The Two-Screen Measurement Setup to Indirectly Measure Proton Beam Self-Modulation in AWAKE

The goal of the first phase of the AWAKE \cite{AWAKE1,AWAKE2} experiment at CERN is to measure the self-modulation \cite{SMI} of the $\sigma_z = 12\,\rm{cm}$ long SPS proton bunch into microbunches after traversing $10\,\rm{m}$ of plasma with a plasma density of $n_{pe}=7\times10^{14}\,\rm{electrons/cm}^3$. The two screen measurement setup \cite{Turner2016} is a proton beam diagnostic that can indirectly prove the successful development of the self-modulation of the proton beam by imaging protons that got defocused by the transverse plasma wakefields after passing through the plasma, at two locations downstream the end of the plasma. This article describes the design and realization of the two screen measurement setup integrated in the AWAKE experiment. We discuss the performance and background response of the system based on measurements performed with an unmodulated Gaussian SPS proton bunch during the AWAKE beam commissioning in September and October 2016. We show that the system is fully commissioned and adapted to eventually image the full profile of a self-modulated SPS proton bunch in a single shot measurement during the first phase of the AWAKE experiment.Comment: 5 pages 8 figure

Indirect Self-Modulation Instability Measurement Concept for the AWAKE Proton Beam

AWAKE, the Advanced Proton-Driven Plasma Wakefield Acceleration Experiment, is a proof-of-principle R&D experiment at CERN using a 400 GeV/c proton beam from the CERN SPS (longitudinal beam size sigma_z = 12 cm) which will be sent into a 10 m long plasma section with a nominal density of approx. 7x10^14 atoms/cm3 (plasma wavelength lambda_p = 1.2mm). In this paper we show that by measuring the time integrated transverse profile of the proton bunch at two locations downstream of the AWAKE plasma, information about the occurrence of the self-modulation instability (SMI) can be inferred. In particular we show that measuring defocused protons with an angle of 1 mrad corresponds to having electric fields in the order of GV/m and fully developed self-modulation of the proton bunch. Additionally, by measuring the defocused beam edge of the self-modulated bunch, information about the growth rate of the instability can be extracted. If hosing instability occurs, it could be detected by measuring a non-uniform defocused beam shape with changing radius. Using a 1 mm thick Chromox scintillation screen for imaging of the self-modulated proton bunch, an edge resolution of 0.6 mm and hence a SMI saturation point resolution of 1.2 m can be achieved.Comment: 4 pages, 4 figures, EAAC conference proceeding

Novel parameter-based flexure bearing design method

A parameter study was carried out on the design variables of a flexure bearing to be used in a Stirling engine with a fixed axial displacement and a fixed outer diameter. A design method was developed in order to assist identification of the optimum bearing configuration. This was achieved through a parameter study of the bearing carried out with ANSYS®. The parameters varied were the number and the width of the arms, the thickness of the bearing, the eccentricity, the size of the starting and ending holes, and the turn angle of the spiral. Comparison was made between the different designs in terms of axial and radial stiffness, the natural frequency, and the maximum induced stresses. Moreover, the Finite Element Analysis (FEA) was compared to theoretical results for a given design. The results led to a graphical design method which assists the selection of flexure bearing geometrical parameters based on pre-determined geometric and material constraints

Particle physics applications of the AWAKE acceleration scheme

The AWAKE experiment had a very successful Run 1 (2016-8), demonstrating proton-driven plasma wakefield acceleration for the first time, through the observation of the modulation of a long proton bunch into micro-bunches and the acceleration of electrons up to 2 GeV in 10 m of plasma. The aims of AWAKE Run 2 (2021-4) are to have high-charge bunches of electrons accelerated to high energy, about 10 GeV, maintaining beam quality through the plasma and showing that the process is scalable. The AWAKE scheme is therefore a promising method to accelerate electrons to high energy over short distances and so develop a useable technology for particle physics experiments. Using proton bunches from the SPS, the acceleration of electron bunches up to about 50 GeV should be possible. Using the LHC proton bunches to drive wakefields could lead to multi-TeV electron bunches, e.g. with 3 TeV acceleration achieved in 4 km of plasma. This document outlines some of the applications of the AWAKE scheme to particle physics and shows that the AWAKE technology could lead to unique facilities and experiments that would otherwise not be possible. In particular, experiments are proposed to search for dark photons, measure strong field QED and investigate new physics in electron-proton collisions. The community is also invited to consider applications for electron beams up to the TeV scale.Comment: 12 pages, 8 figures, submitted to the European Particle Physics Strategy Update process. arXiv admin note: substantial text overlap with arXiv:1810.1225

Stroke genetics: prospects for personalized medicine.

Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke genes. The current findings are consistent with different stroke subtypes having different genetic architecture. These discoveries may identify novel pathways involved in stroke pathogenesis, and suggest new treatment approaches. However, the already identified genetic variants explain only a small proportion of overall stroke risk, and therefore are not currently useful in predicting risk for the individual patient. Such risk prediction may become a reality as identification of a greater number of stroke risk variants that explain the majority of genetic risk proceeds, and perhaps when information on rare variants, identified by whole-genome sequencing, is also incorporated into risk algorithms. Pharmacogenomics may offer the potential for earlier implementation of 'personalized genetic' medicine. Genetic variants affecting clopidogrel and warfarin metabolism may identify non-responders and reduce side-effects, but these approaches have not yet been widely adopted in clinical practice

