The influence of LED lighting on the development of Monarda L. in the conditions of hydroponics

The article presents the results of a study of the significance of the influence of the white and combined (red-blue-white) light spectrum on the growth and productivity of plants of the genus Monarda L. in the conditions of hydroponics. The optimal lighting mode has been found for the highest productivity of the monarda. A quantitative analysis of the content of photosynthetic pigments was carried out. The yield, leaf size and content of photosynthetic pigments in monarda leaves when grown under white LED lamps turned out to be higher than under colored ones

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

The influence of LED lighting on the development of

The article presents the results of a study of the significance of the influence of the white and combined (red-blue-white) light spectrum on the growth and productivity of plants of the genus Monarda L. in the conditions of hydroponics. The optimal lighting mode has been found for the highest productivity of the monarda. A quantitative analysis of the content of photosynthetic pigments was carried out. The yield, leaf size and content of photosynthetic pigments in monarda leaves when grown under white LED lamps turned out to be higher than under colored ones