4,487 research outputs found
Beyond the Jaynes-Cummings model: circuit QED in the ultrastrong coupling regime
In cavity quantum electrodynamics (QED), light-matter interaction is probed
at its most fundamental level, where individual atoms are coupled to single
photons stored in three-dimensional cavities. This unique possibility to
experimentally explore the foundations of quantum physics has greatly evolved
with the advent of circuit QED, where on-chip superconducting qubits and
oscillators play the roles of two-level atoms and cavities, respectively. In
the strong coupling limit, atom and cavity can exchange a photon frequently
before coherence is lost. This important regime has been reached both in cavity
and circuit QED, but the design flexibility and engineering potential of the
latter allowed for increasing the ratio between the atom-cavity coupling rate
and the cavity transition frequency above the percent level. While these
experiments are well described by the renowned Jaynes-Cummings model, novel
physics is expected in the ultrastrong coupling limit. Here, we report on the
first experimental realization of a superconducting circuit QED system in the
ultrastrong coupling limit and present direct evidence for the breakdown of the
Jaynes-Cummings model.Comment: 5 pages, 3 figure
A rare association of crossed fused renal ectopia
BACKGROUND: Thrombocytopenia and absent radius syndrome (TAR) is a rare genetic disorder. It is an autosomal recessive disorder characterised by radial aplasia and thrombocytopenia that may have additional anomalies. We report a case of TAR syndrome with crossed fused renal ectopia. This anomaly has not been previously reported in association with TAR syndrome. CASE PRESENTATION: A 24 years old female with Thrombocytopenia and absent radius syndrome admitted with pelvic fracture was investigated for recurrent urinary tract infections. Abdominal ultrasonography could not visualise the kidney on right side. Further extensive investigations in the form of intravenous urography (IVU), Magnetic resonance imaging (MRI) and renal isotope scans revealed a crossed fused renal ectopia. CONCLUSION: This report describes the new finding of a crossed fused renal ectopia associated with TAR syndrome that has not been reported before in the literature. Ectopic kidneys have increased susceptibility to develop complications like urinary infections, urolithiasis, and abdominal mass. There is a reported case of TAR syndrome with renal anomaly that developed Wilm's tumor. Finding of crossed fused renal ectopia warrants complete urologic investigation to rule out surgically correctable pathology in the urinary tract
Ownership-dependent mating tactics of minor males of the beetle Librodor japonicus (Nitidulidae) with intra-sexual dimorphism of mandibles
Intra-sexual dimorphism is found in the weapons of many male beetles. Different behavioral tactics to access females between major and minor males, which adopt fighting and alternative tactics, respectively, are thought to maintain the male dimorphism. In these species major males have enlarged weapons that they use in fights with rival males. Minor males also have small weapons in some of these species, and it is unclear why these males possess weapons. We examined the hypothesis that minor males might adopt a fighting tactic when their status was relatively high in comparison with that of other males (e.g., ownership of a territory). We observed the behavioral tactics of major and minor males of the beetle Librodor japonicus, whose males have a dimorphism of their mandibles. Major males fought for resources, whereas minor males adopted two status-dependent tactics, fighting and sneaking, to access females, depending on their ownership of a sap site. We suggest that ownership status-dependent mating tactics in minor males may maintain the intra-sexual dimorphism in this beetle.</p
Sub-Planckian black holes and the Generalized Uncertainty Principle
The Black Hole Uncertainty Principle correspondence suggests that there could
exist black holes with mass beneath the Planck scale but radius of order the
Compton scale rather than Schwarzschild scale. We present a modified, self-dual
Schwarzschild-like metric that reproduces desirable aspects of a variety of
disparate models in the sub-Planckian limit, while remaining Schwarzschild in
the large mass limit. The self-dual nature of this solution under naturally implies a Generalized Uncertainty Principle
with the linear form . We also
demonstrate a natural dimensional reduction feature, in that the gravitational
radius and thermodynamics of sub-Planckian objects resemble that of -D
gravity. The temperature of sub-Planckian black holes scales as rather than
