13 research outputs found

    Дослідження синдрому емоційного і професійного вигорання у фармацетичних працівників

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    The burnout as a result of professional stress occurs when the adaptive capacity (resources) of the pharmaceutical worker in overcoming stressful situation becomes difficult, the "emotional burnout syndrome" - is the appropriate response to prolonged working stresses of employee during his professional activity. Our conducted researches in the regions of the country show that only 3-5% of pharmaceutical professionals familiar with the term "emotional burnout syndrome". So inKievto 10 per cent of people are familiar with this concept, at the same time, 54 per cent of workers aged 45-60 years old and 32 per cent aged 25-30 years old every day get into stressful situations and have different diseases, indicating the presence of the syndrome "professional burnout".Выгорание как следствие профессиональных стрессов возникает тогда, когда адаптационные возможности (ресурсы) фармацевтического работника в преодолении стрессовой ситуации становятся затруднительными, т.е. "синдром эмоционального выгорания" – это соответствующая реакция на продолжительные рабочие стрессы работника, в процессе его профессиональной деятельности. Проведенные собственные исследования в областях страны свидетельствуют, что только 3-5%  фармацевтических работников знакомы с понятием "синдром эмоционального выгорания". Так в  г. Киеве до 10% человек ознакомленным с этим понятием, в то же время 54% работников в возрасте 45-60 лет и 32% в возрасте 25-30 лет ежедневно попадают в стрессовые ситуации и имеют различные заболевания, свидетельствующие о наличии синдрома "профессионального выгорания".Вигорання як наслідок професійних стресів виникає тоді, коли адаптаційні можливості (ресурси) фармацевтичного працівника у подоланні стресової ситуації стають скрутними, тобто "синдром емоційного вигорання" - це відповідна реакція на тривалі робочі стреси працівника, в процесі його професійної діяльності. Проведені власні дослідження в регіонах країни свідчать, що тільки 3-5% фармацевтичних працівників знайомі з поняттям "синдром емоційного вигорання". Так у м. Києві до 10% осіб  ознайомлені з цим поняттям, в той же час 54% працівників у віці 45-60 років і 32% у віці 25-30 років щодня потрапляють в стресові ситуації і мають різні захворювання, що свідчать про наявність синдрому "професійного вигорання"

    Мелкоклеточный рак легкого. Цитологическая диагностика

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    The purpose of this article is to evaluate the possibilities of cytology for lung neuroendocrine tumors (small‑cell lung carcinoma and carcinoids) diagnostics. Cytology specimens obtained by bronchoscopy (n = 112), biopsy of metastatic lymph nodes (n = 27) or from pleural effusion (n = 8) were collected within over 1 year from 147 patients and studied. Small-cell lung carcinoma was diagnosed in 143 patients, representing 23,9 % of all lung carcinomas. The proportion of carcinoid tumors was 2,7 % of all neuroendocrine tumors. Typical carcinoid was observed in three cases, and atypical carcinoid — in one case. Cytologic features most significant for cytological diagnosis of small‑cell lung carcinoma and carcinoids were identified (n = 11). Discriminant analysis demonstrated that the proportion of accurate cytological diagnosis of small‑cell lung carcinoma and carcinoids was 96,69 %. Cytology is a reliable method for neuroendocrine tumor diagnosis. Immunocytochemistry with neuroendocrine markers along with light microscopy should be used to differentiate small‑cell lung carcinoma metastases from other tumors and non‑malignant pathology in pleural effusion specimens.Цель статьи — оценить возможности цитологической диагностики нейроэндокринных опухолей легкого: мелкоклеточного рака и карциноидов. Изучены данные цитологического обследования 147 пациентов в течение года, материал был получен при видеобронхоскопии (n = 112), верификации метастазов в лимфатических узлах (n = 27) и плевральном выпоте (n = 8). Мелкоклеточный рак легкого диагностирован у 143 пациентов, что составило 23,9 % от числа всех карцином легкого. Карциноидные опухоли от числа нейроэндокринных новообразований легких составили 2,7 %, в трех наблюдениях типичный и в одном — атипичный карциноид. Определены клеточные признаки, характерные для мелкоклеточного рака легкого и карциноидов, наиболее значимые при цитологической диагностике (n = 11). По данным дискриминантного анализа, частота точной цитологической диагностики мелкоклеточного рака легкого и типичного карциноида составляет 96,69 %. Цитологический метод диагностики нейроэндокринных опухолей является надежным методом. При дифференциальной диагностике метастазов мелкоклеточного рака легкого от других опухолей и неопухолевых процессов в плевральных выпотах, кроме световой микроскопии, показано использование иммуноцитохимических исследований с нейроэндокринными маркерами

