Dichloridobis(4-pyridylmethyl 1H-pyrrole-2-carboxyl­ate-κN)zinc

In the title mol­ecule, [ZnCl2(C11H10N2O2)2], the ZnII ion, situated on a twofold axis, is in a distorted tetra­hedral coordination environment formed by two chloride anions and two pyridine N atoms of the two organic ligands. In the pyrrole-2-carboxyl­ate unit, the pyrrole N—H group and the carbonyl group point approximately in the same direction. The dihedral angle between the two pyridine rings is 54.8 (3)°. The complex mol­ecules are connected into chains extending along [101] by N—H⋯Cl hydrogen bonds. The chains are further assembled into (-101) layers by C—H⋯O and C—H⋯Cl inter­actions

meso-5,5′-Bis[(4-fluoro­phen­yl)diazen­yl]-2,2′-(pentane-3,3-di­yl)di-1H-pyrrole

There are two independent molecules in the asymmetric unit of the title compound, C25H24F2N6, in which the N=N bonds adopt a trans configuration with distances in the range 1.262 (2)–1.269 (3) Å. The dihedral angles between heterocycles are 86.7 (2) and 85.6 (2)° in the two molecules while the dihedral angles between the heterocylic rings and the adjacent benzene rings are 13.4 (2) and 13.4 (2)° in one molecule and 5.3 (2) and 6.5 (2)° in the other. In the crystal, pairs of independent mol­ecules are held together by four N—H⋯N hydrogen bonds, forming inter­locked dimers

Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia

Objective. Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia. Methods. We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized controlled trials (RCT) of stem cell transplantation for the ischemic stroke. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Thereafter, meta-analysis was performed. Results. Sixteen studies and eighteen independent treatments were included in the current meta-analysis. The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64-2.51; I2 = 57 %; p = 0.001), motor function (FMA, MD = 4.23; 95% CI, 3.08-5.38; I2 = 0 %; p <0.00001), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83-11.91; I2 = 63 %; p <0.00001), and functional independence (FIM, MD = 8.89; 95% CI, 4.70-13.08; I2 = 79 %; p <0.0001). Conclusions. It is suggested that the stem cell transplantation therapy for patients with brain ischemic stroke can significantly improve the neurological deficits and daily life quality, with no serious adverse events. However, higher quality and larger data studies are required for further investigation to support clinical application of stem cell transplantation

2-(4-Chloro-N-{2-[(1H-pyrrol-2-yl)carbon­yloxy]eth­yl}anilino)ethyl 1H-pyrrole-2-carboxyl­ate

In the title mol­ecule, C20H20ClN3O4, both the pyrrole N—H groups adopt a syn conformation with respect to the carbonyl groups. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into layers parallel to (102)

Simultaneous removal of NO and Hg⁰ using Fe and Co co-doped Mn-Ce/TiO₂ catalysts

Fe and Co co-doped Mn-Ce/TiO2 (MCT) catalysts were investigated for the simultaneous removal of nitric oxide (NO) and elemental mercury (Hg0) at reaction temperature lower than 200 °C. The catalysts were characterized by Brunauer–Emmett–Teller (BET), temperature program reduction (TPR), scanning electron microscope (SEM), x-ray diffraction (XRD) and x-ray photoelectron spectroscopy (XPS) analysis. The experimental results showed that the co-doped 2Fe4Co-MCT catalyst exhibited better performance for the simultaneous removal of NO and Hg0 compared to Fe or Co doped catalysts. This could be due to higher BET surface area and better redox property of 2Fe4Co-MCT catalyst. In addition, we propose that chemisorbed O2 played a dominant role in selective catalytic reduction (SCR) of NO while lattice O2 played a key role in Hg0 oxidation. The results also indicate that the introduction of Fe species enhanced the activity of SCR, whereas the introduction of Co species enhanced the oxidation of Hg0. The synergistic effect of Fe and Co species in the 2Fe4Co-MCT catalyst are also suggested to be an important mechanism for simultaneously removing NO and Hg0

Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116012/1/adfm201502868.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/116012/2/adfm201502868-sup-0001-S1.pd

Fertilization drives distinct biotic and abiotic factors in regulating functional groups of protists in a 5-year fertilization system

IntroductionProtists play an important role in nutrient cycling, microbiome stability and soil fertility maintenance. However, the driving force of protistan functional groups remains poorly understood in agricultural ecosystems.MethodsWe investigated the impacts of fertilization regimes on the diversity, composition and functional groups of protists and further disentangled the effects of multiple factors shaping the community composition of functional groups in a 5-year fertilization regime (CK, no fertilization; M, organic fertilization; MNPK, combined inorganic and organic fertilization; NPK, inorganic fertilization).ResultsFertilization significantly changed the community composition of protists rather than diversity. The MNPK treatment significantly increased the relative abundance of phototrophs and decreased that of the parasites and consumers. Partial least squares path modeling indicated that fertilization indirectly regulated protistan consumers via changes in the P content, which affected the composition of consumers mainly by regulating fungal community composition. Soil moisture (SM) and available phosphorus (AP) were identified as the top predictors for the composition of parasites, and the composition of phototrophs was mainly affected by SM, indicating that parasites and phototrophs were more sensitive to abiotic factors in the fertilization system.DiscussionTaken together, our findings highlight that fertilization significantly affects the composition of functional groups of protists and their biotic or abiotic regulatory processes, which have implications for the potential changes in their ecosystem functions for soil management systems