Beyond Tutoring: Mapping The Invisible Landscape of Writing Center Work

In their call for papers for this special issue of Praxis, the editors speculate that most writing centers assume various roles beyond those implied by the triage model of fix-it consultations. We agree. As the call suggests, writing centers have long sought to “carve out a broader purview” for themselves—to extend writing center efforts both beyond the center’s physical space and beyond enduring writing center master narratives about the primacy of individual instruction. Still, much of the writing center’s extra curriculum, or what we call here non-tutoring work, remains hidden: for example, writing center scholarship provides anecdotal evidence of writing centers’ work with faculty, but the scholarship rarely tells us just how prevalent such efforts are across the board or what other kinds of non-tutoring work we are engaged in. To borrow from the field of landscape architecture, what our field lacks is an aerial—and ultimately generative—vision of our non-tutoring activities, one that would “reveal aspects of the landscape that are invisible from the ground and offer an alternative to pictorial [read “local”] practices so common in landscape representation” (Czerniak 111). There are consequences to invisibility. We cannot theorize what we cannot see, although theories are always already there, shaping our identities and practices in ways that might or might not be acceptable to us if only we could see and name their contours. Viewing the writing center landscape from a different vantage point, then, gives us much more than an updated map: it challenges us to re-theorize who we are and what makes our work valuable.University Writing Cente

Ready to Launch?: Preparing Tutors for Next Steps

The central question of this panel is: What responsibility do writing center administrators have for preparing tutors for their post-writing center careers and lives and what would such preparation look like? In recent years, writing center scholarship has touched on this issue (see Welsch 2008; Whalen 2009; Dinitz & Kiedaisch, 2009; Hughes, et al. 2010); this panel is extension of this scholarship by different administrators at three different universities. Our panel discusses the difficulties and successes we’ve had in shaping and in assessing professional/career development for our staffs based on the models and suggestions in the writing center literature

Can changes in health related quality of life scores predict survival in stages III and IV colorectal cancer?

<p>Abstract</p> <p>Background</p> <p>Several studies have demonstrated the predictive significance on survival of baseline quality of life (QoL) in colorectal cancer (CRC) with little information on the impact of changes in QoL scores on prognosis in CRC. We investigated whether changes in QoL during treatment could predict survival in CRC.</p> <p>Methods</p> <p>We evaluated 396 stages III-IV CRC patients available for a minimum follow-up of 3 months. QoL was evaluated at baseline and after 3 months of treatment using EORTC QLQ-C30. Cox regression evaluated the prognostic significance of baseline, 3-month and changes in QoL scores after adjusting for age, gender and stage at diagnosis.</p> <p>Results</p> <p>After adjusting for covariates, every 10-point increase in both baseline appetite loss and global QoL score was associated with a 7% increased risk of death with HR = 1.07 (95% CI, 1.01-1.14; <it>P </it>= 0.02) and (HR = 0.93 (95% CI, 0.87-0.98; <it>P </it>= 0.01) respectively. A lower risk of death was associated with a 10-point improvement in physical function at 3 months (HR, 0.86; 95% CI, 0.78-0.94; <it>P </it>= 0.001). Surprisingly, a higher risk of death was associated with a 10-point improvement in social function at 3 months (HR, 1.08; 95% CI, 1.02-1.13; <it>P </it>= 0.008).</p> <p>Conclusions</p> <p>This study provides preliminary evidence to indicate that CRC patients whose physical function improves within 3 months of treatment have a significantly increased probability of survival. These findings should be used in clinical practice to systematically address QoL-related problems of CRC patients throughout their treatment course.</p

Dose escalation study of an anti-thrombocytopenic agent in patients with chemotherapy induced thrombocytopenia

<p>Abstract</p> <p>Background</p> <p>Preclinical studies demonstrated that small chain RNA fragments accelerate the recovery of platelets numbers in animals exposed to high doses of chemotherapeutic drugs. There is anecdotal data supporting the same application in humans. The Phase I clinical trial described here was designed to investigate the relationship between the administration of small chain RNA fragments and the recovery in platelets following Chemotherapy-Induced Thrombocytopenia (CIT).</p> <p>Methods</p> <p>Cancer patients with solid tumors that experienced post chemotherapy thrombocytopenia with a nadir of < = 80,000 platelets/ml were eligible for this clinical trial. There were no exclusions based on ECOG status, tumor type, tumor burden or chemotherapeutic agents. Patients received a unique preparation of RNA derived from either E. coli or yeast. Ten patients per group received 20, 40, or 60 mg as a starting dose. Subjects self-administered RNA fragments sublingually on an every other day schedule while undergoing chemotherapy. The dose was escalated in 20 mg increments to a maximum dose of 80 mg if the nadir was < 80,000 platelets/ml at the start of the next cycle. Subjects were treated for three cycles of chemotherapy with the maximum effective dose of RNA fragments. Subjects continued on planned chemotherapy as indicated by tumor burden without RNA fragment support after the third cycle. Subjects kept a diary indicating RNA fragment and magnesium administration, and any experienced side effects.</p> <p>Results</p> <p>Patients receiving E. coli RNA fragments demonstrated a more rapid recovery in platelet count and higher nadir platelet count. None of the patients receiving the E. coli RNA fragments required a chemotherapy dose reduction due to thrombocytopenia. The optimal dose for minimizing CIT was 80 mg. Conversely, subjects receiving yeast RNA fragments with dose escalation to 80 mg required a chemotherapy dose reduction per American Society of Clinical Oncology guidelines for grade 3 and 4 thrombocytopenia.</p> <p>Conclusions</p> <p>Patients receiving myelosuppressive chemotherapy experienced an improvement in the platelet nadir and shorter recovery time when receiving concurrent E coli RNA fragments, when compared to patients who received yeast RNA fragments. These data indicate that 60 and 80 mg doses of E. coli RNA accelerated platelet recovery. Further clinical investigations are planned to quantify the clinical benefits of the E. coli RNA at the 80 mg dose in patients with chemotherapy induced thrombocytopenia.</p> <p>Trial Registration</p> <p>Clinical Trials.gov Identifier: NCT01163110</p

