1,029 research outputs found
Study of Phase Reconstruction Techniques applied to Smith-Purcell Radiation Measurements
Measurements of coherent radiation at accelerators typically give the
absolute value of the beam profile Fourier transform but not its phase. Phase
reconstruction techniques such as Hilbert transform or Kramers Kronig
reconstruction are used to recover such phase. We report a study of the
performances of these methods and how to optimize the reconstructed profiles.Comment: Presented at IPAC'14 - THPME08
System thermal-hydraulic modelling of the phénix dissymmetric test benchmark
Phénix is a French pool-type sodium-cooled prototype reactor; before the definitive shutdown, occurred in 2009, a final set of experimental tests are carried out in order to increase the knowledge on the operation and the safety aspect of the pool-type liquid metal-cooled reactors. One of the experiments was the Dissymmetric End-of-Life Test which was selected for the validation benchmark activity in the frame of SESAME project. The computer code validation plays a key role in the safety assessment of the innovative nuclear reactors and the Phénix dissymmetric test provides useful experimental data to verify the computer codes capability in the asymmetric thermal-hydraulic behaviour into a pool-type liquid metal-cooled reactor. This paper shows the comparison of the outcomes obtained with six different System Thermal-Hydraulic (STH) codes: RELAP5-3D©, SPECTRA, ATHLET, SAS4A/SASSYS-1, ASTEC-Na and CATHARE. The nodalization scheme of the reactor was individually achieved by the participants; during the development of the thermal-hydraulic model, the pool nodalization methodology had a special attention in order to investigate the capability of the STH codes to reproduce the dissymmetric effects which occur in each loop and into pools, caused by the azimuthal asymmetry of the boundary conditions. The modelling methodology of the participants is discussed and the main results are compared in this paper to obtain useful guide lines for the future modelling of innovative liquid metal pool-type reactors
Consecutive episodes of heart and kidney failure in an "otherwise" healthy young man
Background: Acute renal failure is a rare occurrence in a patient with an unremarkable past medical history and should always lead to an in depth clinical study. The occurrence in the same healthy young subject, of consecutive episodes of heart failure and of acute renal failure is an even rarer event and should prompt diagnostic tests and restrict the diagnostic hypotheses. Case presentation: We present the case of a 28 year-old man who, while waiting to undergo assessment for a mild chronic kidney disease, was diagnosed with decompensated dilated cardiomyopathy and placed on diuretics and β-blockers. After few weeks he developed a non oligoanuric acute renal failure with a slight elevation of serum calcium. Renal biopsy proved suggestive for renal sarcoidosis; thus the hypothesis of systemic sarcoidosis with cardiac and renal involvement was possible avoiding further delay in initiation of therapy. Conclusions: Cardiac sarcoidosis is usually silent but the majority of cases are diagnosed when cardiac symptoms are present in a patient with systemic sarcoidosis. Renal involvement with granulomatous interstitial nephritis is also quite rare and can be an unexpected finding at kidney biopsy. This case highlights the need to evaluate thoroughly clinical problems that do not fit in a specific scenario and emphasizes the importance of performing a kidney biopsy in case of kidney failure of unknown etiology
Reversible catastrophic oxidation of a 38Fe-34Ni-25Cr alloy induced by sodium sulphate at low oxygen potential atmospheres
International audienceThe chromia-forming nickel-based alloy Haynes (R) HR-120 was oxidised with and without Na2SO4 deposit in a CO/H-2/CO2 (45/45/10%vol.) simulated process atmosphere at 900 degrees C for 96 h. During the first hours of oxidation, samples covered by sodium sulphate exhibit higher oxidation rate than non-covered ones. However, after 24 h both sulphate-covered and uncovered specimens follow the same linear kinetics. In this very low oxygen partial pressure environment (10(-18) atm), the presence of Na2SO4 promotes the growth of localized iron-rich oxide nodules leading to the observed accelerated oxidation. The development of these nodules is discussed to be the result of the chromia dissolution induced by a basic fluxing mechanism. As soon as the salt is evaporated, slower kinetics are observed and the nodules disappear. In these specific conditions, the oxidation could be considered as a self-healing process
High-speed Photometric Observations of ZZ Ceti White Dwarf Candidates
We present high-speed photometric observations of ZZ Ceti white dwarf
candidates drawn from the spectroscopic survey of bright DA stars from the
Villanova White Dwarf Catalog by Gianninas et al., and from the recent
spectroscopic survey of white dwarfs within 40 parsecs of the Sun by Limoges et
al. We report the discovery of six new ZZ Ceti pulsators from these surveys,
and several photometrically constant DA white dwarfs, which we then use to
refine the location of the ZZ Ceti instability strip.Comment: 4 pages, 1 table, 2 figures, to appear in "19th European White Dwarf
Workshop" in the ASP Conference Serie
Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.
Langerhans cell histiocytosis (LCH) is a rare disease caused by the clonal accumulation of dendritic Langerhans cells, which is often accompanied by osteolytic lesions. It has been reported that osteoclast-like cells play a major role in the pathogenic bone destruction seen in patients with LCH and these cells are postulated to originate from the fusion of DCs. However, due to the lack of reliable animal models the pathogenesis of LCH is still poorly understood. In this study, we have established a mouse model of histiocytosis- recapitulating human disease for osteolytic lesions seen in LCH patients. At 12 weeks after birth, severe bone lesions were observed in our multisystem histiocytosis (Mushi) model, when CD8α conventional dendritic cells (DCs) are transformed (MuTuDC) and accumulate. Most importantly, our study demonstrates that bone loss in LCH can be accounted for the transdifferentiation of MuTuDCs into functional osteoclasts both in vivo and in vitro. Moreover, we have shown that injected MuTuDCs reverse the osteopetrotic phenotype of oc/oc mice in vivo. In conclusion, our results support a crucial role of DCs in bone lesions in histiocytosis patients. Furthermore, our new model of LCH based on adoptive transfer of MuTuDC lines, leading to bone lesions within 1-2 weeks, will be an important tool for investigating the pathophysiology of this disease and ultimately for evaluating the potential of anti-resorptive drugs for the treatment of bone lesions
Recommended from our members
Operationalising and measuring language dominance
The paper offers a new way to measure language ability in bilinguals, based on measures of lexical richness. The validity of proposed approach is tested in a variety of ways
Multi‐scale studies of 3d printed Mn–Na–W/SiO2 catalyst for oxidative coupling of methane
This work presents multi-scale approaches to investigate 3D printed structured Mn–Na–W/SiO_{2} atalysts used for the oxidative coupling of methane (OCM) reaction. The performance of the 3D printed catalysts has been compared to their conventional analogues, packed beds of pellets and powder. The physicochemical properties of the 3D printed catalysts were investigated using scanning electron microscopy, nitrogen adsorption and X-ray diffraction (XRD). Performance and durability tests of the 3D printed catalysts were conducted in the laboratory and in a miniplant under real reaction conditions. In addition, synchrotron-based X-ray diffraction computed tomography technique (XRD-CT) was employed to obtain cross sectional maps at three different positions selected within the 3D printed catalyst body during the OCM reaction. The maps revealed the evolution of catalyst active phases and silica support on spatial and temporal scales within the interiors of the 3D printed catalyst under operating conditions. These results were accompanied with SEM-EDS analysis that indicated a homogeneous distribution of the active catalyst particles across the silica support
- …