IL-6 production in ovarian carcinoma is associated with histiotype and biological characteristics of the tumour and influences local immunity

The presence of interleukin (IL)-6 in peritoneal carcinomatous fluid (PCF) and its effect on immune cells composition in PCF in patients with advanced ovarian carcinoma was studied. In 21 out of 30 ovarian carcinoma patients, PCF IL-6 levels were found to exceed those seen in PCFs of patients with gastrointestinal cancer. IL-6 activity was higher in serous/mucinous than in endometrioid and undifferentiated ovarian carcinoma PCF (P = 0.05). Ovarian carcinoma PCF IL-6 activities were correlated with serum C-reactive protein levels (r = 0.65, P = 0.0000, n = 25). Ovarian carcinoma PCF leucocyte profile differed from that in blood with respect to: (i) lower percentage of NK and CD8+and (ii) higher percentage of B and CD45RO+, CD14+and HLA-DR+cells. The proportions of CD45RO+in blood were correlated with IL-6 levels in PCF. Corresponding to PCF ovarian carcinoma tumours were stained for the presence of Ki-67 antigen and p53. The highest proportions of Ki-67+cells and cells showing accumulation of p53 were seen in undifferentiated tumours. A low grade of p53 staining was seen in tumours associated with high IL-6 levels in PCF. It was evident that IL-6 production (i) depended on the histiotype of the tumour, (ii) influenced the local immune system in favour of accumulation of B, and T memory cells, and (iii) was higher in patients lacking p53 accumulation. © 2000 CancerResearch Campaig

Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma

The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4·2H2O, [VO(4,4′Me2bpy)2]SO4·2H2O, and Na[VO(O2)2(bpy)]·8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others

Characterisation of silicon strip detectors with a binary readout chip for X-ray imaging

In this paper we describe the development of a multichannel readout system for X-ray measurements using silicon strip detectors. The developed system is based on a binary readout architecture and optimised for detection of X-rays of energies in the range 6}30 keV. The critical component of the system is the 32-channel front-end chip, RX32N, which has been optimised for low noise performance, small channel to channel variation and high counting rate operation. The performance of the chip is demonstrated by measurements of complex X-ray spectra using silicon strip and pad detectors. The obtained results allow to use the system at room temperature with the detection threshold in the range from 500 to 10 000 electrons, which is enough in many crystallographic and medical imaging applications. ( 2000 Elsevier Scienc

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Tests of system for digital imaging with the X-ray of high intensity and selection of photon energy

W pracy przedstawiono budowę i wyniki testów zintegrowanego modułu do obrazowania cyfrowego umożliwiającego pracę z promieniowaniem X o dużym natężeniu i selekcje fotonów w zależności od ich energii. Elementem detekcyjnym modułu jest paskowy detektor krzemowy, z którego informacja jest odbierana i przetwarzana przez wielokanałowe specjalizowane układy scalone o architekturze binarnej. Uzyskane wyniki pomiarów 128 kanałowego modułu potwierdzają bardzo dobrą jednorodność poszczególnych kanałów, niski poziom szumów elektroniki odczytu oraz jej poprawną pracę również w przypadku bardzo dużej częstości impulsów wejściowych.The paper presents construction and tests of integrated module for digital X-ray imaging. This module could work with high X-ray intensity and selects photons according their energy. The module consists of silicon strip detector and ASICs of binary architecture. The measurement results of 128-channel module show its good noise parameters, uniformity of analogue parameters of multichannel ASIC and its possibility to work with high rate of input pulses

Data preparation for the purposes of 3D visualization

The article presents a method of preparing input data for 3D visualizations. The authors implemented the proposed procedure when they were working on a visualization, with use of Autodesk 3ds Max software. The test object were the ruins of a historic grange that belonged to the Nostitz family in Mściwojów (Mściwojów commune, Jaworski district, Lower-Silesia Voivodeship). After surveying the area and analyzing the data, using MicroStation with a geodetic application MK (Mapa Kontekstowa - context map), a Digital Terrain Model (DTM) was created along with contour lines, with use of Data Acquisition (a tool in some programs of Bentley). Next, the models of spatial objects were created using the authors' software VITAL LANDSCAPES Tools, developed during the EU CENTRAL EUROPE program. It was the basis for development of a visualization of current land management, using the sotware Autodesk 3ds Max. This allowed the design of the future land management of the historic grange so that the landscape balance is maintained. The data processed in this manner can be used for photorealistic visualizations in Autodesk 3ds Max or other graphical sotware

Characterisation of the UFXC32k hybrid pixel detector for time-resolved pump-probe diffraction experiments at Synchrotron SOLEIL

International audienceThe experimental set-up for time-resolved studies of ultra-fast photo-induced structural dynamics at the Synchrotron SOLEIL is based on a general pump-probe scheme that has been developed and implemented on the CRISTAL hard X-ray diffraction beamline [1,2]. In a so-called pump-probe cycle, the sample is excited with an ultra-short laser pulse of ≈40 fs duration (the pump), and induced changes in its atomic structure are studied by measuring, with a precisely controlled delay, a diffraction pattern from a single pulse of synchrotron radiation (the probe) with a 2-D pixel detector. An improvement to the classical scheme is proposed, where the sample's response is probed at two different delays after each laser excitation. The first measurement at short delays allows studying the photo-induced dynamics. The second one is a reference measurement taken after sample's relaxation, which permits detection of drifts in the experimental conditions (e.g. beam misalignment, sample degradation). A hybrid pixel detector with a very fast readout time, a high dynamic range and extended linearity was tested to achieve the experiment objectives. In this paper, the first results obtained with the UFXC32k single photon counting detector are presented

Prototype Silicon Position-Sensitive Detector Working with Bragg-Brentano Powder Diffractometer

A prototype 64-channel detector module, comprising a silicon strip detector with strip pitch of 100μm and 64-channel ASIC RX64, was tested with the X-Pert Philips MPD diffractometer. Basic parameters of the detector module, energy resolution, and detection efficiency, were evaluated as a function of the counting rate. Energy resolution of 1.1 keV FWHM for photon rate up to 1×10$\text{}^{7}$ photon/s per 1 cm of the active width of the detector was demonstrated. The prototype detector, when applied in a diffractometer utilizing Bragg-Brentano focusing principle, allows to increase the counting rate by about 2 orders of magnitude with respect to a single counter. Exemplary diffraction patterns of polycrystalline samples of Si and SiO$\text{}_{2}$ (quartz peak cluster) are presented