but the evaporation of those smaller than g is suppressed by
the cosmic background radiation. This suggests that relics of this mass could
provide the dark matter.Comment: 12 pages, 9 figures, version published in J. High En. Phy
Renormalization group approach to matrix models via noncommutative space
We develop a new renormalization group approach to the large-N limit of
matrix models. It has been proposed that a procedure, in which a matrix model
of size (N-1) \times (N-1) is obtained by integrating out one row and column of
an N \times N matrix model, can be regarded as a renormalization group and that
its fixed point reveals critical behavior in the large-N limit. We instead
utilize the fuzzy sphere structure based on which we construct a new map
(renormalization group) from N \times N matrix model to that of rank N-1. Our
renormalization group has great advantage of being a nice analog of the
standard renormalization group in field theory. It is naturally endowed with
the concept of high/low energy, and consequently it is in a sense local and
admits derivative expansions in the space of matrices. In construction we also
find that our renormalization in general generates multi-trace operators, and
that nonplanar diagrams yield a nonlocal operation on a matrix, whose action is
to transport the matrix to the antipode on the sphere. Furthermore the
noncommutativity of the fuzzy sphere is renormalized in our formalism. We then
analyze our renormalization group equation, and Gaussian and nontrivial fixed
points are found. We further clarify how to read off scaling dimensions from
our renormalization group equation. Finally the critical exponent of the model
of two-dimensional gravity based on our formalism is examined.Comment: 1+42 pages, 4 figure
IFNγ production in peripheral blood of early Lyme disease patients to hLFAα(L) (aa326-345)
BACKGROUND: It has been proposed that outer surface protein A (OspA) of Borrelia burgdorferi sensu stricto contains a T helper 1 (Th1) cell epitope that could play a role in an autoimmune response to hLFA1. METHODS: We used two peptides, hLFAα(L) (aa326-345) and Borrelia burgdorferi OspAB31 (aa164-183), as stimulating antigens to measure Th1 proinflammatory IFNγ cytokine production in peripheral blood of Lyme disease patients presenting with EM without history of arthritis, as well as in peripheral blood of healthy individuals. RESULTS: IFNγ responses to hLFA1 peptide were observed in 11 of 19 Lyme disease patients and in 3 of 15 healthy controls. In contrast, only 2 of 19 of the Lyme disease patients and none of the controls responded to the homologous OspAB31 peptide. CONCLUSIONS: IFNγ was produced in response to stimulation with peptide hLFAα(L) (aa326-345) in peripheral blood of 58% of patients with early Lyme disease without signs of arthritis, as well as in peripheral blood of 20% of healthy individuals, but not in response to stimulation with the homologous OspAB31 (aa164-183) peptide (p < 0.05). Our results suggest that reactivity to the hLFA1 peptide in peripheral blood may be the result of T cell degeneracy
Measurement of the charm structure function F_{2,c)^{γ} of the photon at LEP
The production of charm quarks is studied in deep-inelastic electron–photon scattering using data recorded by the OPAL detector at LEP at nominal e⁺e⁻ centre-of-mass energies from 183 to 209 GeV. The charm quarks have been identified by full reconstruction of charged D* mesons using their decays into D⁰π with the D⁰ observed in two decay modes with charged particle final states, Kπ and Kπππ. The cross-section σ^{D*} for production of charged D* in the reaction e⁺e⁻→e⁺e⁻D*Χ is measured in a restricted kinematical region using two bins in Bjorken x, 0.00140.1 the perturbative QCD calculation at next-to-leading order agrees perfectly with the measured cross-section. For x<0.1 the measured cross-section is 43.8±14.3±6.3±2.8 pb with a next-to-leading order prediction of 17.0⁺²·⁹_₂.₃ pb
On the Action of Methotrexate and 6-Mercaptopurine on M. avium Subspecies paratuberculosis
