de un esquema para su planificación territorial, la formación de un programa de inversión integral para la aglomeración.Dentro deste artigo, consideramos as abordagens teóricas e empíricas para a compreensão dos processos de aglomeração, destacamos os principais paradigmas nacionais e estrangeiros para classificar os territórios como aglomerações, bem como estudamos os trabalhos dos autores que primeiro introduziram o conceito de “aglomeração”. Verificou-se que os autores estrangeiros interpretam mais frequentemente o conceito de acordo com abordagens geográficas, administrativas e econômicas, enquanto a literatura nacional utiliza uma abordagem econômico-geográfica. Ao mesmo tempo, a formação de aglomerações baseia-se no potencial de desenvolvimento dos territórios, e os processos de aglomeração influenciam ativamente os fatores de desenvolvimento de um território.No estágio atual de desenvolvimento de aglomerações no exterior, o potencial e a eficácia dos processos de aglomeração baseados na pesquisa de benchmarking estão sendo ativamente estudados. Ao mesmo tempo, cientistas estrangeiros identificam vários aspectos para controlar o processo de desenvolvimento da aglomeração. O artigo destaca o problema da falta do conceito de desenvolvimento da aglomeração na Rússia no nível da federação, o que dificulta o desenvolvimento de documentos relevantes nos níveis regional e territorial. O desenvolvimento deste conceito é proposto para começar com o esquema de apoio regulatório e legal para o desenvolvimento da aglomeração. Há três estágios inter-relacionados no esquema proposto: o desenvolvimento de uma estratégia específica de desenvolvimento de aglomeração, a criação de um esquema para seu planejamento territorial, a formação de um programa abrangente de investimento para aglomeração

Exciton formation and relaxation in GaAs epilayers

Exciton formation and relaxation in GaAs bulk epilayers have been studied by means of time-resolved photoluminescence techniques. It is found that the time evolution of the free exciton luminescence, nonresonantly excited at low temperature and low intensity, is extremely slow, with a rise time of the order of 1 ns and a decay time of several ns. Simulations based on Monte Carlo solution of the set of coupled Boltzmann-like equations for free carriers and excitons show a nice agreement with the experimental data, and suggest a dominant role played by acoustic phonons in the exciton relaxation

Influence of Coulomb and Phonon Interaction on the Exciton Formation Dynamics in Semiconductor Heterostructures

A microscopic theory is developed to analyze the dynamics of exciton formation out of incoherent carriers in semiconductor heterostructures. The carrier Coulomb and phonon interaction is included consistently. A cluster expansion method is used to systematically truncate the hierarchy problem. By including all correlations up to the four-point (i.e. two-particle) level, the fundamental fermionic substructure of excitons is fully included. The analysis shows that the exciton formation is an intricate process where Coulomb correlations rapidly build up on a picosecond time scale while phonon dynamics leads to true exciton formation on a slow nanosecond time scale.Comment: 18 pages, 7 figure

Pape satan aleppe

Ġabra ta’ poeżiji u proża li tinkludi: Qniepen idoqqu ta’ W. Gulia – Wara l-laqgħa ta’ Dun Abbondju mal-bravi ta’ Dun Pawl – Il-poeżija tiegħi ta’ Ġużè Chetcuti – Tfajjel sajjied ta’ Vincent Caruana – Huma kollox! ta’ Ġer. Azzopardi – Dun Mikiel Xerri ta’ Ġino Muscat-Azzopardi – Quddiem għalqa tal-bittieħ ta’ A. Buttigieg – Montecatini ta’ A. Cremona – Bluha ta’ mument ta’ Jos. Cassar Pullicino – Pape satan aleppe ta’ Albert M. Cassola.N/

Y RNA: an overview of their role as potential biomarkers and molecular targets in human cancers

Y RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were published, mostly scattered across different tumor types and, in some cases, also suffering from methodological limitations. Nonetheless, these sparse data may be used to make some estimations and suggest routes to better understand the role of Y RNA in cancer formation and characterization. Here we summarize the current knowledge about Y RNA in multiple types of cancer, also including a paragraph about tumors that might be included in this list in the future, if more evidence becomes available. The picture arising indicates that Y RNA might be useful in tumor characterization, also relying on non-invasive methods, such as the analysis of the content of extracellular vesicles (EV) that are retrieved from blood plasma and other bodily fluids. Due to the established role of Y RNA in DNA replication, it is possible to hypothesize their therapeutic targeting to inhibit cell proliferation in oncological patients

Genomic Insights Into the Ixodes Scapularis Tick Vector of Lyme Disease

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ~57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host \u27questing\u27, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent

Non-coding RNAs and endometrial cancer

Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the neoplastic cells have been suggested. The significance of ncRNAs in lung cancer, bladder cancer, kidney cancer, and melanoma has been amply investigated with important results. Recently, the role of long non-coding RNAs (lncRNAs) has also been included in cancer studies. Studies on the relation between endometrial cancer (EC) and ncRNAs, such as small ncRNAs or micro RNAs (miRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), antisense RNAs (asRNAs), small nuclear RNAs (snRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), competing endogenous RNAs (ceRNAs), lncRNAs, and long intergenic ncRNAs (lincRNAs) have been published. The recent literature produced in the last three years was extracted from PubMed by two independent readers, which was then selected for the possible relation between ncRNAs, oncogenesis in general, and EC in particular