Magnetic Phase Transitions in One-dimensional Strongly Attractive Three-Component Ultracold Fermions

We investigate the nature of trions, pairing and quantum phase transitions in one-dimensional strongly attractive three-component ultracold fermions in external fields. Exact results for the groundstate energy, critical fields, magnetization and phase diagrams are obtained analytically from the Bethe ansatz solutions. Driven by Zeeman splitting, the system shows exotic phases of trions, bound pairs, a normal Fermi liquid and four mixtures of these states. Particularly, a smooth phase transition from a trionic phase into a pairing phase occurs as the highest hyperfine level separates from the two lower energy levels. In contrast, there is a smooth phase transition from the trionic phase into a normal Fermi liquid as the lowest level separates from the two higher levels.Comment: 4 pages, 3 figures, minor revisions to text, replacement figure, refs added and update

Wilson ratio of Fermi gases in one dimension

We calculate the Wilson ratio of the one-dimensional Fermi gas with spin imbalance. The Wilson ratio of attractively interacting fermions is solely determined by the density stiffness and sound velocity of pairs and of excess fermions for the two-component Tomonaga-Luttinger liquid (TLL) phase. The ratio exhibits anomalous enhancement at the two critical points due to the sudden change in the density of states. Despite a breakdown of the quasiparticle description in one dimension, two important features of the Fermi liquid are retained, namely the specific heat is linearly proportional to temperature whereas the susceptibility is independent of temperature. In contrast to the phenomenological TLL parameter, the Wilson ratio provides a powerful parameter for testing universal quantum liquids of interacting fermions in one, two and three dimensions.Comment: 5+2 pages, 4+1 figures, Eq. (4) is proved, figures were refine

Universal local pair correlations of Lieb-Liniger bosons at quantum criticality

The one-dimensional Lieb-Liniger Bose gas is a prototypical many-body system featuring universal Tomonaga-Luttinger liquid (TLL) physics and free fermion quantum criticality. We analytically calculate finite temperature local pair correlations for the strong coupling Bose gas at quantum criticality using the polylog function in the framework of the Yang-Yang thermodynamic equations. We show that the local pair correlation has the universal value $g^{(2)}(0)\approx 2 p/(n\varepsilon)$ in the quantum critical regime, the TLL phase and the quasi-classical region, where $p$ is the pressure per unit length rescaled by the interaction energy $\varepsilon=\frac{\hbar^2}{2m} c^2$ with interaction strength $c$ and linear density $n$. This suggests the possibility to test finite temperature local pair correlations for the TLL in the relativistic dispersion regime and to probe quantum criticality with the local correlations beyond the TLL phase. Furthermore, thermodynamic properties at high temperatures are obtained by both high temperature and virial expansion of the Yang-Yang thermodynamic equation.Comment: 8 pages, 6 figures, additional text and reference

Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature

The Ewing's sarcoma cell line TC71 overexpresses vascular endothelial growth factor isoform 165 (VEGF165), a potent proangiogenic molecule that induces endothelial cell proliferation, migration, and chemotaxis. CD34+ bone marrow stem cells can differentiate into endothelial and hematopoietic cells. We used a transplant model to determine whether CD34 + cells migrate from the bone marrow to Ewing's sarcoma tumors and participate in the neovascularization process that supports tumor growth. We also examined the role of VEGF165 in CD34+ cell migration. Human umbilical cord CD34+ cells were transplanted into sublethally irradiated severe combined immunodeficient mice. Seven days later, the mice were injected subcutaneously with TC71 tumor cells. Tumors were excised 2 weeks later and analyzed by immunohistochemistry. The tumor sections expressed both human VE-cadherin and mouse CD31, indicating involvement of donor-derived human cells in the tumor vessels. To determine the role of VEGF165 in the chemoattraction of CD34+ cells, we generated two VEGF 165-deficient TC71 clones, a stable anti-sense VEGF165 cell line (Clone 17) and a VEGF165 siRNA-inhibited clone (TC/siVEGF7-1). The resulting VEGF165-deficient tumor cells had normal growth rates in vitro, but had delayed growth when implanted into mice. Immunohistochemical analysis revealed decreased infiltration of CD34+ cells into both VEGF165-deficient tumors. These data show that bone marrow stem cells contribute to the growing tumor vasculature in Ewing's sarcoma and that VEGF165 is critical for the migration of CD34+ cells from the bone marrow into the tumor. © 2006 Wiley-Liss, Inc.Fil: Lee, Tim H.. University of Texas; Estados UnidosFil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. University of Texas; Estados UnidosFil: Worth, Laura L.. University of Texas; Estados UnidosFil: Guan, Hui. University of Texas; Estados UnidosFil: Ellis, Lee M.. University of Texas; Estados UnidosFil: Kleinerman, Eugenie S.. University of Texas; Estados Unido

