Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper

Key summary points: Aim: To summarize the literature on medication review and deprescribing in older adults, and formulate recommendations to improve prescribing medications in older, multimorbid adults with polypharmacy. Findings: Current evidence demonstrates a need for a multifaceted and wide-scale change in education, guidelines, research, advocacy, and policy to improve the management of polypharmacy in older people, and to make deprescribing part of routine care for the ageing generations to come. Message: By implementing the recommendations in this paper, healthcare professionals will be better prepared to address the challenges associated with an ageing population and provide high-quality care to older patients with complex health and social care needs

REACTIVE OXYGEN SPECIES АND ANTIOXIDANT SYSTEM ОF PLANTS

Under the influence of adverse conditions reactive oxygen species (ROS) are formed, which lead to oxidative stress. Increasing the ROS content in plants can pose a threat to the cells, causing lipid peroxidation, oxidative damage to proteins, nucleic acids, as well as inhibition of enzymes, activation of the pathway of programmed cell death, and ultimately leading to cell death. Plants have a well developed defense system to counteract active forms of oxygen (ROS), including both limiting the formation of ROS and neutralizing them. Under normal conditions, the formation and degradation of the ROS are in equilibrium. At the same time, under stress, the antioxidant system can not cope with its task