7 research outputs found
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69-0.82; P = 4.46 Ă 10(-10)), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 Ă 10(-3); combined P = 1.00 Ă 10(-11)). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions
De quatre tableaux attribués à Léonard de Vinci, dans lesquels la Sainte-Vierge, assise, se penche vers son enfant qui joue avec un agneau, mais en deux desquels est intercalée une sainte Anne / dissertation de l'abbé Aimé Guillon de Montléon,...
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Les martyrs de la foi pendant la RĂ©volution française, ou Martyrologe des pontifes, prĂȘtres, religieux, religieuses, laĂŻcs de l'un et l'autre sexe qui pĂ©rirent alors pour la foi. Volume 4 / : par M. l'abbĂ© AimĂ© Guillon,...
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Nouvelle lettre Ă M. Lamourette, Ă©vĂȘque du dĂ©partement de RhĂŽne-et-Loire, du 15 juin 1782 ([Reprod.]) / [par A. Guillon]
Collection : Les archives de la Révolution française ; 8.141