Обеспечение точности обобщенной интервальной оценки качества изделий

Разработан метод интервальной оценки качества изделий, отличительной особенностью которого является получение весовых коэффициентов обобщенного показателя с использованием нечетких функций принадлежности гауссового типа. Их использование позволяет повысить точность и достоверность принятия решения при определении категории качества изделий различного целевого назначения в соответствии с вербально-числовой шкалой функции желательности Харрингтона.Розроблено метод інтервальної оцінки якості виробів, відмітною особливістю якого є отримання вагових коефіцієнтів узагальненого показника з використанням нечітких функцій приналежності гауссового типу. Їх використання дозволяє підвищити точність та вірогідність прийняття рішення під час визначення категорії якості виробів різного цільового призначення відповідно до вербально-числової шкали функції бажаності Харрінгтона.The method of interval estimation of the products’ quality, the distinctive feature of which is a receipt of gravimetric coefficients of the generalized index with the use of unclear membership functions of gauss type, is developed. Their usage allows to promote exactness and authenticity of decision-making at determination category of products’ quality of the different target destination in accordance with the verbally-numerical scale of desirability function of Harrington

The doubly negative matrix completion problem

An $n\times n$ matrix over the field of real numbers is a doubly negative matrix if it is symmetric, negative definite and entry-wise negative. In this paper, we are interested in the doubly negative matrix completion problem, that is when does a partial matrix have a doubly negative matrix completion. In general, we cannot guarantee the existence of such a completion. In this paper, we prove that every partial doubly negative matrix whose associated graph is a $p$-chordal graph $G$ has a doubly negative matrix completion if and only if $p=1$. Furthermore, the question of completability of partial doubly negative matrices whose associated graphs are cycles is addressed.Spanish DGI - BFM2001-0081-C03-02.Fundação para a Ciência e a Tecnologia (FCT) – Programa Operacional “Ciência, Tecnologia, Inovação” (POCTI)

On the Form Factor for the Unitary Group

We study the combinatorics of the contributions to the form factor of the group U(N) in the large $N$ limit. This relates to questions about semiclassical contributions to the form factor of quantum systems described by the unitary ensemble.Comment: 35 page

Unambiguous comparison of the states of multiple quantum systems

We consider N quantum systems initially prepared in pure states and address the problem of unambiguously comparing them. One may ask whether or not all $N$ systems are in the same state. Alternatively, one may ask whether or not the states of all N systems are different. We investigate the possibility of unambiguously obtaining this kind of information. It is found that some unambiguous comparison tasks are possible only when certain linear independence conditions are satisfied. We also obtain measurement strategies for certain comparison tasks which are optimal under a broad range of circumstances, in particular when the states are completely unknown. Such strategies, which we call universal comparison strategies, are found to have intriguing connections with the problem of quantifying the distinguishability of a set of quantum states and also with unresolved conjectures in linear algebra. We finally investigate a potential generalisation of unambiguous state comparison, which we term unambiguous overlap filtering.Comment: 20 pages, no figure

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2

Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and hypertension. However, the disorder is usually incompletely corrected by suppression of cortisol, suggesting additional and irreversible changes, perhaps in the kidney. To examine this further, we produced mice with targeted disruption of the 11β-HSD2 gene. Homozygous mutant mice (11β-HSD2(–/–)) appear normal at birth, but ∼50% show motor weakness and die within 48 hours. Both male and female survivors are fertile but exhibit hypokalemia, hypotonic polyuria, and apparent mineralocorticoid activity of corticosterone. Young adult 11β-HSD2(–/–) mice are markedly hypertensive, with a mean arterial blood pressure of 146 ± 2 mmHg, compared with 121 ± 2 mmHg in wild-type controls and 114 ± 4 mmHg in heterozygotes. The epithelium of the distal tubule of the nephron shows striking hypertrophy and hyperplasia. These histological changes do not readily reverse with mineralocorticoid receptor antagonism in adulthood. Thus, 11β-HSD2(–/–) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. J. Clin. Invest. 103:683–689 (1999