BACKGROUND: Clinical improvement in inflammatory bowel disease (IBD) treated with methotrexate and 6-mercaptopurine (6-MP) is associated with a decrease in pro-inflammatory cytokines. This has been presumed to indicate the mechanism of action of methotrexate and 6-MP. Although controversial, there are increasingly compelling data that Mycobacterium avium subspecies paratuberculosis (MAP) may be an etiological agent in some or all of IBD. We hypothesized that the clinical efficacy of methotrexate and 6-MP in IBD may be to simply inhibit the growth of MAP. METHODOLOGY: The effect on MAP growth kinetics by methotrexate and 6-MP were evaluated in cell culture of two strains each of MAP and M. avium using a radiometric ((14)CO(2) BACTEC®) detection system that quantifies mycobacterial growth as arbitrary “growth index units” (GI). Efficacy data are presented as “percent decrease in cumulative GI” (% −ΔcGI). PRINCIPAL FINDINGS: The positive control antibiotic (clarithromycin) has ≥85% −ΔcGI at a concentration of 0.5 µg/ml. The negative control (ampicillin) has minimal inhibition at 64 µg/ml. MAP ATCC 19698 shows ≥80% −ΔcGI for both agents by 4 µg/ml. With the other three isolates, although more effective than ampicillin, 6-MP is consistently less effective than methotrexate. CONCLUSIONS: We show that methotrexate and 6-MP inhibit MAP growth in vitro. Each of the four isolates manifests different % −ΔcGI. These data are compatible with the hypothesis that the clinical improvement in patients with IBD treated with methotrexate and 6-MP could be due to treating a MAP infection. The decrease in pro-inflammatory cytokines, thought to be the primary mechanism of action, may simply be a normal, secondary, physiological response. We conclude that henceforth, in clinical studies that evaluate the effect of anti-MAP agents in IBD, the use of methotrexate and 6-MP should be excluded from any control groups
Can sacrificial feeding areas protect aquatic plants from herbivore grazing? Using behavioural ecology to inform wildlife management
Effective wildlife management is needed for conservation, economic and human well-being objectives. However, traditional population control methods are frequently ineffective, unpopular with stakeholders, may affect non-target species, and can be both expensive and impractical to implement. New methods which address these issues and offer effective wildlife management are required. We used an individual-based model to predict the efficacy of a sacrificial feeding area in preventing grazing damage by mute swans (Cygnus olor) to adjacent river vegetation of high conservation and economic value. The accuracy of model predictions was assessed by a comparison with observed field data, whilst prediction robustness was evaluated using a sensitivity analysis. We used repeated simulations to evaluate how the efficacy of the sacrificial feeding area was regulated by (i) food quantity, (ii) food quality, and (iii) the functional response of the forager. Our model gave accurate predictions of aquatic plant biomass, carrying capacity, swan mortality, swan foraging effort, and river use. Our model predicted that increased sacrificial feeding area food quantity and quality would prevent the depletion of aquatic plant biomass by swans. When the functional response for vegetation in the sacrificial feeding area was increased, the food quantity and quality in the sacrificial feeding area required to protect adjacent aquatic plants were reduced. Our study demonstrates how the insights of behavioural ecology can be used to inform wildlife management. The principles that underpin our model predictions are likely to be valid across a range of different resource-consumer interactions, emphasising the generality of our approach to the evaluation of strategies for resolving wildlife management problems
High Energy Bounds on Soft N=4 SYM Amplitudes from AdS/CFT
Using the AdS/CFT correspondence, we study the high-energy behavior of
colorless dipole elastic scattering amplitudes in N=4 SYM gauge theory through
the Wilson loop correlator formalism and Euclidean to Minkowskian analytic
continuation. The purely elastic behavior obtained at large impact-parameter L,
through duality from disconnected AdS_5 minimal surfaces beyond the
Gross-Ooguri transition point, is combined with unitarity and analyticity
constraints in the central region. In this way we obtain an absolute bound on
the high-energy behavior of the forward scattering amplitude due to the
graviton interaction between minimal surfaces in the bulk. The dominant
"Pomeron" intercept is bounded by alpha less than or equal to 11/7 using the
AdS/CFT constraint of a weak gravitational field in the bulk. Assuming the
elastic eikonal approximation in a larger impact-parameter range gives alpha
between 4/3 and 11/7. The actual intercept becomes 4/3 if one assumes the
elastic eikonal approximation within its maximally allowed range L larger than
exp{Y/3}, where Y is the total rapidity. Subleading AdS/CFT contributions at
large impact-parameter due to the other d=10 supergravity fields are obtained.
A divergence in the real part of the tachyonic KK scalar is cured by
analyticity but signals the need for a theoretical completion of the AdS/CFT
scheme.Comment: 25 pages, 3 eps figure
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