Possibility of the tunneling time determination

We show that it is impossible to determine the time a tunneling particle spends under the barrier. However, it is possible to determine the asymptotic time, i.e., the time the particle spends in a large area including the barrier. We propose a model of time measurements. The model provides a procedure for calculation of the asymptotic tunneling and reflection times. The model also demonstrates the impossibility of determination of the time the tunneling particle spends under the barrier. Examples for delta-form and rectangular barrier illustrate the obtained results.Comment: 8 figure

Current-voltage characteristic and stability in resonant-tunneling n-doped semiconductor superlattices

We review the occurrence of electric-field domains in doped superlattices within a discrete drift model. A complete analysis of the construction and stability of stationary field profiles having two domains is carried out. As a consequence, we can provide a simple analytical estimation for the doping density above which stable stable domains occur. This bound may be useful for the design of superlattices exhibiting self-sustained current oscillations. Furthermore we explain why stable domains occur in superlattices in contrast to the usual Gunn diode.Comment: Tex file and 3 postscript figure

Urban nitrogen budgets: Evaluating and comparing the path of nitrogen through cities for improved management

Reactive nitrogen (Nr) released to the environment is a cause of multiple environmental threats. While Nr flows are often only analyzed in an agricultural context, consumption and emission takes place in the urban environment, and opportunities for Nr recycling and effective policy implementation for mitigation often appear in cities. Since little information is available on the bigger picture of Nr flows through the urban environment, these opportunities often remain unexploited. Here we developed a framework to model Nr pathways through urban and surrounding areas, which we applied to four test areas (Beijing and Shijiazhuang (China), Vienna (Austria), and Zielona Góra (Poland)). Using indicators such as recycling rates and Nr surplus, we estimated environmental risks and recycling potentials based on Nr flows and their entry and exit points. Our findings show marked differences between the core and surrounding areas of each city, with the former being a site of Nr consumption with largest flows associated with households, and the latter a site of (agricultural) production with largest flows associated with industry (fertilizers) and urban plants. As a result, Nr transgresses the core areas in a rather linear manner with only 0-5 % being re-used, with inputs from Nr contained in food and fuels and outputs most commonly as non-reactive N2 emissions to the atmosphere from wastewater treatment and combustion processes. While the peri-urban areas show a higher Nr recycling rate (6-14 %), Nr accumulation and emissions from cultivated land pose significant environmental challenges, indicating the need for mitigation measures. We found potential to increase nitrogen use efficiency through improved Nr management on cultivated areas and to increase Nr recycling using urine and sewage sludge as synthetic fertilizer substitutes. Hence our framework for urban nitrogen budgets not only allows for consistent budgeting but helps identify common patterns, potentially harmful flows and Nr recycling potential

Shared pooled mobility: expert review from nine disciplines and implications for an emerging transdisciplinary research agenda

Shared pooled mobility has been hailed as a sustainable mobility solution that uses digital innovation to efficiently bundle rides. Multiple disciplines have started investigating and analyzing shared pooled mobility systems. However, there is a lack of cross-community communication making it hard to build upon knowledge from other fields or know which open questions may be of interest to other fields. Here, we identify and review 9 perspectives: transdisciplinary social sciences, social physics, transport simulations, urban and energy economics, psychology, climate change solutions, and the Global South research and provide a common terminology. We identify more than 25 000 papers, with more than 100 fold variation in terms of literature count between research perspectives. Our review demonstrates the intellectual attractivity of this as a novel perceived mode of transportation, but also highlights that real world economics may limit its viability, if not supported with concordant incentives and regulation. We then sketch out cross-disciplinary open questions centered around (1) optimal configuration of ride-pooling systems, (2) empirical studies, and (3) market drivers and implications for the economics of ride-pooling. We call for researchers of different disciplines to actively exchange results and views to advance a transdisciplinary research agenda

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of their integrity. Centromeric ultrafine anaphase bridges are physiological DNA structures thought to contain unresolved DNA catenations between the centromeres separating during anaphase. BLM and PICH helicases colocalize at these ultrafine anaphase bridges and promote their resolution. As PICH is detectable at centromeres from prometaphase onwards, we hypothesized that BLM might also be located at centromeres and that the two proteins might cooperate to resolve DNA catenations before the onset of anaphase. Using immunofluorescence analyses, we demonstrated the recruitment of BLM to centromeres from G2 phase to mitosis. With a combination of fluorescence in situ hybridization, electron microscopy, RNA interference, chromosome spreads and chromatin immunoprecipitation, we showed that both BLM-deficient and PICH-deficient prometaphase cells displayed changes in centromere structure. These cells also had a higher frequency of centromeric non disjunction in the absence of cohesin, suggesting the persistence of catenations. Both proteins were required for the correct recruitment to the centromere of active topoisomerase IIα, an enzyme specialized in the catenation/decatenation process. These observations reveal the existence of a functional relationship between BLM, PICH and topoisomerase IIα in the centromere decatenation process. They indicate that the higher frequency of centromeric ultrafine anaphase bridges in BLM-deficient cells and in cells treated with topoisomerase IIα inhibitors is probably due not only to unresolved physiological ultrafine anaphase bridges, but also to newly formed ultrafine anaphase bridges. We suggest that BLM and PICH cooperate in rendering centromeric catenates accessible to topoisomerase IIα, thereby facilitating correct centromere disjunction and preventing the formation of supernumerary centromeric ultrafine anaphase bridges

In-hospital complications after invasive strategy for the management of Non STEMI: women fare as well as men

<p>Abstract</p> <p>Background</p> <p>To analyze the in-hospital complication rate in women suffering from non-ST elevation myocardial infarction treated with percutaneous coronary intervention (PCI) compared to men.</p> <p>Methods</p> <p>The files of 479 consecutive patients (133 women and 346 men) suffering from a Non STEMI (Non ST-segment elevation myocardial infarction) between the January 1^st2006 and March 21^st2009 were retrospectively analyzed with special attention to every single complication occurring during hospital stay. Data were analyzed using nonparametric tests and are reported as median unless otherwise specified. A p value < .05 was considered significant.</p> <p>Results</p> <p>As compared to men, women were significantly older (75.8 <it>vs</it>. 65.2 years; p < .005). All cardiovascular risk factors but tobacco and hypertension were similar between the groups: men were noticeably more often smoker (p < .0001) and women more hypertensive (p < .005). No difference was noticed for pre-hospital cardiovascular drug treatment. However women were slightly more severe at entry (more Killip class IV; p = .0023; higher GRACE score for in-hospital death - p = .008 and CRUSADE score for bleeding - p < .0001). All the patients underwent PCI of the infarct-related artery after 24 or 48 hrs post admission without sex-related difference either for timing of PCI or primary success rate. During hospitalization, 130 complications were recorded. Though the event rate was slightly higher in women (30% <it>vs</it>. 26% - p = NS), no single event was significantly gender related. The logistic regression identified age and CRP concentration as the only predictive variables in the whole group. After splitting for genders, these parameters were still predictive of events in men. In women however, CRP was the only one with a borderline p value.</p> <p>Conclusions</p> <p>Our study does not support any gender difference for in-hospital adverse events in patients treated invasively for an acute coronary syndrome without ST-segment elevation and elevated troponin.</p