Immunological Aspects of Psoriasis: V.T. Cell Subsets and Suppressor Cell Functions Regulating Immune Responses in Peripheral Blood

T cell subsets bearing Fc-receptors for either IgG (TG) or IgM (TM), and suppressor cell activity of peripheral blood mononuclear cells on in vitro lymphoproliferative response were studied in patients with untreated psoriasis. The proportions of TG and TM cells were unmodified in 15 patients compared to 15 control subjects studied in parallel experiments. The concanavalin A-induced suppressor cell activity, as well as the spontaneous suppressor cell function of in vitro short-lived adherent cells, were in the normal range for 7 out of 8 psoriatic patients investigated. The data argue against the possibility that a generalized suppressor cell defect occurs in psoriasis

Los partidos políticos y la constitución.

La constitucionalización de los partidos políticos se ha producido lentamente. Cuando decimos constitucionalización nos referimos al cons- titucionalismo moderno que nace en el siglo XVIII, o sea, al que entiende que existe constitución si ella formalmente, por escrito, asegura las ga- rantías de los derechos y determina la separación de los poderes

Revolución americana y las sesiones secretas deCádiz

El artículo analiza las respuestas que ofrecieron las Cortes de Cádiz a la Revolución hispanoamericana de 1810, que sublevó importantes territorios del Nuevo Mundo sometidos al yugo de la Monarquía hispánica. El estudio revela cómo en las sesiones secretas de las Cortes se apostaba por la solución bélica para reprimir y reconducir a la unidad de la monarquía a aquellos territorios que no reconocían la autoridad del Gobierno de la metrópoli y que se habían declarado soberanos e independientes como Caracas, Chile, Quito, Buenos Aires, Santa Fe, etcétera, mientras que con otros menos subversivos se mantuvo la vía del diálogo y la conciliación.The article analyzes the answers that offered Cortes from Cadiz to the hispano-American Revolution of 1810, which it incited to rebellion important territories of the New World submissive the yoke of the Hispanic Monarchy. The study reveals how in the secret sessions of Courts it was bet by the warlike solution to repress and to lead back to the unit from the monarchy to those territories that did not recognize the authority of the Government of the metropolis and which they had been declared sovereign and independent like Caracas, Chile, Quito, Buenos Aires, Santa Fe, etcetera, whereas with others less rebels stayed the route of the dialogue and the conciliation

El nuevo orden jurídico político instaurado el 24 de marzo de 1976.

El gobierno de facto surgido del golpe militar del 24 de marzo de 1976 ha producido suficiente número de medidas de relevancia como para que, a más de cuatro meses de su actuación, podamos intentar perfilar el régimen político instaurado y las notas más salientes de ese sistema frente a los diversos interrogantes que puede plantearse la teo­ría política y constitucional

Vicente Fidel López - político e historiador : (1815-1903)

Fil: Hualde de Pérez Guilhou, Margarita. Universidad Nacional de Cuyo. Facultad de Filosofía y Letra

C-fos and c-jun Proto-Oncogene Expression Is Decreased in Psoriasis: an In Situ Quantitative Analysis

Psoriasis is a common, sometimes sevcre, non-malignant skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes. Because proto-oncogenes are implicated in both cell proliferation and differentiation, their expression could be modified in skin diseases such as psoriasis. The c-fos and c-jun proto-oncogenes, whose products associate to form a heterodimeric transcription factor, are among the first genes to be expressed when certain cells are stimulated to either proliferate or differentiate. Recent studies in our laboratory have shown that the c-fos protooncogene is highly expressed in normal human adult skin. In the present study, we used in situ hybridization with RNA to compare the expression and localization of c-fos and c-jun transcripts in 15 lesional and non-lesional psoriatic skin samples. Two clinical variants of psoriasis were studied: the most severe and chronic form or plaque-type psoriasis (N = 10) and rapidly resolutive guttate-type psoriasis (N = 5). Quantitative analysis was performed using a semi-automatic image analyzer and the “Starwise grain” software program. Our control samples included 10 normal skins and eight specimens from other benign hyperproliferative non-psoriatic skin diseases, consisting of three with inflammation (seborrheic dermatitis and atopic dermatitis), and 5 without inflammation (seborrheic keratoses). Control genes we used for in situ hybridization and RNA integrity were keratin 14, which is expressed in the epidermis and was normally expressed in all tissue analyzed, and ribosomal RNA. Our data showed that c-fos and c-jun were expressed to an equivalent extent, both spatially and quantitatively, in all specimens tested. Expression was significantly decreased in plaque-type but not in guttate-type psoriasis. It was also decreased in the three other benign inflammatory cutaneous hyperproliferative disorders, but not in the five non-inflammatory cases. These results were surprising because hyperproliferation was here associated with a decrease in proto-oncogene expression, thus suggesting that c-fos and c-jun do not play a crucial role in the control of keratinocyte proliferation in vivo. However, their reduced expression in some abnormally differentiated skins indicates that both c-fos and c-jun proto-oncogenes may play a key role in keratinocyte differentiation. Their altered expression correlated with severity of the disease and the presence of an inflammatory infiltrate. These data offer a new insight into the role and regulation of these proto-oncogenes in vivo in humans

Las dos visitas de Ortega y Gasset a Mendoza

Fil: Hualde de Pérez Guilhou, Margarita. Universidad Nacional de Cuyo. Facultad de Filosofía y LetrasFil: Bronislawa Duda, Marta. Universidad Nacional de Cuyo. Facultad de Filosofía y Letra

La lucha contra la tuberculosis en la provincia de Mendoza

Fil: Hualde de Pérez Guilhou, Margarita. Universidad Nacional de Cuyo. Facultad de Filosofía y LetrasFil: Gorayeb de Perinetti, Yasmin. Universidad Nacional de Cuyo. Facultad de Filosofía y LetrasFil: Perinetti, Carlos E.. Universidad Nacional de Cuyo. Facultad de Filosofía y Letra

Perspectivas para el desarrollo de la telesalud en la Universidad Juan Agustín Maza

TeleSalud es la utilización de tecnologías de información y comunicaciones (TICs) para proporcionar servicios e información en salud; derribando las barreras geográficas y temporales, con el objetivo final de contribuir al mejoramiento de la salud de la Población. Por Resolución del Ministerio de Salud 399/2011, se crea la Red Provincial de TeleSalud (RPTM) con la participación de la Universidad Nacional de Cuyo, la Universidad del Aconcagua, la Universidad de Mendoza, la Universidad Juan Agustín Maza, el Ministerio de Salud de la Provincia, el Instituto Zaldívar y el Polo Tecnológico de Mendoza