El miedo a madurar en mujeres con obesidad mórbida postgastrectomía: predictores clínicos.

Analizar la conducta alimentaria en pacientes que son sometidos a cirugía bariátrica. Material y Método: Se administró el Eating Disorder Inventory (EDI) a 85 mujeres con obesidad mórbida intervenidas de cirugía gástrica (gastroplastia vertical bandeada) para perder peso. Resultados: La edad de las pacientes antes de la cirugía y la edad de inicio de la obesidad se relaciona con el Miedo a Madurar del EDI, de forma que cuanto mayor es el paciente y más tarde aparece la obesidad, el miedo a crecer es más intenso. Discusión: Estos hallazgos irían en la dirección de dependencia, inmadurez y miedo a crecer descritos en la población con obesidad mórbida.

Aspectos clínicos del trastorno por atracón o "binge eating disorder".

El trastorno por atracón es un nuevo trastorno alimentario que consiste en episodios repetidos de atracones de comida sin realizar mecanismos compensatorios para evitar ganar peso, como ocurre en la bulimia nerviosa. Analizamos las características clínicas (conducta alimentaria, psicopatología e imagen corporal), instrumentos de medida y tratamiento para el manejo del trastorno por atracó

Aspectos clínicos del trastorno por atracón o "binge eating disorder".

El trastorno por atracón es un nuevo trastorno alimentario que consiste en episodios repetidos de atracones de comida sin realizar mecanismos compensatorios para evitar ganar peso, como ocurre en la bulimia nerviosa. Analizamos las características clínicas (conducta alimentaria, psicopatología e imagen corporal), instrumentos de medida y tratamiento para el manejo del trastorno por atracó

Aspectos clínicos del trastorno por atracón o "binge eating disorder".

El trastorno por atracón es un nuevo trastorno alimentario que consiste en episodios repetidos de atracones de comida sin realizar mecanismos compensatorios para evitar ganar peso, como ocurre en la bulimia nerviosa. Analizamos las características clínicas (conducta alimentaria, psicopatología e imagen corporal), instrumentos de medida y tratamiento para el manejo del trastorno por atracó

El miedo a madurar en mujeres con obesidad mórbida postgastrectomía: predictores clínicos.

Analizar la conducta alimentaria en pacientes que son sometidos a cirugía bariátrica. Material y Método: Se administró el Eating Disorder Inventory (EDI) a 85 mujeres con obesidad mórbida intervenidas de cirugía gástrica (gastroplastia vertical bandeada) para perder peso. Resultados: La edad de las pacientes antes de la cirugía y la edad de inicio de la obesidad se relaciona con el Miedo a Madurar del EDI, de forma que cuanto mayor es el paciente y más tarde aparece la obesidad, el miedo a crecer es más intenso. Discusión: Estos hallazgos irían en la dirección de dependencia, inmadurez y miedo a crecer descritos en la población con obesidad mórbida.

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality