Lizzie Brown\u27s Tallahassee

Francis Elizabeth Brown, born in 1818, was the oldest daughter of Thomas Brown, governor of Florida from 1849 to 1853. In the winter of 1827-1828 her father, a dispirited Virginia planter, organized a caravan to move his family from his Rappahannock River farm to Leon County, Florida, some 800 miles away. Brown packed ten year old Lizzie, as Francis Elizabeth was affectionately known, her mother, her brother Jackson, and her three sisters, Mary, Mag, and Ginnie, into the family carriage. Followed by twenty planter friends and his 140 slaves, Brown led the party for two months through North and South Carolina, Georgia, and into Florida. At the time Tallahassee was only a rude village of perhaps 600 or 700 persons. Land had been purchased from the Indians, and the Capital had been officially located only four years earlier. It was here in Leon County that Lizzie was to spend the greater part of her life. She was well educated for those days, and her family was one of the most politically and socially influential in all of antebellum Florida. She was considered to be a great belle. Governor DuVal in 1839 penned a poem “To Miss Lizzy Brown,” and in it he described her brown eyes as “burning with love and constancy.” Some time prior to 1847 the W. H. Geib Company of New York published the “Texas Waltz for the Piano Forte composed and respectfully dedicated to Miss Lizzy Brown,” composed by B. Lignouski, a local Tallahassee music teacher and future college instructor

A Letter from Occupied Tallahassee

Beigadier General Edward M. McCook, a thirty-two year old Union cavalry officer, accompanied by five staff officers, and units from the Second Indiana Cavalry and Seventh Kentucky Cavalry, numbering about 500 men, left Macon, Georgia, on May 5, 1865. He was under orders to accept the surrender of Confederate forces at Tallahassee and St. Marks. Leaving his cavalry four miles behind on the Thomasville Road, McCook and his officers quietly rode into Tallahassee and there on May 10 they received the surrender by Major General Samuel Jones of Florida’s Confederate forces. Two days later McCook received the surrender of the fort at St. Marks. In a special ceremony on May 20, the Union flag was raised over the state capitol with Acting Governor Abraham Allison, Florida officials, and a crowd of Tallahassee citizens quietly witnessing the sad event. The long and bloody war was over for the people of Florida and the military occupation of their state had begun

An evaluation of a model for the systematic documentation of hospital based health promotion activities: results from a multicentre study

BACKGROUND: The first step of handling health promotion (HP) in Diagnosis Related Groups (DRGs) is a systematic documentation and registration of the activities in the medical records. So far the possibility and tradition for systematic registration of clinical HP activities in the medical records and in patient administrative systems have been sparse. Therefore, the activities are mostly invisible in the registers of hospital services as well as in budgets and balances.A simple model has been described to structure the registration of the HP procedures performed by the clinical staff. The model consists of two parts; first part includes motivational counselling (7 codes) and the second part comprehends intervention, rehabilitation and after treatment (8 codes).The objective was to evaluate in an international study the usefulness, applicability and sufficiency of a simple model for the systematic registration of clinical HP procedures in day life. METHODS: The multi centre project was carried out in 19 departments/hospitals in 6 countries in a clinical setup. The study consisted of three parts in accordance with the objectives.A: Individual test. 20 consecutive medical records from each participating department/hospital were coded by the (coding) specialists at local department/hospital, exclusively (n = 5,529 of 5,700 possible tests in total).B: Common test. 14 standardized medical records were coded by all the specialists from 17 departments/hospitals, who returned 3,046 of 3,570 tests.C: Specialist evaluation. The specialists from the 19 departments/hospitals evaluated if the codes were useful, applicable and sufficient for the registration in their own department/hospital (239 of 285). RESULTS: A: In 97 to 100% of the local patient pathways the specialists were able to evaluate if there was documentation of HP activities in the medical record to be coded.B: Inter rater reliability on the use of the codes were 93% (57 to 100%) and 71% (31 to 100%), respectively.C: The majority of the study participants found the codes to be useful (71%), applicable (92%) and sufficient (92%). CONCLUSION: Systematic registration of HP activities is relevant in clinical day life and the suggested codes proved to be applicable for international use. HP is an essential part of the clinical pathway or the value chain. This model promises to improve the documentation and thereby facilitate analysis of records for evidence based medicine as well as cost and policy analyses

