Effect of phenoxybenzamine on cardiovascular and plasma catecholamine responses to clonidine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109911/1/cptclpt198324.pd

FAPT: a Mathematica package for calculations in QCD Fractional Analytic Perturbation Theory

We provide here all the procedures in \texttt{Mathematica} which are needed for the computation of the analytic images of the strong coupling constant powers in Minkowski (${\bar{\mathfrak A}_{\nu}(s;n_f)}$ and ${\mathfrak A_{\nu}^\text{glob}(s)}$) and Euclidean (${\bar{\mathcal A}_{\nu}(Q^2;n_f)}$ and ${\mathcal A_{\nu}^\text{glob}(Q^2)}$) domains at arbitrary energy scales (${s}$ and ${Q^2}$, correspondingly) for both schemes --- with fixed number of active flavours ${n_f=3, 4, 5, 6}$ and the global one with taking into account all heavy-quark thresholds. These singularity-free couplings are inevitable elements of Analytic Perturbation Theory (APT) in QCD and its generalization --- Fractional APT, needed to apply the APT imperative for renormalization-group improved hadronic observables.Comment: 23 pages, 6 figures. Citations added. Now it matches version approved for publication in Comp. Phys. Commu

Uso de sulfato de magnésio em pacientes com asma aguda grave em sala de emergência pediátrica

Introdução: A asma é uma doença crônica e de alta prevalência com importante morbimortalidade. O uso do sulfato de magnésio endovenoso contínuo está indicado aos casos refratários ao manejo inicial em sala de emergência pediátrica. Objetivo: Analisar o uso de sulfato de magnésio em crianças com asma aguda grave que internaram em sala de emergência. Métodos: Estudo de coorte prospectiva. Foram analisados todos os pacientes que receberam sulfato de magnésio endovenoso contínuo em 4 horas a uma dose de 50mg/kg/h para tratamento de crise de asma aguda grave refratária ao manejo inicial, no período de 2017 a 2019. Foi observado resposta clínica, nível sérico de magnésio e eventos adversos. Resultados: Dos 40 pacientes que preencheram os critérios de elegibilidade, 60% foram do sexo masculino e 40% do sexo feminino, com uma mediana de idade de 3 anos. Não houve descrição de eventos adversos durante e após a administração do sulfato de magnésio. Comparando o escore clínico de Wood-Downes modificado antes da administração do sulfato de magnésio (variação de 3-6) e após o fim da infusão do sulfato de magnésio (variação de 5-0) foi observada melhora clínica significativa (p<0,001). Os níveis séricos de magnésio obtidos ao final da infusão variaram de 3,3-5,6 mg/dL, adequados como terapêuticos. A mediana do tempo de internação em emergência pediátrica foi de 2 dias. Não houve óbitos e nenhum dos pacientes necessitou ventilação mecânica. Conclusões: Com base nesse estudo, a utilização do sulfato de magnésio endovenoso contínuo (dose 50 mg/kg/h em 4 horas) mostrou-se segura e pode ser uma terapia adjuvante satisfatória no manejo da asma grave após falha inicial.Introduction: Asthma is a chronic and highly prevalent disease with significant morbidity and mortality. The use of continuous intravenous magnesium sulfate is indicated for cases refractory to initial management in a pediatric emergency room. Objective: To analyze the use of magnesium sulfate in children with acute severe asthma who were admitted to the emergency room. Methods: This is a prospective cohort study. All patients who received continuous intravenous magnesium sulfate during 4 hours at a dose of 50mg/kg/h were analyzed for the treatment of severe acute asthma attacks refractory to the initial management, from 2017 to 2019. Clinical response, serum magnesium level and adverse events were observed. Results: Of the 40 patients who met the eligibility criteria, 60% were male and 40% female, with a median age of 3 years. There was no description of adverse events during and after the administration of magnesium sulfate. Comparing the modified Wood-Downes clinical score before magnesium sulfate administration (range 3-6) and after the end of magnesium sulfate infusion (range 5-0), significant clinical improvement was observed (p<0.001). The serum magnesium levels obtained at the end of the infusion ranged from 3.3 to 5.6 mg/dL, which are suitable as therapeutics. The median length of stay in a pediatric emergency was 2 days. There were no deaths and none of the patients required mechanical ventilation. Conclusions: Based on this study, the use of continuous intravenous magnesium sulfate (dose of 50 mg/kg/h during 4 hours) proved to be safe and can be a satisfactory adjunctive therapy in the management of severe asthma after initial failure

