IMPACT EXPERIMENTS IN ORTHOPAEDIC BIOMECHANICS

A better understanding of the fracture mechanism, kinematics of the anatomic structure and tissue tolerances can improve clinical prognosis and design of anthropomorphic test devices. An impact apparatus was designed to do experiments in vitro in the areas of orthopaedic biomechanics, either in hard tissue or soft tissue. METHODS: The specimens were subjected to high-speed trauma produced by an impact apparatus. This testing setup is a falling weight system which can do axial and eccentric impacts for different objectives of the orthopaedic studies. A special design was installed to assure only one impact on the specimen for biomechanical analysis. A high-speed camera was placed in front of the specimen to record the trauma event. In this study, the specimens included porcine vertebras, rabbit achilles tendons and human leg cadavers. Observations were also made to get more details by X-ray and/or by CT scan. RESULTS: Spinal fractures similar to those found clinically were successfully produced in porcine spines by impact testing. The deformations of the discs and the kinematical stability of the spinal experimental segments were also found. For the experiment on the achilles tendon, the high speed traction mechanism could produce strain injury to the specimen and get the immediate tensile force in the traction process. For the study on internal fixation for calcaneal fractures, clinically-relevant fractures under high speed impact were produced. The specimens with both longitudinal and transverse primary fracture lines were selected for simulated open reduction and internal fixation. All mechanical failures of the reconstructed calcanens occurred through the transverse primary fracture line. CONCLUSION: Impact experiment is a useful method to do fundamental research in orthopaedic biomechanics. The results in the animal model offer useful insight into bone fractures in human. The repeatability and reproducibility of animal tests offer a great opportunity to evaluate spinal fracture mechanics. The test on the achilles tendon injury was just a pilot study, and a well-designed protocol is needed to improve the results. The study on calcaneal fractures resulted in adding a longitudinal. Transfixing screw is recommended to enhance the strength of internal fixation in the presence of a transverse primary fracture line. From the above three studies, it was concluded that the impact method is an excellent experiment to produce tissue failure and/or fractures for further orthopaedic research

Design And Fabrication of Condenser Microphone Using Wafer Transfer And Micro-electroplating Technique

A novel fabrication process, which uses wafer transfer and micro-electroplating technique, has been proposed and tested. In this paper, the effects of the diaphragm thickness and stress, the air-gap thickness, and the area ratio of acoustic holes to backplate on the sensitivity of the condenser microphone have been demonstrated since the performance of the microphone depends on these parameters. The microphone diaphragm has been designed with a diameter and thickness of 1.9 mm and 0.6 $\mu$m, respectively, an air-gap thickness of 10 $\mu$m, and a 24% area ratio of acoustic holes to backplate. To obtain a lower initial stress, the material used for the diaphragm is polyimide. The measured sensitivities of the microphone at the bias voltages of 24 V and 12 V are -45.3 and -50.2 dB/Pa (at 1 kHz), respectively. The fabricated microphone shows a flat frequency response extending to 20 kHz.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

Cross-Modality Paired-Images Generation for RGB-Infrared Person Re-Identification

RGB-Infrared (IR) person re-identification is very challenging due to the large cross-modality variations between RGB and IR images. The key solution is to learn aligned features to the bridge RGB and IR modalities. However, due to the lack of correspondence labels between every pair of RGB and IR images, most methods try to alleviate the variations with set-level alignment by reducing the distance between the entire RGB and IR sets. However, this set-level alignment may lead to misalignment of some instances, which limits the performance for RGB-IR Re-ID. Different from existing methods, in this paper, we propose to generate cross-modality paired-images and perform both global set-level and fine-grained instance-level alignments. Our proposed method enjoys several merits. First, our method can perform set-level alignment by disentangling modality-specific and modality-invariant features. Compared with conventional methods, ours can explicitly remove the modality-specific features and the modality variation can be better reduced. Second, given cross-modality unpaired-images of a person, our method can generate cross-modality paired images from exchanged images. With them, we can directly perform instance-level alignment by minimizing distances of every pair of images. Extensive experimental results on two standard benchmarks demonstrate that the proposed model favourably against state-of-the-art methods. Especially, on SYSU-MM01 dataset, our model can achieve a gain of 9.2% and 7.7% in terms of Rank-1 and mAP. Code is available at https://github.com/wangguanan/JSIA-ReID.Comment: accepted by AAAI'2

Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells

We investigated the ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) in Ewing sarcoma cells, in the perspective of in vivo anti-cancer nucleic acid drug delivery. siRNA was adsorbed onto NDs previously coated with cationic polymer. Cell uptake of NDs has been demonstrated by taking advantage of NDs intrinsic fluorescence coming from embedded color center defects. Cell toxicity of these coated NDs was shown to be low. Consistent with the internalization efficacy, we have shown a specific inhibition of EWS/Fli-1 gene expression at the mRNA and protein level by the ND vectorized siRNA in a serum containing medium

Potential benefits of vitamin D for sepsis prophylaxis in critical ill patients

BackgroundVitamin D deficiency is common in critically ill patients with suspected infection and is strongly associated with the predisposition of sepsis and a poor prognosis. The effectiveness of vitamin D supplementation for preventing sepsis remains unclear. This retrospective cohort study investigated the effect of vitamin D supplementation on sepsis prophylaxis in critically ill patients with suspected infection.MethodsThis retrospective cohort study included 19,816 adult patients with suspected infection in intensive care units (ICU) from 2008 to 2019 at the Beth Israel Deaconess Medical Center, Boston, USA. The included patients were divided into the vitamin D cohort or non-vitamin D cohort according to vitamin D administration status. The primary outcomes were the incidence of sepsis in ICU. The secondary outcomes included 28-day all-cause mortality, length of ICU and hospital stay and the requirements of vasopressors or mechanical ventilation. A propensity score matching cohort was used to test the differences in primary and secondary outcomes between groups.ResultsThe results showed that vitamin D supplementation demonstrated a lower risk of sepsis (odd ratio 0.46; 95% CI 0.35–0.60; P < 0.001) and a lower risk of new mechanical ventilation requirement (odd ratio 0.70; 95% CI 0.53-0.92; P = 0.01), but no significant difference in the risk of 28-day mortality was observed (hazard ratio 1.02; 95% CI 0.77–1.35; P = 0.89). In the sensitive analysis, among the patients who suspected infection within 24 h before or after ICU admission, a lower risk of sepsis and a lower percentage of new mechanical ventilation also were detected in the vitamin D cohort.ConclusionVitamin D supplementation may have a positively prophylactic effect on sepsis in critically ill patients with suspected infection

Duration of Antibody Responses after Severe Acute Respiratory Syndrome

Among 176 patients who had had severe acute respiratory syndrome (SARS), SARS-specific antibodies were maintained for an average of 2 years, and significant reduction of immunoglobulin G–positive percentage and titers occurred in the third year. Thus, SARS patients might be susceptible to reinfection >3 years after initial exposure