Involvement of patients or their representatives in quality management functions in EU hospitals:implementation and impact on patient-centred care strategies

OBJECTIVE: The objective of this study was to describe the involvement of patients or their representatives in quality management (QM) functions and to assess associations between levels of involvement and the implementation of patient-centred care strategies. DESIGN: A cross-sectional, multilevel STUDY DESIGN: that surveyed quality managers and department heads and data from an organizational audit. SETTING: Randomly selected hospitals (n = 74) from seven European countries (The Czech Republic, France, Germany, Poland, Portugal, Spain and Turkey). PARTICIPANTS: Hospital quality managers (n = 74) and heads of clinical departments (n = 262) in charge of four patient pathways (acute myocardial infarction, stroke, hip fracture and deliveries) participated in the data collection between May 2011 and February 2012. MAIN OUTCOME MEASURES: Four items reflecting essential patient-centred care strategies based on an on-site hospital visit: (1) formal survey seeking views of patients and carers, (2) written policies on patients' rights, (3) patient information literature including guidelines and (4) fact sheets for post-discharge care. The main predictors were patient involvement in QM at the (i) hospital level and (ii) pathway level. RESULTS: Current levels of involving patients and their representatives in QM functions in European hospitals are low at hospital level (mean score 1.6 on a scale of 0 to 5, SD 0.7), but even lower at departmental level (mean 0.6, SD 0.7). We did not detect associations between levels of involving patients and their representatives in QM functions and the implementation of patient-centred care strategies; however, the smallest hospitals were more likely to have implemented patient-centred care strategies. CONCLUSIONS: There is insufficient evidence that involving patients and their representatives in QM leads to establishing or implementing strategies and procedures that facilitate patient-centred care; however, lack of evidence should not be interpreted as evidence of no effect

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

The Dnmt2 enzyme utilizes the catalytic mechanism of eukaryotic DNA methyltransferases to methylate several tRNAs at cytosine 38. Dnmt2 mutant mice, flies, and plants were reported to be viable and fertile, and the biological function of Dnmt2 has remained elusive. Here, we show that endochondral ossification is delayed in newborn Dnmt2-deficient mice, which is accompanied by a reduction of the haematopoietic stem and progenitor cell population and a cell-autonomous defect in their differentiation. RNA bisulfite sequencing revealed that Dnmt2 methylates C38 of tRNA Asp(GTC), Gly(GCC), and Val(AAC), thus preventing tRNA fragmentation. Proteomic analyses from primary bone marrow cells uncovered systematic differences in protein expression that are due to specific codon mistranslation by tRNAs lacking Dnmt2-dependent methylation. Our observations demonstrate that Dnmt2 plays an important role in haematopoiesis and define a novel function of C38 tRNA methylation in the discrimination of near-cognate codons, thereby ensuring accurate polypeptide synthesis

Electron Density Distributions in Saturn's Ionosphere

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.Between 26 April and 15 September 2017, Cassini executed 23 highly inclined Grand Finale orbits through a new frontier for space exploration, the narrow region between Saturn and the D Ring, providing the first opportunity for obtaining in situ ionospheric measurements. During the Grand Finale orbits, the Radio and Plasma Wave Science instrument observed broadband whistler mode emissions and narrowband upper hybrid frequency emissions. Using known wave propagation characteristics of these two plasma wave modes, the electron density is derived over a broad range of ionospheric latitudes and altitudes. A two‐part exponential scale height model is fitted to the electron density measurements. The model yields a double‐layered ionosphere with plasma scale heights of 545/575 km for the northern/southern hemispheres below 4,500 km and plasma scale heights of 4,780/2,360 km for the northern/southern hemispheres above 4,500 km. The interpretation of these layers involves the interaction between the rings and the ionosphere