Information Integration in a Mining Landscape

The integration of information sources is a fundamental step to advance research and knowledge about the ancient mining landscape of Schwaz/Brixlegg in the Tyrol / Austria. The approach is applied for the localization, identification and interpretation of mining structures within the area. We want to show the use of the CIDOC CRM ontology with extensions in combination with a thesaurus to integrate data on a conceptual level. To implement this integration, we applied semantic web technologies to create a knowledge graph in RDF (Resource Description Framework) that currently represents the available information of seven different information sources in a network structure. More sources will be integrated using the same methodology. These are geochemical analysis of artefacts, onomastic research on names related to mining and archaeological information of other mining areas to research the spread of prehistoric mining activities and technologies. The RDF network can be queried for research, cultural or emergency response questions and the results can be displayed using Geoinformation systems. An exemplary archaeological research question is the location of mining, settlement and burial sites in the Bronze Age, differentiating between ore extraction, ore processing and smelting activities. For emergency forces the names and exact locations of mines are essential in case of an accident within an old mine. Different questions require a subset of the created knowledge graph. The results of queries to retrieve specific information can be visualised using appropriate tools

Mining at the Fringes. High-Altitude Prehistoric Copper Mining in the Oberhalbstein Valley (Grisons, Switzerland)

The mining region of Oberhalbstein, to date sparsely studied, has been the subject of archaeological research since 2013. Two mining areas which lie well above the forest line were studied in the summer of 2017. The Avagna-Ochsenalp site includes multi-phased heap features, of which the earliest phase has been dendrochronologically dated to the 11th century BC. In Cotschens, mining traces in an area of approximately 0.1 km2 from an unknown time period have been observed. Here, the flooded mine 1 was studied in more detail. After the cavity had been drained, 66 wood objects were revealed, including mining tools from the 1st century BC. 14C dating further confirms Late Bronze Age and Early to Late Iron Age activity. Stone tools from the adjacent heap also confirm prehistoric on-site ore processing, a unique find so far in the Oberhalbstein region

Montanlandschaft Oberhalbstein – prähistorische Kupferproduktion in Graubünden

Seit Jahrzehnten als prähistorisches Bergbaugebiet bekannt, war das Oberhalbstein in den vergangenen Jahren erstmals Gegenstand systematischer montanarchäologischer Forschungen. Dabei wurden nicht nur Dutzende neue Fundstellen entdeckt, sondern erstmals auch zentrale Verhüttungsbefunde wie Öfen und Röstbette ausgegraben. Zudem konnten gleich mehrere Kupferbergwerke aus der Bronze- und Eisenzeit untersucht werden – eine schweizweite Premiere! Dank ausführlicher Geländearbeiten, Materialauswertungen und Laboranalysen kann nun der gesamte «Oberhalbstein-Prozess» vom Erz bis zum Metall rekonstruiert werden

Cross-correlated relaxation measurements under adiabatic sweeps: determination of local order in proteins

Adiabatically swept pulses were originally designed for the purpose of broadband spin inversion. Later, unexpected advantages of their utilization were also found in other applications, such as refocusing to excite spin echoes, studies of chemical exchange or fragment-based drug design. Here, we present new experiments to characterize fast (ps-ns) protein dynamics, which benefit from little-known properties of adiabatic pulses. We developed a strategy for measuring cross-correlated cross-relaxation (CCCR) rates during adiabatic pulses. This experiment provides a linear combination of longitudinal and transverse CCCR rates, which is offset-independent across a typical amide spectrum. The pulse sequence can be recast to provide accurate transverse CCCR rates weighted by the populations of exchanging states. Sensitivity can be improved in systems in slow exchange. Finally, the experiments can be easily modified to yield residue-specific correlation times. The average correlation time of motions can be determined with a single experiment while at least two different experiments had to be recorded until now