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice

Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine receptor-bearing leukocytes. Chemokines play important roles in leukocyte trafficking and blocking chemokines can effectively reduce renal leukocyte recruitment and subsequent renal damage. However, recent data indicate that blocking chemokine or chemokine receptor activity in renal disease may also exacerbate renal inflammation under certain conditions. An increasing amount of data indicates additional roles of chemokines in the regulation of innate and adaptive immune responses, which may adversively affect the outcome of interventional studies. This review summarizes available in vivo studies on the blockade of chemokines and chemokine receptors in kidney diseases, with a special focus on the therapeutic potential of anti-chemokine strategies, including potential side effects, in renal disease. Copyright (C) 2004 S. Karger AG, Basel

Potential barriers and facilitators for implementation of an integrated care pathway for hearing-impaired persons: an exploratory survey among patients and professionals

BACKGROUND: Because of the increasing costs and anticipated shortage of Ear Nose and Throat (ENT) specialists in the care for hearing-impaired persons, an integrated care pathway that includes direct hearing aid provision was developed. While this direct pathway is still under investigation, in a survey we examined expectations and potential barriers and facilitators towards this direct pathway, of patients and professionals involved in the pathway. METHODS: Two study populations were assessed: members of the health professions involved in the care pathway for hearing-impaired persons (general practitioners (GPs), hearing aid dispensers, ENT-specialists and clinical audiologists) and persons with hearing complaints. We developed a comprehensive semi-structured questionnaire for the professionals, regarding expectations, barriers, facilitators and conditions for implementation. We developed two questionnaires for persons with hearing complaints, both regarding evaluations and preferences, and administered them after they had experienced two key elements of the direct pathway: the triage and the hearing aid fitting. RESULTS: On average GPs and hearing aid dispensers had positive expectations towards the direct pathway, while ENT-specialists and clinical audiologists had negative expectations. Professionals stated both barriers and facilitators towards the direct pathway. Most professionals either supported implementation of the direct pathway, provided that a number of conditions were satisfied, or did not support implementation, unless roughly the same conditions were satisfied. Professionals generally agreed on which conditions need to be satisfied. Persons with hearing complaints evaluated the present referral pathway and the new direct pathway equally. Many, especially older, participants stated however that they would still visit the GP and ENT-specialist, even when this would not be necessary for reimbursement of the hearing aid, and found it important that the ENT-specialist or Audiological Centre evaluated their hearing aid. CONCLUSION: This study identified professional concerns about the direct pathway for hearing-impaired persons. Gaps exist in expectations amongst professions. Also gaps exist between users of the pathway, especially between age groups and regions. Professionals are united in the conditions that need to be fulfilled for a successful implementation of the direct pathway. Implementation on a regional level is recommended to best satisfy these conditions

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes

The myocyte enhancer factor 2 (MEF2) regulates transcription in cardiac myocytes and adverse remodeling of adult hearts. Activators of G protein-coupled receptors (GPCRs) have been reported to activate MEF2, but a comprehensive analysis of GPCR activators that regulate MEF2 has to our knowledge not been performed. Here, we tested several GPCR agonists regarding their ability to activate a MEF2 reporter in neonatal rat ventricular myocytes. The inflammatory mediator prostaglandin E2 (PGE2) strongly activated MEF2. Using pharmacological and protein-based inhibitors, we demonstrated that PGE2 regulates MEF2 via the EP3 receptor, the betagamma subunit of Gi/o protein and two concomitantly activated downstream pathways. The first consists of Tiam1, Rac1, and its effector p21-activated kinase 2, the second of protein kinase D. Both pathways converge on and inactivate histone deacetylase 5 (HDAC5) and thereby de-repress MEF2. In vivo, endotoxemia in MEF2-reporter mice induced upregulation of PGE2 and MEF2 activation. Our findings provide an unexpected new link between inflammation and cardiac remodeling by de-repression of MEF2 through HDAC5 inactivation, which has potential implications for new strategies to treat inflammatory cardiomyopathies