The European Modern Pollen Database (EMPD) project

Modern pollen samples provide an invaluable research tool for helping to interpret the quaternary fossil pollen record, allowing investigation of the relationship between pollen as the proxy and the environmental parameters such as vegetation, land-use, and climate that the pollen proxy represents. The European Modern Pollen Database (EMPD) is a new initiative within the European Pollen Database (EPD) to establish a publicly accessible repository of modern (surface sample) pollen data. This new database will complement the EPD, which at present holds only fossil sedimentary pollen data. The EMPD is freely available online to the scientific community and currently has information on almost 5,000 pollen samples from throughout the Euro-Siberian and Mediterranean regions, contributed by over 40 individuals and research groups. Here we describe how the EMPD was constructed, the various tables and their fields, problems and errors, quality controls, and continuing efforts to improve the available dat

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Informe oficial que rinde el Vicario Apostólico de los Llanos de San Martín al Excelentísimo Delegado Apostólico

Informe redactado por el obispo José María Guiot, vicario de los Llanos de San Martín, es una relación sobre las Misiones de los Llanos de San Martín (Colombia), en el que da cuenta de las labores misionales que se desarrollaron en la región entre octubre de 1810 y 1811.I. Creación y límites del Vicariato Apostólico de San Martín II. Desarrollo de la Misión III. Estado actual de la Misión IV. Ligeras apuntaciones sobre los indios de Los Llanos V. Labores de los Misioneros entre los blancos y los indígenas VI. Recientes expediciones de los Misioneros VII. Trabajos de los Misioneros como Inspectores de Instrucción pública VIII. Las Hermanas Hijas de la Sabiduría IX. Entradas y gastos de la Misión en el año de 1910-1911 X. Porvenir de la Misió

Informe que rinde a la Junta de Misiones de Colombia

Informe presentado por José María Guiot, vicario de los Llanos de San Martín (Colombia), a la junta de Misiones del país. En el documento Guiot compila varios informes que recibió de parte de otros líderes misionales de la región oriental del país, a partir de los cuales puede informar acerca de los costos, gastos, avances y dificultades que tuvieron los proyectos misionales en la región entre el 20 de julio de 1915 y 1916. A lo largo del documento aparecen varias fotografías de los sacerdotes encargados de las misiones.- Informe que rinde a la junta de misiones el vicario apostólico de los llanos de San Martín. - Estudio sobre el Banco San José. - Carta del Ilmo. Sr. Vicario apostólico al R. P. director del Banco San José

MedECC 2020 summary for policymakers

Virtually all sub-regions of the Mediterranean Basin, on land and in the sea, are impacted by recent anthropogenic changes in the environment. The main drivers of change include climate (tempera-ture, precipitation, atmospheric circulation, extreme events, sea-level rise, sea water temperature, salinity and acidification), population increase, pollution, unsustainable land and sea use practices and non-indigenous species. In most areas, both natural ecosystems and human livelihoods are af-fected. Due to global and regional trends in the drivers, impacts will be exacerbated in the coming decades, especially if global warming exceeds 1.5 to 2°C above the pre-industrial level. Significantly enhanced efforts are needed in order to adapt to inevitable changes, mitigate change drivers and increase resilience.info:eu-repo/semantics/publishedVersio

SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells

Two sarcoendoplasmic reticulum Ca(2+)-ATPases, SERCA3 and SERCA2b, are expressed in pancreatic islets. Immunocytochemistry showed that SERCA3 is restricted to beta-cells in the mouse pancreas. Control and SERCA3-deficient mice were used to evaluate the role of SERCA3 in beta-cell cytosolic-free Ca(2+) concentration ([Ca(2+)](c)) regulation, insulin secretion, and glucose homeostasis. Basal [Ca(2+)](c) was not increased by SERCA3 ablation. Stimulation with glucose induced a transient drop in basal [Ca(2+)](c) that was suppressed by inhibition of all SERCAs with thapsigargin (TG) but unaffected by selective SERCA3 ablation. Ca(2+) mobilization by acetylcholine was normal in SERCA3-deficient beta-cells. In contrast, [Ca(2+)](c) oscillations resulting from intermittent glucose-stimulated Ca(2+) influx and [Ca(2+)](c) transients induced by pulses of high K(+) were similarly affected by SERCA3 ablation or TG pretreatment of control islets; their amplitude was increased and their slow descending phase suppressed. This suggests that, during the decay of each oscillation, the endoplasmic reticulum releases Ca(2+) that was pumped by SERCA3 during the upstroke phase. SERCA3 ablation increased the insulin response of islets to 15 mmol/l glucose. However, basal and postprandial plasma glucose and insulin concentrations in SERCA3-deficient mice were normal. In conclusion, SERCA2b, but not SERCA3, is involved in basal [Ca(2+)](c) regulation in beta-cells. SERCA3 becomes operative when [Ca(2+)](c) rises and is required for normal [Ca(2+)](c) oscillations in response to glucose. However, a lack of SERCA3 is insufficient in itself to alter glucose homeostasis or impair insulin secretion in mice