Normality of orbit closures for directing modules over tame algebras

AbstractWe show that the orbit closures for directing modules over tame algebras are normal and Cohen–Macaulay. The proof is based on degenerations to normal toric varieties

Normal forms of modules over admissible algebras with formal two-ray modules

The aim of the paper is to classify the indecomposable modules and describe the Auslander--Reiten sequences for admissible algebras with formal two-ray modules

The almost split triangles for perfect complexes over gentle algebras

AbstractThroughout the paper k denotes a fixed field. All vector spaces and linear maps are k-vector spaces and k-linear maps, respectively. By Z, N, and N+, we denote the sets of integers, nonnegative integers, and positive integers, respectively. For i,j∈Z, [i,j]:={l∈Z∣i≤l≤j} (in particular, [i,j]=∅ if i>j)

A characterization of admissible algebras with formal two-ray modules

In the paper we characterize, in terms of quivers and relations, the admissible algebras with formal two-ray modules introduced by G. Bobi\'nski and A. Skowro\'nski [Cent. Eur. J.Math.1 (2003), 457--476].Comment: Mainly correcting typos. Also a new abstract and minor changes in the introduction and subsection 3.

Does the patients age at cancer diagnosis affect microvessels density in uterine sarcoma tissues?

Objectives: The objective of the study was to retrospectively evaluate the density of vessels exhibiting positive glycoprotein CD34 expression in the uterine leiomyosarcoma tissues and their correlation with the age of patients at the time of tumor diagnosis. Material and methods: The archival paraffin blocks with the cancer tissues collected from 50 patients suffering from uterine leiomyosarcoma were used together with their clinical and demographic data. The immunohistochemical peroxidase-de­pendent methods were used to detect microvessels with positive CD34 expression. The glycoprotein CD34 expression was evaluated as a density of microvessel showing the positive immunohistochemical reaction (MVDCD34). Results: The negative, statistically significant correlation between the age of patients (at the moment diagnosis) and the MVDCD34+ (R = –0.289, p = 0.042) was found. Conclusions: The study’s findings may suggest that the tissues of younger people constitute a permissive environment for pro-angiogenic factors

Neuropilin 1 in uterine leiomyosarcoma. Clinical and pathological analysis

Objectives: The role of angiogenesis in leiomyosarcomas still remains unclear. The aim of this study was to evaluate the NRP1 expression in the leiomyosarcoma tissues and to find the relations between its expression and the clinical features. Material and methods: The study group consisted of 50 patients with diagnosis of the uterine leiomyosarcoma. Clinical and follow up data were collected. Using immunohistochemical methods the expression of NRP1 was detected. Results: The lack of NRP1 expression was found in 14 cases, positive (weak or moderate) expression was noted in 36 cases. The significantly higher expression of NRP1 was observed in more severe clinical stages in comparison to lower stages of the disease. The significantly shorter survival of patients with the positive expression of NRP1 in leiomyosarcoma was observed. Conclusions: The expression of NRP1 is associated with clinical advancement and worse prognosis in uterine LMS. Neuropilin 1 can be widely used as a postoperative survival predictor for the patients suffering from uterine LMS

Expression of caspase 9 and p53 in uterine leiomyosarcomas

Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis. Objectives: The aim of the study was to assess the expression of selected apoptosis proteins (caspase 9 and p53) using immunohistochemistry. Material and methods: A total of 28 tissue samples diagnosed in postoperative histopathological examination as leiomyosarcoma were tested. Twenty eight samples of leiomyomas were used as the control group. Colorful reactions with appropriate antibodies were performed to assess the expression of caspase 9 and p53. From every section 5 fields on view were chosen, in each one 100 cells were assessed using 400x magnification. T-Student parametric test and U Mann-Whitney test were used for statistical analysis. Results: Expression of caspase 9 was significantly lower (pMięsaki macicy są niejednorodną grupą nowotworow zarowno pod względem klinicznym jak i histologicznym. Proces onkogenezy związany z mutacją genow skutkuje nadmierną proliferacją oraz niekontrolowanym podziałem mitotycznym komórek poprzez blokowanie szlaków apoptozy. Kaspaza 9 oraz białko p53 odgrywają istotną rolę w procesie zaprogramowanej śmierci komórki. Cel pracy: Celem pracy była ocena immunohistochemiczna ekspresji kaspazy 9 oraz białka p53 w mięsakach macicy. Materiał i metody: Ocenie poddano 28 preparatów z rozpoznaniem histopatologicznym leiomyosarcoma uteri. Grupę kontrolną stanowiły tkanki mięśniaków macicy (n=28). Po wywołaniu reakcji barwnej przy użyciu przeciwciał przeciwko kaspazie 9 i p53, oceniano 100 komorek w polu widzenia o powiększeniu 400x, w obrębie 5 pol. Do analizy statystycznej wynikow zastosowano test parametryczny t-Studenta oraz U Manna-Whitneya. Wyniki: Ekspresja kaspazy 9 była istotnie statystycznie niższa (