High-gradient plasma and laser accelerators

Novel high-gradient accelerators have demonstrated acceleration of electrons and positrons with electric field strengths of 1 to > 100 GeV/m. This is about 10 to 1000 times higher than achieved in RF-based accelerators, and as such they have the potential to overcome the limitations associated with RF cavities. Plasma-based accelerators have produced multi-GeV bunches with parameters approaching those suitable for a linear collider. These accelerators offer the prospect of near term, compact and cost-effective particle physics experiments that provide new physics possibilities supporting precision studies and the search for new particles. The expert panel has defined a long term R&D roadmap towards a compact collider with attractive intermediate experiments and studies. A delivery plan for the required R&D has been developed and includes work packages, deliverables, a minimal plan, connections to ongoing projects and an aspirational plan

Differential effects of lung inflammation on insulin resistance in humans and mice

BACKGROUND: The rates of obesity, its associated diseases, and allergies are raising at alarming rates in most countries. House dust mites (HDM) are highly allergenic and exposure often associates with an urban sedentary indoor lifestyle, also resulting in obesity. The aim of this study was to investigate the epidemiological association and physiological impact of lung inflammation on obesity and glucose homeostasis. METHODS: Epidemiological data from 2207 adults of the population-based KORA FF4 cohort were used to test associations between asthma and rhinitis with metrics of body weight and insulin sensitivity. To obtain functional insights, C57BL/6J mice were intranasally sensitized and challenged with HDM and simultaneously fed with either low-fat or high-fat diet for 12 weeks followed by a detailed metabolic and biochemical phenotyping of the lung, liver, and adipose tissues. RESULTS: We found a direct association of asthma with insulin resistance but not body weight in humans. In mice, co-development of obesity and HDM-induced lung inflammation attenuated inflammation in lung and perigonadal fat, with little impact on body weight, but small shifts in the composition of gut microbiota. Exposure to HDM improved glucose tolerance, reduced hepatosteatosis, and increased energy expenditure and basal metabolic rate. These effects associate with increased activity of thermogenic adipose tissues independent of uncoupling protein 1. CONCLUSIONS: Asthma associates with insulin resistance in humans, but HDM challenge results in opposing effects on glucose homeostasis in mice due to increased energy expenditure, reduced adipose inflammation, and hepatosteatosis

Measurement and application of electron stripping of ultrarelativistic 208Pb81+^{208}\textrm{Pb}^{81+}

New measurements of the stripping cross-section for ultrarelativistic hydrogen-like lead ions passing through aluminium and silicon have been performed at the Advanced Wakefield experiment at CERN. Agreement with existing measurements and theory has been obtained. Improvements in terms of electron beam quality and ion beam diagnostic capability, as well as further applications of such an electron beam, are discussed

Biogenic weathering bridges the nutrient gap in pristine ecosystems - a global comparison

In many pristine ecosystems there seems to be negative nutrient budget existent, meaning that export exceeds the input received by aeolian deposition and physico-chemical weathering. Such ecosystems should degrade rather quickly, but are often found surprisingly stable on the long run. Our hypothesis was that this nutrient gap is an artefact caused by not considering the contribution of photoassimilatory-mediated biogenic weathering to the overall nutrient input, which might constitute an additional, energetically directed and demand driven pathway. Here, we firstly evaluated the evolution of mutualistic biogenic weathering along an Antarctic chronosequence and secondly compared the biogenic weathering rates under mycorrhized ecosystems over a global gradient of contrasting states of soil development. We found the ability to perform biogenic weathering increasing along its evolutionary development in photoautotroph-symbiont interaction and furthermore a close relation between fungal biogenic weathering and available potassium across all 16 forested sites in the study, regardless of the dominant mycorrhiza type (AM or EM), climate, and plant-species composition. Our results point towards a general alleviation of nutrient limitation at ecosystem scale via directional, energy driven and on-demand biogenic weathering

Für wen gebe ich mein Urteil ab? Der systematische Einfluss des Fragebogenadressaten auf Kausalattributionsgewichtungen bei geschlossenen Antwortformaten

Die Fragebogenforschung belegt, dass Respondenten durch Kontextinformationen eines Fragebogens systematisch in ihrem Antwortverhalten beeinflusst werden. So zeigten Norenzayan und Schwarz (1999), dass Probanden bei freier Antwortmöglichkeit eher persönlichkeitsbezogene Ursachen zur Erklärung von Straftaten nennen, wenn der Fragebogen scheinbar von einem Institut für Persönlichkeitsforschung (verglichen mit einem Institut für Sozialforschung) erstellt wurde. Hierzu diskutierte Erklärungen sind einerseits Konversationsmaximen, die einen Bezug zwischen Adressat und Gesagtem induzieren, andererseits kognitive Primings, die selektive kognitive Aktivierungen und damit Verfügbarkeiten bedingen sollen. Die vorliegende Studie untersucht diese Erklärungsalternativen, indem sie erstmals in einem analogen Studiendesign persönlichkeitsbezogene und soziale Gründe in geschlossenen Antwortformaten vorgibt und gewichten lässt. Mögliche Gewichtungsunterschiede sind somit nicht mittels kognitiver Verfügbarkeit erklärbar. Eine Kovarianzanalyse (Alter, Geschlecht und die Big-Five-Persönlichkeitsdimensionen als Kovariaten) belegt im Einklang mit den Konversationsmaximen eine signifikant stärkere Bedeutungszuschreibung für persönlichkeitsbezogene Ursachen unter der Bedingung „Institut für Persönlichkeitsforschung“ im Vergleich zu „Institut für Sozialforschung“ und einer Kontrollbedingung („Institut für Kriminologie“)