QCDMAPT: program package for Analytic approach to QCD

A program package, which facilitates computations in the framework of Analytic approach to QCD, is developed and described in details. The package includes the explicit expressions for relevant spectral functions calculated up to the four-loop level and the subroutines for necessary integrals.Comment: 18 pages, 4 figures; QCDMAPT package is available from http://cpc.cs.qub.ac.uk/summaries/AEGP_v1_0.htm

Lingual Thyroid Ectopia: Diagnostic SPECT/CT Imaging and Radioactive Iodine Treatment

Background: Lingual thyroid is a rare abnormality of thyroid development that is usually treated conservatively with levothyroxine replacement. Rarely, it becomes large enough to cause obstructive symptoms in the oral cavity, requiring definitive treatment. Patient Findings: This study reports on three patients with lingual thyroid treated with radioactive iodine-131 (131I) with successful radioablation of their ectopic thyroid tissues. Measurement of 24-hour radioactive iodine uptake within thyroidal tissues and hybrid single-photon emission computed tomography/computed tomography imaging using either iodine-123 or technetium-99m pertechnetate scans were performed in all patients demonstrating the location and size of lingual thyroid and absence of an orthotopic thyroid gland. Summary: The aim of this study was to describe nonsurgical management of obstructive lingual thyroid tissue with 131I therapy for lingual thyroid radioablation. Patients were prepared with a low-iodine diet and levothyroxine withdrawal prior to radioablation for optimizing 131I uptake in ectopic thyroid tissues. Hybrid single-photon emission computed tomography/computed tomography measurement of anatomic size of lingual thyroid tissue and radioactive iodine uptake guided the selection of therapeutic doses, resulting in administration of 10.7, 17.5, and 15.4 mCi of 131I, respectively. There were no post-therapy complications, and clinical follow-up demonstrated resolution of obstructive oropharyngeal symptoms. Conclusions: Ectopic lingual thyroid tissue is rarely associated with obstructive oropharyngeal symptoms due to progressive enlargement. Radioiodine therapy with 131I is an effective treatment modality for ablation of ectopic thyroid tissue as an alternative to surgery.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140270/1/thy.2015.0396.pd

Fluorodeoxyglucose Positron Emission Tomography in Primary Thyroid Lymphoma with Coexisting Lymphocytic Thyroiditis

Background: Primary thyroid lymphoma is an uncommon neoplasm frequently associated with lymphocytic thyroiditis (LT). Once the pathologic diagnosis of primary thyroid lymphoma is established, imaging plays an important role in tumor staging and evaluating treatment response. The present case discusses the role of fluorodeoxyglucose positron emission tomography (18F-FDG PET)/computed tomography (CT) in this clinical setting along with the potential diagnostic challenges. Patient Findings: A 44-year-old man with a history of LT and hypothyroidism presented with an enlarging goiter. Initial imaging evaluation showed markedly enlarged gland with bilateral cervical and mediastinal adenopathy. Histopathologic evaluation confirmed the diagnosis of primary thyroid lymphoma on a background of LT. An 18F-FDG PET/CT revealed increased uptake in the gland and lymph nodes. Follow-up 18F-FDG PET/CT after chemotherapy showed interval decrease in FDG uptake in the thyroid gland associated with interval decrease in the size and metabolic activity of the cervical and superior mediastinal lymph nodes. Conclusions: The frequent association of LT with primary thyroid lymphoma and the overlap of their clinical and pathologic findings pose a significant diagnostic challenge. While other imaging techniques are helpful in evaluating anatomic local and regional extent of primary thyroid lymphoma, 18F-FDG PET/CT can be of an added value in evaluating its metabolic activity and detecting regional and distant disease as well as in assessing response to treatment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90467/1/thy-2E2011-2E0064.pd

