1,054 research outputs found
20 Years Of Progress In Dengue Hemorrhagic Fever And Other Arboviral Diseases Research
Throughout the 20 year history of U.S. Naval Medical Research Unit No. 2 Detachment (NAMRU), many viruses and viral diseases have been studied. The greatest emphasis has been in the field of arboviruses, specifically dengue virus, chikungunya virus, and Japanese B encephalitis virus. The initial focus of the work was to define the extent of the threat posed by these viruses. Studies were conducted to determine antibody prevalence, and to determine the etiologies of infectious febrile disease in hospitalized patients. Later the work advanced into more specific areas, especially the entomologic and clinical components of these viruses. Little was known of the incidence or kind of arbovirus infections in Indonesia when NAMRU was established. Previous serological studies had used the cross reactive haemagglutination assay. Green et al. in 1973 provided convincing serological evidence of infections with chikungunya virus and group B arboviruses by using the specific virus neutralization assay. These results demonstrated the need for further studies to isolate the causative agent, to describe the epidemiology, and to investigate the clinical features of the associated disease
The , , and mesons in a double pole QCD Sum Rule
We use the method of double pole QCD sum rule which is basically a fit with
two exponentials of the correlation function, where we can extract the masses
and decay constants of mesons as a function of the Borel mass. We apply this
method to study the mesons: , , and
. We also present predictions for the toponiuns masses
of m(1S)=357 GeV and m(2S)=374 GeV.Comment: 14 pages, 11 figures in Braz J Phys (2016
Characterization of a dengue type-specific epitope on dengue 3 virus envelope protein domain III
Dengue virus (DENV) is a mosquito-borne disease caused by four genetically and serologically related viruses termed DENV-1, -2, -3 and -4. The DENV envelope (E) protein ectodomain can be divided into three structural domains designated ED1, ED2 and ED3. The ED3 domain contains DENV type-specific and DENV complex-reactive antigenic sites. To date, nearly all antigenic studies on the E protein have focused on DENV-2. In this study, the epitope recognized by a DENV-3 type-specific monoclonal antibody (mAb 14A4-8) was mapped to the DENV-3 ED3 domain using a combination of physical and biological techniques. Epitope mapping revealed that amino acid residues V305, L306, K308, E309, V310, K325, A329, G381 and I387 were critical for the binding of mAb 14A4-8 and amino acid residues T303, K307, K386, W389 and R391 were peripheral residues for this epitope. The location of the mAb 14A4-8 epitope overlaps with the DENV complex-reactive antigenic site in the DENV-3 ED3 domain
Multiple infarcted regenerative nodules in liver cirrhosis after decompensation of cirrhosis: a case series
These patients showed focal liver lesions, to be considered in the differential diagnosis of cirrhotic livers. Infarcted regenerative nodules may be underdiagnosed in patients with decompensation of cirrhosis. In order to differentiate these lesions from malignant tumors, serial imaging seems to be helpful. However, the main differential diagnosis should be an abscess. It is important to know the wide spectrum of image appearances of these lesions. Hypotension can lead to a reduction of portal and arterial liver flow. Since variceal bleeding or septic shock can induce hypotension - as observed in our patients - we conclude that this leads to infarction of such nodules
Barrier and internal wave contributions to the quantum probability density and flux in light heavy-ion elastic scattering
We investigate the properties of the optical model wave function for light
heavy-ion systems where absorption is incomplete, such as Ca
and O around 30 MeV incident energy. Strong focusing effects
are predicted to occur well inside the nucleus, where the probability density
can reach values much higher than that of the incident wave. This focusing is
shown to be correlated with the presence at back angles of a strong enhancement
in the elastic cross section, the so-called ALAS (anomalous large angle
scattering) phenomenon; this is substantiated by calculations of the quantum
probability flux and of classical trajectories. To clarify this mechanism, we
decompose the scattering wave function and the associated probability flux into
their barrier and internal wave contributions within a fully quantal
calculation. Finally, a calculation of the divergence of the quantum flux shows
that when absorption is incomplete, the focal region gives a sizeable
contribution to nonelastic processes.Comment: 16 pages, 15 figures. RevTeX file. To appear in Phys. Rev. C. The
figures are only available via anonynous FTP on
ftp://umhsp02.umh.ac.be/pub/ftp_pnt/figscat
High Precision Astrometry with MICADO at the European Extremely Large Telescope
In this article we identify and discuss various statistical and systematic
effects influencing the astrometric accuracy achievable with MICADO, the
near-infrared imaging camera proposed for the 42-metre European Extremely Large
Telescope (E-ELT). These effects are instrumental (e.g. geometric distortion),
atmospheric (e.g. chromatic differential refraction), and astronomical
(reference source selection). We find that there are several phenomena having
impact on ~100 micro-arcsec scales, meaning they can be substantially larger
than the theoretical statistical astrometric accuracy of an optical/NIR
42m-telescope. Depending on type, these effects need to be controlled via
dedicated instrumental design properties or via dedicated calibration
procedures. We conclude that if this is done properly, astrometric accuracies
of 40 micro-arcsec or better - with 40 micro-arcsec/year in proper motions
corresponding to ~20 km/s at 100 kpc distance - can be achieved in one epoch of
actual observationsComment: 15 pages, 9 figures, 3 tables. Accepted by MNRA
Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA
A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as well as discrimination of noncognate sequences, consistent with function as a Py mimic according to the Py/Im polyamide pairing rules
The Palomar Testbed Interferometer
The Palomar Testbed Interferometer (PTI) is a long-baseline infrared
interferometer located at Palomar Observatory, California. It was built as a
testbed for interferometric techniques applicable to the Keck Interferometer.
First fringes were obtained in July 1995. PTI implements a dual-star
architecture, tracking two stars simultaneously for phase referencing and
narrow-angle astrometry. The three fixed 40-cm apertures can be combined
pair-wise to provide baselines to 110 m. The interferometer actively tracks the
white-light fringe using an array detector at 2.2 um and active delay lines
with a range of +/- 38 m. Laser metrology of the delay lines allows for servo
control, and laser metrology of the complete optical path enables narrow-angle
astrometric measurements. The instrument is highly automated, using a
multiprocessing computer system for instrument control and sequencing.Comment: ApJ in Press (Jan 99) Fig 1 available from
http://huey.jpl.nasa.gov/~bode/ptiPicture.html, revised duging copy edi
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
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