Inserción profesional: de la universidad al trabajo

Treball Final de Grau en Psicologia. Codi: PS1048. Curs acadèmic 2015-2016Tener trabajo hoy en día es una fuente de autoestima y realización, que satisface tanto a nivel profesional como personal. Los estudiantes y egresados universitarios finalizan sus estudios y se enfrentan a la transición de la universidad al trabajo, por ello, la preparación para la búsqueda de empleo es una tarea de importante desarrollo en el paso a la vida adulta. De modo que desde las Universidades y otras instituciones, se diseñan programas e intervenciones dirigidas a desarrollar la empleabilidad mediante acciones formativas. Por otro lado, desde la Teoría Social Cognitiva, se propone la Autoeficacia como un elemento clave en la agencia humana. En este contexto, el objetivo de este trabajo es, por una parte, estudiar el efecto de la formación en los usuarios, analizando las percepciones de satisfacción, desarrollo de empleabilidad y transferencia de la formación a la inserción propia. Por otro lado, analizar la relación de la Autoeficacia para la búsqueda de empleo con las experiencias de búsqueda e iniciativas de búsqueda mediante candidatura espontánea (antecedentes de autoeficacia) y el Locus de control. Los resultados del primer estudio referido a los Talleres de Formación muestran que los usuarios perciben estos Talleres de Formación como satisfactorios, valorándolos como útiles para su inserción profesional y les permite adquirir nuevas destrezas y conocimientos y con ello desarrollan su empleabilidad. En cuanto al segundo estudio referido a la muestra de Orientación Profesional, se constata que existe una relación positiva y significativa entre la Autoeficacia para la búsqueda de empleo, el Locus de control, y la iniciativa mediante candidatura espontánea. Estos resultados ponen de manifiesto la importancia de considerar el desarrollo de la autoeficacia como objetivo de la formación para la búsqueda de empleo.Having work today is a source of self-esteem and accomplishment, that satisfies both professionally as personal. Students and university graduates completed their studies and are facing the transition from University to work, therefore, preparation for the job search is a task of major development in the transition to adult life. So from the universities and other institutions, programmes and interventions aimed at developing employability through training activities are designed. On the other hand, from the Social cognitive theory, proposed self-efficacy as a key element in the human agency. In this context, the objective of this work is, firstly, to study the effect of training users, analyzing the perceptions of satisfaction, employability development and transfer of training to the own inclusion. Moreover, to analyze the relationship of self-efficacy for job searching with search experiences and initiatives of search through spontaneous application (a history of self-efficacy) and Locus of control. The results of the first study referred to training workshops show that users perceive these as satisfactory training workshops, valuing them as useful for professional insertion and allows them to acquire new skills and knowledge and thereby develop their employability. The second study referred to the sample of vocational guidance, it is noted that there is a positive and significant relationship between self-efficacy for job searching, Locus of control, and the initiative through spontaneous application. These results highlight the importance of considering the development of selfefficacy as an objective of the training for the job search

Evaluation of the host immune response assay SeptiCyte RAPID for potential triage of COVID-19 patients

Abstract Tools for the evaluation of COVID-19 severity would help clinicians with triage decisions, especially the decision whether to admit to ICU. The aim of this study was to evaluate SeptiCyte RAPID, a host immune response assay (Immunexpress, Seattle USA) as a triaging tool for COVID-19 patients requiring hospitalization and potentially ICU care. SeptiCyte RAPID employs a host gene expression signature consisting of the ratio of expression levels of two immune related mRNAs, PLA2G7 and PLAC8, measured from whole blood samples. Blood samples from 146 adult SARS-CoV-2 (+) patients were collected within 48 h of hospital admission in PAXgene blood RNA tubes at Hospital del Mar, Barcelona, Spain, between July 28th and December 1st, 2020. Data on demographics, vital signs, clinical chemistry parameters, radiology, interventions, and SeptiCyte RAPID were collected and analyzed with bioinformatics methods. The performance of SeptiCyte RAPID for COVID-19 severity assessment and ICU admission was evaluated, relative to the comparator of retrospective clinical assessment by the Hospital del Mar clinical care team. In conclusion, SeptiCyte RAPID was able to stratify COVID-19 cases according to clinical severity: critical vs. mild (AUC = 0.93, p < 0.0001), critical vs. moderate (AUC = 0.77, p = 0.002), severe vs. mild (AUC = 0.85, p = 0.0003), severe vs. moderate (AUC = 0.63, p = 0.05). This discrimination was significantly better (by AUC or p-value) than could be achieved by CRP, lactate, creatine, IL-6, or D-dimer. Some of the critical or severe cases had “early” blood draws (before ICU admission; n = 33). For these cases, when compared to moderate and mild cases not in ICU (n = 37), SeptiCyte RAPID had AUC = 0.78 (p = 0.00012). In conclusion, SeptiCyte RAPID was able to stratify COVID-19 cases according to clinical severity as defined by the WHO COVID-19 Clinical Management Living Guidance of January 25th, 2021. Measurements taken early (before a patient is considered for ICU admission) suggest that high SeptiScores could aid in predicting the need for later ICU admission

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field