A note on the comparison of some randomized response procedures

Abstract The paper reconsiders and compares some randomized response models in the light of the efficiency/protection criterion. The results show that, despite the assertion of the authors about the superiority of their methods, some procedures are perfectly equivalent to theWarner’s or the Simmons’models. Ourwork extends and generalizes the results of Bhargava and Singh [2002. On the efficiency comparison of certain randomized response strategies. Metrika 55, 191–197] and other authors

Prevalence of tracheobronchomalacia and excessive dynamic airway collapse in bronchial asthma of different severity

BACKGROUND: Tracheobronchomalacia (TBM) is a pathologic condition in which softening of tracheal and bronchial cartilage causes the dynamic narrowing of transverse or sagittal diameters of tracheobronchial lumen; an excessive dynamic airway collapse (EDAC) may also be associated, with a substantial invagination of the posterior membrane of trachebronchial tree. The aim of this study was to assess the prevalence of both TBM and EDAC in a population of asthmatics with different degrees of disease severity compared to a reference group of subjects without any bronchial obstruction. METHODS: A cohort of 202 asthmatics was investigated by means of a dynamic flexible videobronchoscopy: 74 mild persistent (MPA - age 18–68 ys; 35 males; mean FEV(1) = 88.6% pred. ± 8.3 sd); 63 moderate (MA - age 21–71 ys; 30 males; mean FEV(1) = 71.3% pred. ± 9.1 sd), 65 severe asthmatics (SA - age 33–70 ys; 25 males; mean FEV(1) = 48.5% pred. ± 7.6 sd), and 62 non obstructed subjects (NO - age 18–71 ys; 38 males; mean FEV(1) 98.6% pred. ± 2.7 sd). TBM and EDAC were classified according to FEMOS classification. RESULTS: TBM and EDAC were observed in only 1/62 subjects (both 1.61%) of NO group, while their prevalence was 2.70% and 6.75% in MPA group; 7.93% and 19.04% in MA group; 18.46% and 69.23% in SA group, respectively. The crude prevalence of thyroid disorders in the population was 12.9%. In particular, the prevalence of thyroid disorders was significantly higher in females than in men, but 54-fold higher in females than in men in the presence of EDAC. CONCLUSIONS: 1) The prevalence of both TBM and EDAC is directly related to age, gender (females), and asthma severity; 2) EDAC is much more frequent than TBM in all asthma patients; 3) both tracheal abnormalities proved to be more represented in asthmatics with thyroid disorders, and particularly in female asthmatics with EDAC

Lamellar macular defects: are degenerative lamellar macular holes truly degenerative?

PurposeTo investigate morpho-functional changes after surgical treatment for ERM foveoschisis or lamellar macular hole (LMH), and to evaluate whether the two entities are associated with different healing processes and long-term outcomes.DesignRetrospective interventional case series.MethodsA total of 56 eyes, treated for lamellar macular defects and followed up for 24 months, were enrolled. The eyes were divided into two groups: 34 with ERM foveoschisis and 22 with LMH. Changes in the following features were evaluated and compared between the two groups: best-corrected visual acuity (BCVA), external limiting membrane (ELM) and ellipsoid zone (EZ) defects, central foveal thickness (CFT), and autofluorescence (FAF) diameter and area.ResultsAfter surgery, progressive BCVA improvement was observed with no significant difference between the two groups (p-value: 0.06). An increased number of eyes with intact outer-retinal layers was found both in the ERM foveoschisis and LMH groups. FAF diameter and area decreased significantly throughout the FU with no significant difference between the two groups (p-value: 0.2).ConclusionIn the present study, significant functional and microstructural improvements were observed after surgery for both ERM foveoschisis and LMH, demonstrating considerable repair potential in both types of lamellar defects. These findings question the true “degenerative” nature of LMH

Two efficient procedures to correct the positioning errors in the plane-polar scanning

Two techniques to effectively compensate known positioning errors in a plane-polar near-field–far-field (NF–FF) transformation, using a minimum number of NF data and adopting an oblate ellipsoid to shape the considered antenna, are proposed and validated through experimental proofs. The former makes use of the singular value decomposition method to recover the voltage samples which would be acquired by the probe at the points fixed by the non-redundant sampling representation from the collected positioning error affected ones, whereas the latter employs an iterative scheme. The NF data required by the classical NF–FF transformation with plane-rectangular scanning are then efficiently evaluated via a two-dimensional optimal sampling interpolation formula. The effectiveness of the proposed techniques is assessed by experimental tests performed at the Antenna Characterisation Lab of the University of Salerno

Near-Field/Far-Field Transformation with Helicoidal Scanning from Irregularly Spaced Data

A fast and accurate technique for the compensation of the probe positioning errors in the near-field/far-field transformation with helicoidal scanning is proposed in this paper. It relies on a nonredundant sampling representation using a spherical modelling of the antenna under test and employs an iterative scheme to evaluate the near-field data at the points fixed by the helicoidal nonredundant representation from the acquired irregularly distributed ones. Once these helicoidal data have been recovered, those required by a classical cylindrical near-field/far-field transformation are efficiently determined by using an optimal sampling interpolation algorithm. Some numerical tests assessing the effectiveness of the proposed approach and its stability with respect to random errors affecting the near-field data are shown

