New Outlook on the Possible Existence of Superheavy Elements in Nature

A consistent interpretation is given to some previously unexplained phenomena seen in nature in terms of the recently discovered long-lived high spin super- and hyper-deformed isomeric states. The Po halos seen in mica are interpreted as due to the existence of such isomeric states in corresponding Po or nearby nuclei which eventually decay by gamma- or beta-decay to the ground states of 210Po, 214Po and 218Po nuclei. The low-energy 4.5 MeV alpha-particle group observed in several minerals is interpreted as due to a very enhanced alpha transition from the third minimum of the potential-energy surface in a superheavy nucleus with atomic number Z=108 (Hs) and atomic mass number around 271 to the corresponding minimum in the daughter.Comment: 8 pages, 8 figures, 5 tables. Paper presented at VII Int. School-Seminar on Heavy Ion Physics, May 27 - June 1, 2002, Dubna, Russi

Mashups: An Approach to Overcoming the Business/IT Gap in Service-Oriented Architectures

For quite a long time already, great importance has been attached to the concept of Service-Oriented Architectures for future IT-architectures. However, a major challenge in implementing this concept lies in the gap between the functional department and IT department. Mashups, an architecture also based on services, try to avoid this gap by letting the user himself integrate the services. The following article analyzes similarities and differences between both architecture approaches, and explains to what extent and in which cases Mashups could complement a Service-Oriented Architecture

Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus

BACKGROUND. Persistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied. METHODS. Serum samples from 15 persistent carriers and 19 noncarriers were analyzed for immunoglobulin (Ig) G, IgA, and IgM binding to 19 S. aureus antigens, by means of Luminex technology. Nasal secretions and serum samples obtained after 6 months were also analyzed. RESULTS. Median serum IgG levels were significantly higher in persistent carriers than in noncarriers for toxic shock syndrome toxin (TSST)-1 (median fluorescence intensity [MFI] value, 11,554 vs. 4291; P < .001) and staphylococcal enterotoxin (SE) A (742 vs. 218; P < .05); median IgA levels were higher for TSST-1 (P < .01), SEA, and clumping factor (Clf) A and B (P < .05). The in vitro neutralizing capacity of anti-TSST-1 antibodies was correlated with the MFI value (R(2) = 0.93) and was higher in persistent carriers (90.6% vs. 70.6%; P < .05). Antibody levels were stable over time and correlated with levels in nasal secretions (for IgG, R(2) = 0.87; for IgA, R(2) = 0.77). CONCLUSIONS. Antibodies to TSST-1 ha

Synergism between particle-based multiplexing and microfluidics technologies may bring diagnostics closer to the patient

In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick high-throughput assays. On the one hand, recent progress in microfluidics technologies is expected to strongly support the development of miniaturized analytical devices, which will speed up (bio)analytical assays. On the other hand, a higher throughput can be obtained by the simultaneous screening of one sample for multiple targets (multiplexing) by means of encoded particle-based assays. Multiplexing at the macro level is now common in research labs and is expected to become part of clinical diagnostics. This review aims to debate on the “added value” we can expect from (bio)analysis with particles in microfluidic devices. Technologies to (a) decode, (b) analyze, and (c) manipulate the particles are described. Special emphasis is placed on the challenges of integrating currently existing detection platforms for encoded microparticles into microdevices and on promising microtechnologies that could be used to down-scale the detection units in order to obtain compact miniaturized particle-based multiplexing platforms

Pharmacokinetics and subjective effects of 1P-LSD in humans after oral and intravenous administration

1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous self-administrations of 100 µg 1P LSD hemitartrate are reported in two human volunteers followed by analyses of urine and serum samples using a fully validated LC MS/MS method. Psychometric evaluations included assessment of selected subjective drug effects and administration of the Five-Dimensions of Altered States of Consciousness rating scale (5D ASC). In serum and urine, oral administrations of 1P-LSD only led to the detection of LSD reflecting biphasic elimination with a terminal elimination half-life of approx. t1/2=6.4 h. 1P LSD could be detected for only up to 4.16 h in serum and 2.7 h in urine following intravenous administration whereas LSD was detected in all serum samples (last sampling after approx. 24 h) and up to 80 h in urine. LSD showed first order elimination kinetics with an approx. t1/2=5.7 h, whereas 1P LSD showed a rapid decrease in concentration within the first hour followed by a slower decrease, most probably due to hydrolysis. Bioavailability of LSD after oral ingestion of 1P LSD was close to 100%. The psychosensory effects of 1P LSD and their time course were comparable to those seen after uptake of LSD in other studies which further supports the prodrug hypothesis. The 5D ASC scores were higher after oral compared with intravenous administration of 1P LSD