First nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX)

BACKGROUND: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg. METHOD: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30% and a proportion of 5% of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Both univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme. RESULTS: A total of 1432 subjects took part in the survey, yielding a participation rate of 32.2%. This figure is higher than the minimal sample size of 1285 subjects as estimated by power calculation. The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. All prevalence rates increased with age (except smoking) with marked gender differences (except diabetes). There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth. The proportion of subjects cumulating two or more cardiovascular risk factors increased remarkably with age and was more predominant in men than in women (P<0.0001). Only 14.7% of men and 23.1% of women were free of any cardiovascular risk factor. High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population. CONCLUSION: The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors. From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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Impact of Paraclinical Investigations in the Management of CAR T-Cell-Associated Neurotoxicity: Lessons Learned from Real World Experience

International audienc

Hair Repigmentation With Anti-PD-1 and Anti-PD-L1 Immunotherapy: A Novel Hypothesis

International audienceThe article by Rivera et al is the first report of a previously undescribed side effect of checkpoint inhibitors: hair repigmentation (HR). In this significant case series of 14 patients, all patients received an anti–programmed cell death 1 (PD-1) and anti–programmed cell death 1 ligand 1 (PD-L1) antibody for the treatment of a lung cancer..

T-cell Redirecting Therapies for the Treatment of B-cell Lymphomas: Recent Advances

T-cell specificity can be redirected against tumor antigens either ex vivo using engineered chimeric antigen receptor (CAR) T-cells or in vivo by bridging natural T-cells and tumor cells with bispecific T-cell engager (TCE) antibodies. Currently, four CAR T-cells have been approved by the FDA for the treatment of B-cell lymphomas, including diffuse large B cell lymphomas (DLBCL), mantle cell lymphoma (MCL), and follicular lymphoma (FL). No TCE have yet been approved for the treatment of B-cell lymphomas. However, at least four of them are in clinical development and show promising activity. Here, we review the most recent advances of CAR T-cells and TCE in the treatment of B-cell lymphomas

Immune effector cell-associated acute stroke: A novel entity?

International audience[No abstract available

Fleury-sur-Orne (parc d’Activités, Parcelle Zl13), Contribution à l’analyse spatiale et fonctionnelle d’un établissement rural laténien situé sur la Plaine de Caen (calvados)

La fouille du site de Fleury-sur-Orne Parc d’activités, parcelle ZL13 intervient dans le cadre de l’aménagement d’un parc d’Activités. Son occupation s’insère au sein d’un établissement rural laténien plus vaste exploré par plusieurs opérations AFAN. Cet établissement est occupé de La Tène ancienne à la transition avec la période gallo-romaine. La parcelle ZL13 a livré trois enclos à vocation domestique dont l’évolution peut être divisée en six phases. Une nécropole à caractère familial d’une trentaine de sépultures y est implantée dès La Tène ancienne. Les enclos sont bordés de fosses d’extraction de lœss, peut-être plus anciennes, et comportent des structures de stockages diversifiées (silo, celliers, caves boisées et cave souterraine) ainsi qu’une dizaine de structures de combustion. Le mobilier comporte de la faune, des graines et un ensemble de « petit mobilier ». Le corpus céramique a fait l’objet d’une étude typologique et d’analyses pétrographiques.The excavation of the site of Fleury-sur-Orne Parc d’activités, parcelle ZL13 preceded the development of an industrial and business park. Its occupation fits within a larger rural Second Iron Age establishment which has been investigated over several AFAN operations. This establishment was occupied from early La Tène until the transition to the Gallo-Roman period. Parcelle ZL13 revealed three domestic enclosures, in which six phases could be recognized. A family cemetery of around thirty graves developed there from early La Tène times. The enclosures were bordered by extraction pits for loess, perhaps earlier in date, and contain a variety of storage features (storage pits, cellars, wood-lined cellars and souterrains) as well as about ten hearth features. The finds include faunal remains, seeds and a small number of tools. The pottery was the subject of a typological study and petrographic analyses

Fleury-sur-Orne (Parc d’Activités, Parcelle ZL13) : contribution à l’analyse spatiale et fonctionnelle d’un établissement rural laténien situé sur la Plaine de Caen (Calvados)

International audienceThe excavation of the site of Fleury-sur-Orne Parc d’activités, parcelle ZL13 preceded the development of an industrial and business park. Its occupation fits within a larger rural Second Iron Age establishment which has been investigated over several AFAN operations. This establishment was occupied from early La Tène until the transition to the Gallo-Roman period. Parcelle ZL13 revealed three domestic enclosures, in which six phases could be recognized. A family cemetery of around thirty graves developed there from early La Tène times. The enclosures were bordered by extraction pits for loess, perhaps earlier in date, and contain a variety of storage features (storage pits, cellars, wood-lined cellars and souterrains) as well as about ten hearth features. The finds include faunal remains, seeds and a small number of tools. The pottery was the subject of a typological study and petrographic analyses.La fouille du site de Fleury-sur-Orne Parc d’activités, parcelle ZL13 intervient dans le cadre de l’aménagement d’un parc d’Activités. Son occupation s’insère au sein d’un établissement rural laténien plus vaste exploré par plusieurs opérations Fan. Cet établissement est occupé de La Tène ancienne à la transition avec la période gallo-romaine. La parcelle ZL13 a livré trois enclos à vocation domestique dont l’évolution peut être divisée en six phases. Une nécropole à caractère familial d’une trentaine de sépultures y est implantée dès La Tène ancienne. Les enclos sont bordés de fosses d’extraction de lœss, peut-être plus anciennes, et comportent des structures de stockages diversifiées (silo, celliers, caves boisées et cave souterraine) ainsi qu’une dizaine de structures de combustion. Le mobilier comporte de la faune, des graines et un ensemble de « petit mobilier ». Le corpus céramique a fait l’objet d’une étude typologique et d’analyses pétrographiques

Prolonged thrombocytopenia after CAR T-cell therapy: the role of thrombopoietin receptor agonists

International audienceNo abstract availabl