An Innovative Direct NF-FF Transformation Technique with Helicoidal Scanning

A direct near-field-far-field transformation with helicoidal scanning is developed. It is based on the nonredundant sampling representation of electromagnetic fields and uses a spherical antenna modelling to determine the number of helix turns. Moreover, the number of voltage samples on each of them is fixed by the maximum transverse dimension of the antenna, both to simplify the mechanical scanning and to reduce the computational effort. This technique allows the evaluation of the antenna far field directly from a minimum set of near-field data without interpolating them. Although the number of near-field data employed by the developed technique is slightly increased with respect to that required by rigorously applying the nonredundant sampling representation on the helix, it is still remarkably smaller than that needed by the standard near-field-far-field transformation with cylindrical scanning. The effectiveness of the technique is assessed by numerical and experimental results

Aspirin-dependent effects on purinergic P2Y1 receptor express

Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway activated by thromboxane-A2 receptor. We hypothesized that recovery of ADP-induced platelet activation could be attributed to increased P2Y1 expression induced by chronic aspirin exposure. We performed a multi-phase investigation which embraced both in vitro and in vivo experiments conducted in (1) human megakaryoblastic DAMI cells, (2) human megakaryocytic progenitor cell cultures, (3) platelets obtained from HVs treated with aspirin and (4) platelets obtained from aspirin-treated patients. DAMI cells treated with aspirin or WY14643 (PPARα agonist) had a significant up-regulation of P2Y1 mRNA, which was shown to be a PPARα-dependent process. In human megakaryocytic progenitors, in the presence of aspirin or WY14643, P2Y1 mRNA expression was higher than in mock culture. P2Y1 expression increased in platelets obtained from HVs treated with aspirin for 8 weeks. Platelets obtained from patients who were on aspirin for more than 2 months had increased P2Y1 expression and ADP-induced aggregation compared with patients on aspirin treatment for less than a month. Overall, our results suggest that aspirin induces genomic changes in megakaryocytes leading to P2Y1 up-regulation and that PPARα is the nuclear receptor involved in this regulation. Since P2Y1 is coupled to the same Gq-protein of thromboxane-A2 receptor, platelet adaptation in response to pharmacological inhibition seems not to be receptor specific, but may involve other receptors with the same biochemical pathway

Nutraceutical Characteristics of Ancient Malus x domestica Borkh. Fruits Recovered across Siena in Tuscany

Background: A diet rich in fruits and vegetables contributes to lowering the risk of chronic diseases. The fruits of Malus x domestica are a rich dietary source of bioactive compounds, namely vitamins and antioxidants, with recognized action on human health protection. Tuscany is known for its rich plant biodiversity, especially represented by ancient varieties of fruit trees. Particularly noteworthy are the many ancient Tuscan varieties of apple trees. Methods: Sugar quantification via HPLC and spectrophotometric assays to quantify the antioxidant power and total polyphenol content revealed interesting differences in 17 old varieties of Malus x domestica Borkh. recovered in Siena (Tuscany). Results: The quantification of antioxidants, polyphenols, and the main free sugars revealed that their content in the old fruits was often superior to the widespread commercial counterparts (‘Red Delicious’ and ‘Golden Delicious’). Such differences were, in certain cases, dramatic, with 8-fold higher values. Differences were also present for sugars and fibers (pectin). Most ancient fruits displayed low values of glucose and high contents of xylitol and pectin. Conclusions: The results reported here suggest the possible use of ancient apple varieties from Siena for nutraceutical purposes and draw attention to the valorization of local old varieties

Near-Field to Far-Field Transformation Techniques with Spiral Scannings: A Comprehensive Review

An overview of the near-field-far-field (NF-FF) transformation techniques with innovative spiral scannings, useful to derive the radiation patterns of the antennas commonly employed in the modern wireless communication systems, is provided in this paper. The theoretical background and the development of a unified theory of the spiral scannings for quasi-spherical and nonspherical antennas are described, and an optimal sampling interpolation expansion to evaluate the probe response on a quite arbitrary rotational surface from a nonredundant number of its samples, collected along a proper spiral wrapping it, is presented. This unified theory can be applied to spirals wrapping the conventional scanning surfaces and makes it possible to accurately reconstruct the NF data required by the NF-FF transformation employing the corresponding classical scanning. A remarkable reduction of the measurement time is so achieved, due to the use of continuous and synchronized movements of the positioning systems and to the reduced number of needed NF measurements. Some numerical and experimental results relevant to the spherical spiral scanning case when dealing with quasi-planar and electrically long antennas are shown

Far-Field Pattern Reconstruction from Near-Field Data Collected via a Nonconventional Plane-Rectangular Scanning: Experimental Testing

This paper deals with the experimental validation of an efficient near-field-far-field (NF-FF) transformation using the planar wide-mesh scanning (PWMS). Such a nonconventional plane-rectangular scanning technique is so named, since the sample grid is characterized by meshes wider and wider when going away from the center, and makes it possible to lower the number of needed measurements, as well as the time required for the data acquisition when dealing with quasi-planar antennas. It relies on the use of the nonredundant sampling representations of electromagnetic fields which employ an oblate ellipsoid or a surface formed by two circular "bowls" with the same aperture diameter but eventually different bending radii to shape a quasi-planar antenna. A two-dimensional optimal sampling interpolation formula allows the reconstruction of the NF data at any point on the measurement plane and, in particular, at those required by the classical NF-FF transformation with the conventional plane-rectangular scanning. The measurements, performed at the planar NF facility of the antenna characterization laboratories of Selex ES, have confirmed the effectiveness of this innovative scanning also from the experimental viewpoint