Governing governance:Collective action and rulemaking in EU agricultural and non-agricultural geographical indications

Geographical Indications (‘GIs’) designate a product whose reputation, characteristics and quality are essentially due to their geographical origin. They are identifiers of ‘origin products’, immersed in a specific local natural and socio-cultural ecosystem. Local tangible and intangible assets and the associated reputation are nurtured over time, but they are also vulnerable to erosion. GIs encourage stakeholders to codify arrangements (product specifications) as a response to this problem. The importance of collective action issues in GIs has been demonstrated by interdisciplinary scholarship. However, it is mostly considered extraneous in the legal discourse and in policy prescriptions at the European level. Through a transdisciplinary approach this work combines comparative legal and case study analyses, illustrating the diversity of the protection and valorisation strategies of French and Italian agricultural and non-agricultural origin products.Inspired by the theory and diagnostic frameworks of Elinor Ostrom’s and colleagues for analysing human cooperation for the sustainable governance of tangible and intangible commons, it explores the potential of the conceptual proximity between GIs and the commons reframing key aspects of GI legal theory and embracing the collective action perspective. The analysis of how actors’ interactions in rulemaking for product specification design affects the outcomes, reveals that the interpretation and implementation of national legal rules at the pre-registration and registration phases are not harmonised in Europe. Empirically grounded findings flag legally relevant collective action issues in GI settings and support suggestions for coherent policy transitions, measuring implementation feasibility and avoiding panaceas

Governing governance:Collective action and rulemaking in EU agricultural and non-agricultural geographical indications

Geographical Indications (‘GIs’) designate a product whose reputation, characteristics and quality are essentially due to their geographical origin. They are identifiers of ‘origin products’, immersed in a specific local natural and socio-cultural ecosystem. Local tangible and intangible assets and the associated reputation are nurtured over time, but they are also vulnerable to erosion. GIs encourage stakeholders to codify arrangements (product specifications) as a response to this problem. The importance of collective action issues in GIs has been demonstrated by interdisciplinary scholarship. However, it is mostly considered extraneous in the legal discourse and in policy prescriptions at the European level. Through a transdisciplinary approach this work combines comparative legal and case study analyses, illustrating the diversity of the protection and valorisation strategies of French and Italian agricultural and non-agricultural origin products.Inspired by the theory and diagnostic frameworks of Elinor Ostrom’s and colleagues for analysing human cooperation for the sustainable governance of tangible and intangible commons, it explores the potential of the conceptual proximity between GIs and the commons reframing key aspects of GI legal theory and embracing the collective action perspective. The analysis of how actors’ interactions in rulemaking for product specification design affects the outcomes, reveals that the interpretation and implementation of national legal rules at the pre-registration and registration phases are not harmonised in Europe. Empirically grounded findings flag legally relevant collective action issues in GI settings and support suggestions for coherent policy transitions, measuring implementation feasibility and avoiding panaceas

Dynamic, self consistent electro-thermal simulation of power microwave devices including the effect of surface metallizations

We present an efficient simulation technique to account for the thermal spreading effects of surface metallizations in the self-consistent dynamic electro-thermal analysis of power microwave devices. Electro-thermal self-consistency is achieved by solving the coupled nonlinear system made of a temperature dependent device electrical model, and of an approximate description of the device thermal behavior through a thermal impedance matrix. The numerical solution is pursued in the frequency domain by the Harmonic Balance technique. The approach is applied to the thermal stability analysis of power AlGaAs/GaAs HBTs and the results show that metallizations have a significant impact on the occurrence of the device thermal collapse

Physics-based large-signal sensitivity analysis of microwave circuits using technological parametric sensitivity from multidimensional semiconductor device models

The authors present an efficient approach to evaluate the large-signal (LS) parametric sensitivity of active semiconductor devices under quasi-periodic operation through accurate, multidimensional physics-based models. The proposed technique exploits efficient intermediate mathematical models to perform the link between physics-based analysis and circuit-oriented simulations, and only requires the evaluation of dc and ac small-signal (dc charge) sensitivities under general quasi-static conditions. To illustrate the technique, the authors discuss examples of sensitivity evaluation, statistical analysis, and doping profile optimization of an implanted MESFET to minimize intermodulation which makes use of LS parametric sensitivities under two-tone excitatio

An aceylcholinesterase/choline oxidase-based amperometric biosensor as a liquid chromatography detector for acetylcholine and choline determination in brain tissue

A liquid chromatography (LC) detector based on a fast response and sensitive bienzyme amperometric biosensor for acetylcholine (ACh) and choline (Ch) is described. The detector fabrication consisted of glutaraldehyde co-crosslinking of acetylcholinesterase and choline oxidase with bovine serum albumin on the Pt working electrode of a conventional thin-layer electrochemical flow cell. The influence of some experimental parameters (e.g. enzyme loading, thickness of the bienzyme layer, flow rate) on the detector characteristics has been studied in order to optimize the analyte response while minimizing band broadening and distortion. A mobile phase consisting of a phosphate buffer (I 0.1 M, pH 6.5) containing 5 mM sodium hexane sulphonate and 10 mM tetramethylammonium phosphate was found to give very satisfactory resolution and peak shape in ion-pair, reversed-phase LC. Linear responses were observed over at least four decades and absolute detection limits (at a signal to noise ratio of 3) were 12 and 27 fmole injected for Ch and ACh, respectively. After one month of intensive use in the LC system, the detector retained about 70% of its initial sensitivity. The potential of the described approach is demonstrated by the simultaneous determination of Ch and ACh in rat brain tissue homogenates

Ab initio simulations of Cu binding sites in the N-terminal region of PrP

The prion protein (PrP) binds Cu2+ ions in the octarepeat domain of the N-terminal tail up to full occupancy at pH=7.4. Recent experiments show that the HGGG octarepeat subdomain is responsible for holding the metal bound in a square planar coordination. By using first principle ab initio molecular dynamics simulations of the Car-Parrinello type, the Cu coordination mode to the binding sites of the PrP octarepeat region is investigated. Simulations are carried out for a number of structured binding sites. Results for the complexes Cu(HGGGW)+(wat), Cu(HGGG) and the 2[Cu(HGGG)] dimer are presented. While the presence of a Trp residue and a H2O molecule does not seem to affect the nature of the Cu coordination, high stability of the bond between Cu and the amide Nitrogens of deprotonated Gly's is confirmed in the case of the Cu(HGGG) system. For the more interesting 2[Cu(HGGG)] dimer a dynamically entangled arrangement of the two monomers, with intertwined N-Cu bonds, emerges. This observation is consistent with the highly packed structure seen in experiments at full Cu occupancy.Comment: 4 pages, conference proceedin

The observation of light nuclei at ALICE and the X(3872) conundrum

The new data reported by ALICE on the production of light nuclei with pT < 10 GeV in Pb-Pb collisions at sqrt(s_NN) = 2.76 TeV are used to compute an order-of-magnitude estimate of the expected production cross sections of light nuclei in proton-proton collisions at high transverse momenta. We compare the hypertriton, helium-3 and deuteron production cross sections to that of X(3872), measured in prompt pp collisions by CMS. The results we find suggest a different production mechanism for the X(3872), making questionable any loosely bound molecule interpretation.Comment: 5 pages, 2 figures. Version accepted on PR

Linking X Parameters to Physical Simulations for Design-Oriented Large-Signal Device Variability Modeling

We propose various techniques extending X parameters to include the effect of active microwave device variability by exploiting TCAD simulations. We discuss two possible implementations into Agilent ADS. Both approaches are validated against full microwave amplifier TCAD simulations