    Evaluation of remote results of surgical treatment of nodular endemic goiter with autoimmune thyroiditis

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    Introduction. Autoimmune thyroiditis is one of the most important problems of modern endocrinology, with inadequately studied etiological and pathogenic mechanisms of development. It is characterized by the lack of objective and reliable diagnostic methods, effective treatment methods, uncertain therapy or indications for the choice of treatment methods. The aim of the study. Determination of markers for prediction of clinical course and choice of surgery’ volume in patients with nodular goiter and autoimmune thyroiditis, taking into account the oxidative, autoimmune and apoptotic processes. Material and methods. A total of 95 patients who were operated for a nodular endemic goiter on the background of autoimmune thyroiditis were examined. The status of pro- and antioxidant systems, the activity of proinflammatory cytokines, hormonal function of thyroid gland, the level of antibodies to thyroperoxidase, thyroglobulin antibodies and ultrasound structural changes in the thyroid gland have been evaluated in all patients, before and after surgery. Results. In patients with nodular endemic goiter and autoimmune thyroiditis, in the remote period after surgical treatment, there is a significant increase in the peroxide oxidation index and a decrease in the activity of antioxidant defense systems, against the suppression of apoptotic processes and the activation of pro-inflammatory cytokines. These processes lead to functional failure, hyperplasia and the progression of structural thyroid abnormalities, with progression of the functional incapacity of the thyroid gland and inadequate long-term outcome of treatment. Conclusions. The study allowed to clarify the indications and contraindications of different methods of treatment in patients with NGAIT, taking into account the parameters of severity of peroxide oxidation processes, the activity of apoptosis and functional capacity of the gland

    MODEL OF A DIPOLE WITH ATOMIC STRUCTURE

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    In this paper, we propose a model of a dipole with an atomic structure instead of the standard dipole model with point unlike charges and the Hertzian dipole model, which have significant drawbacks. The equations of the Hertzian dipole and the standard model operate from a distance much larger than size of the dipole, and the quasistatic Coulomb and Biot-Savart fields are the essence of the reactive near field, its own fields with a phase shift ΔφE,H = π/2, which have no restrictions on the distances to a dipole, since they are directly related to charges and their motion – currents. In the framework of the proposed dipole model, we described the physical mechanisms for the formation of near and far fields of an oscillating dipole, which are based on the use of the Coulomb and Biot-Savart fields, the quasistatic lines of force of their electric charge fields Е, and the magnetic fields of the currents Н for the analysis of energy fluxes: reactive Sr at ΔφE,H = π/2 and active Sа at ΔφE,H = 0 alike

    САМОСТІЙНА РОБОТА СТУДЕНТІВ ВИЩИХ МЕДИЧНИХ НАВЧАЛЬНИХ ЗАКЛАДІВ УКРАЇНИ, ЯК ОДИН З ЕТАПІВ ЇХ ПОДАЛЬШОЇ АДАПТАЦІЇ ДО РОБОТИ В ЛІКУВАЛЬНО-ПРОФІЛАКТИЧНИХ ЗАКЛАДАХ

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    Abstract. One of the main tasks of higher education is to provide basic professional fundamental knowledge and creative personality formation of specialist, training specialist capable of self-development, lifelong learning, creative thinking, open to innovative forms of activity. One important components of the educational process is self-study students. The article discusses the role of the teacher, the administration of medical institutions in the organization of independent work of students in higher educational institutions of Ukraine, proved its importance and feature in further adapting future professionals to work in health care facilities.Резюме. Одной из основных задач высшего образования является приобретение фундаментальных профессиональных знаний, а также формирование личности и воспитание специалиста, способного к саморазвитию, непрерывному самообразованию, креативному мышлению, открытого для инновационных форм деятельности. Одной из важных составляющих учебного процесса является самостоятельная работа студентов. В статье обсуждается роль преподавателя, администрации лечебных учреждений в организации самостоятельной работы студентов высших медицинских учебных заведений Украины, обоснована её важность и особенность в последующей адаптации будущих специалистов к работе в лечебно-профилактических учреждениях.Резюме. Одним з основних завдань вищої освіти є надання фундаментальних професійних знань та формування творчої особистості спеціаліста, виховання фахівця здатного до саморозвитку, безперервної самоосвіти, креативного мислення, відкритого до інноваційних форм діяльності. Однією з важливих складових навчального процесу є самостійна робота студентів. У статті обговорюється роль викладача, адміністрації лікувальних установ в організації самостійної роботи студентів вищих медичних навчальних закладів України, обґрунтована її важливість і особливість у подальшій адаптації майбутніх фахівців до роботи в лікувально-профілактичних установах