Wilson Ratio of Fermi gases in One Dimension

We calculate the Wilson ratio of the one-dimensional Fermi gas with spin imbalance. The Wilson ratio of attractively interacting fermions is solely determined by the density stiffness and sound velocity of pairs and of excess fermions for the two-compone

The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage

A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage. We found that the introduction of PB2 mutation with K at 627 but not K at 591 or N at 701 to the duck H7N9 virus led to increased pathogenicity in mice. We also found that the induction of pro-inflammatory cytokines including TNF-α, IP-10, MCP-1 and MIP-1α were associated with increased severity of infection. We conclude that introduction of the mammalian adaptation mutations into the PB2 gene of duck H7N9 viruses, which are genetically unrelated to the zoonotic H7N9 lineage, can also enhance pathogenicity in mice.published_or_final_versio

Thermodynamics, spin-charge separation and correlation functions of spin-1/2 fermions with repulsive interaction

We investigate the low temperature thermodynamics and correlation functions of one-dimensional spin-1/2 fermions with strong repulsion in an external magnetic field via the thermodynamic Bethe ansatz method. The exact thermodynamics of the model in a weak magnetic field is derived with the help of Wiener-Hopf techniques. It turns out that the low energy physics can be described by spin-charge separated conformal field theories of an effective Tomonaga-Luttinger liquid and an antiferromagnetic SU(2) Heisenberg spin chain. However, these two types of conformally invariant low-lying excitations may break down as excitations take place far away from the Fermi points. The long distance asymptotics of the correlation functions and the critical exponents for the model in the presence of a magnetic field at zero temperature are derived in detail by solving dressed charge equations and by conformal mapping. Furthermore, we calculate the conformal dimensions for particular cases of correlation functions. The leading terms of these correlation functions are given explicitly for a weak magnetic field $H\ll 1$ and for a magnetic field close to the critical field $H\rightarrow H_{c}$. Our analytical results provide insights into universal thermodynamics and criticality in one-dimensional many-body physics.Comment: revised version, 47 pages, 4 figures, additional tex

Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development

NCoA6 (also referred to as NRC, ASC-2, TRBP, PRIP and RAP250) was originally isolated as a ligand-dependent nuclear receptor interacting protein. However, NCoA6 is a multifunctional coregulator or coactivator necessary for transcriptional activation of a wide spectrum of target genes. The NCoA6 gene is amplified and overexpressed in breast, colon and lung cancers. NCoA6 is a 250 kDa protein which harbors a potent N-terminal activation domain, AD1; and a second, centrally-located activation domain, AD2, which is necessary for nuclear receptor signaling. The intrinsic activation potential of NCoA6 is regulated by its C-terminal STL regulatory domain. Near AD2 is an LxxLL-1 motif which interacts with a wide spectrum of ligand-bound NRs with high-affinity. A second LxxLL motif (LxxLL-2) located towards the C-terminal region is more restricted in its NR specificity. The potential role of NCoA6 as a co-integrator is suggested by its ability to enhance transcriptional activation of a wide variety of transcription factors and from its in vivo association with a number of known cofactors including CBP/p300. NCoA6 has been shown to associate with at least three distinct coactivator complexes containing Set methyltransferases as core polypeptides. The composition of these complexes suggests that NCoA6 may play a fundamental role in transcriptional activation by modulating chromatin structure through histone methylation. Knockout studies in mice suggest that NCoA6 is an essential coactivator. NCoA6-/- embryos die between 8.5-12.5 dpc from general growth retardation coupled with developmental defects in the heart, liver, brain and placenta. NCoA6-/- MEFs grow at a reduced rate compared to WT MEFs and spontaneously undergo apoptosis, indicating the importance of NCoA6 as a prosurvival and anti-apoptotic gene. Studies with NCoA6+/- and conditional knockout mice suggest that NCoA6 is a pleiotropic coregulator involved in growth, development, wound healing and maintenance of energy homeostasis

Versatile Phenotype-Activated Cell Sorting

Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with unique spatiotemporal profiles from heterogeneous populations. SPOTlight relies on imaging visual phenotypes by microscopy, precise optical tagging of single target cells, and retrieval of tagged cells by fluorescence-activated cell sorting. To illustrate SPOTlight\u27s ability to screen cells based on temporal properties, we chose to develop a photostable yellow fluorescent protein for extended imaging experiments. We screened 3 million cells expressing mutagenesis libraries and identified a bright new variant, mGold, that is the most photostable yellow fluorescent protein reported to date. We anticipate that the versatility of SPOTlight will facilitate its deployment to decipher the rules of life, understand diseases, and engineer new molecules and cells