Efficacy of radioactive iodine treatment of graves’ hyperthyroidism using a single calculated 131I dose

Abstract Objective To evaluate the success rate of therapeutic administration of a single calculated 131I activity for eliminating hyperthyroidism due to Graves’ disease. Methods and materials Patients with Graves’ hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated 131I activity of 0.2 mCi per estimated gram of thyroid tissue, adjusted for the 24-h RAIU. The goal of RAI treatment was to achieve hypothyroidism within 3–6 months of 131I administration. Response to RAI therapy was assessed at 7 weeks and 3 months by clinical and biochemical follow-up. Results The study included 316 hyperthyroid patients with Graves’ disease (F238:M78, mean age 42.1 ± 16 y, 4–94). 179 patients (56.6%) had no prior therapeutic intervention (treatment-naive patients), whereas 6 patients had prior thyroid surgery, and 131 (41.5%) had been treated with anti-thyroid medications. The mean estimated thyroid gland size was 50.2 g ± 18, range 15–100. Mean RAIU was 0.57 ± 0.17 (normal 0.07–0.30). RAI doses ranged from 5 to 70 mCi (mean dose = 18.1 mCi). Successful treatment of hyperthyroidism at our institution was obtained after a single therapeutic 131-I activity administration in 295 of 316 (93.3%) patients. Multivariate logistic regression analysis demonstrated that failure of 131I therapy was associated with previous PTU therapy (p <  0.001). The mean response time after successful RAI therapy was 110.2 days, with cumulative response of 25% at 61 days, 50% by 84 days and 75% by 118 days after radioiodine administration. The mean time to respond for those on prior PTU medications was 297 days compared to 116 days for those on MMI and 109 days for those not previously treated with antithyroid medications. In patients with persistent hyperthyroidism, failure of RAI therapy was documented in 16 patients (76.2%) within (less than) one year after 131I administration and in 5 patients (23.8%) more than one year after initial therapy, considered late failure. Conclusion Successful 131I therapy for Graves’ hyperthyroidism with a single calculated dose can be achieved in the majority (> 90%) of patients, adjusting for the thyroid size and 24 h uptake measurement.https://deepblue.lib.umich.edu/bitstream/2027.42/146543/1/40842_2018_Article_71.pd

Photon Propagation in Space-Time with a Compactified Spatial Dimension

The one-loop effects of vacuum polarization induced by untwisted fermions in QED in a nonsimply connected space-time with topology $S^{1}\times R^{3}$ are investigated. It is found that photon propagation in this system is anisotropic, appearing several massive photon modes and a superluminal transverse mode. For small compactification radius $a$, the superluminal velocity increases logarithmically with $a$. At low energies the photon masses lead to an effective confinement of the gauge fields into a (2+1)-dimensional manifold transverse to the compactified direction. The system shows a topologically induced directional superconductivity.Comment: 5 pages, to appear in PL

Echocardiographic Confirmation of Mitral Valve Prolapse: A New Finding on Radionuclide Ventriculography- A Case Report

A prominent filling defect was depicted on a radionuclide ventriculogram in a patient with mitral regurgitation. This defect was later shown, by cardiac ultrasound, to be due to mitral valve prolapse into the left ventricle during diastole. This case illustrates that mitral valve prolapse should be added to the list of clinical entities that can result in an intraventricular defect on a radionu clide ventriculogram.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67208/2/10.1177_000331978904000209.pd

Evolving paradigms for successful molecular imaging of medullary thyroid carcinoma

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