    Nonlinearity of Diffusion Resistors at High-density Current

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    The paper presents the results of an experimental study of the current dependence of the resistance of diffusion resistors (DR) produced by the "silicon with dielectric insulation" technology, with different geometric characteristics, in particular, length and thickness, with a current density of 105 A/cm2. The analysis of the obtained results is carried out and three areas on the dependence of resistance on current R(I) are determined. The first region is an ohmic plot, on which the resistance value of the diffusion resistor is linearly dependent on the current value. The second region of the curve R(I) is characterized by the presence of strong nonlinearity, jumps and a sharp increase in the resistance of the DR, which happen due to the emergence of a high electric field in the DR. The third region on R(I) is characterized by a decrease in the value of the current resistance: the thicker the DR, the lower the peak value of the resistance. It is shown that the change in the length and the decrease in the thickness of the diffusion resistors lead to a change in the length of the linear region on R(I): the smaller the length, the lower the resistance of the sample and the longer the area of stable differential resistance. The region of the linearity of the diffusion resistor is determined on the basis of the differential resistance on the current dependence. The linearity of the resistance was defined as the region where the change in the differential resistance did not exceed 10 % of its value at some small electric field: the largest region of the linearity of the resistor is present in a specimen with a length of 2.4 μm and a thickness of 8.4 μm. The revealed characteristics of the behavior of the resistance of the diffusion resistor are due to the change in its physical characteristics as a result of significant self-heating

    Hybrid electromagnetic-spin oscillations in the ferrite-dielectric structure with single-crystal hexaferrite in domain region

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    Hybrid electromagnetic-spin oscillations in ferrite-dielectric structure consisting of a single-crystal BaFe12O19 platelet and a dielectric disk-shaped resonator in multidomain state of ferrite have been investigated by experiment. Experiments were conducted with different types of domain structures, and the frequency-field spectra were measured at tangent magnetization. It was shown that the effective hybridization of electromagnetic and magnetostatic modes in such resonator could implement such excitation regime, where one electromagnetic mode of dielectric resonator is split into three hybrid quasi-electromagnetic oscillations even in the absence of external magnetizing fields

    Вибір хірургічної тактики у хворих з оклюзійно-стенотичним ураженням магістральних артерій головного мозку

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    An experience of 1246 patients treatment with brain magistral arteries stenosis and occlusion is presents. To 496 of them surgical treatment was performed with the use of open surgical and endovascular methods of revascularization. The necessary investigation volume and treatment tactic choice criteria were defined.Приведен опыт лечения 1246 больных с окклюзионно-стенотическим поражением магистральных артерий головного мозга, у 496 из них выполнено оперативное вмешательство с использованием как открытых хирургических способов реваскуляризации, так и эндоваскулярных. Определены объем необходимого обследования, критерии выбора тактики лечения больных.Наведений досвід лікування 1246 хворих з оклюзійно-стенотичним ураженням магістральних артерій головного мозку, у 496 з яких здійснене оперативне втручання з використанням як відкритих хірургічних способів реваскуляризації, так і ендоваскулярних. Визначені обсяг необхідного обстеження, критерії вибору тактики лікування хворих.

    Interaction of physical fields with nanostructured materials

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    Research results of several important material systems presented in this collective monograph demonstrate a number of characteristic features and unique effects. The main findings are listed below. 1. The interaction between molecules and semiconductor structures allows a new amplification effect to be registered and studied by utilizing a new parameter – characteristic time constant, which is extremely sensitive for the characterization of biomolecular quantity. 2. The effects of the interaction of magnetic, optical and electromagnetic fields with nanostructured composites, semiconductor structures, anisotropic media, magnetic fluid systems, layered structures, phonons of molecular nanocomplexes and nanoinhomogeneities of rough surfaces were established. 3. The fundamental nature of the interaction effects was found as a result of a careful comparison of modeling results with experimental data. The importance of the studies is underlined by the wide range of potential applications. For the reader’s convenience, the presentation of the material is structured as follows. The general content includes only the names of sections. The full content of each section is listed in the text. For the same reason, the list of references is given at the end of each section. The authors present the material in such a way that the reader can easily view the current state of research in these areas and be able to navigate freely in the text. Section 1 presents a number of effects registered in semiconductor structures with dielectric coatings as surface potential sensors. In particular, the effects of internal amplification in semiconductor (bio)sensors using single trap phenomena are revealed. The noise characteristics of semiconductor nanoscale sensor structures, the effect of γ-radiation on the noise and transport characteristics of the sensors mentioned above were analyzed. It is demonstrated that effects related to single traps can be used for the detection of troponin biomolecules as indicators of [...
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