The Graduate Education Initiative: Description and Preliminary Findings

[Excerpt] In1991 the Andrew W. Mellon Foundation launched the Graduate Education Initiative (hereafter GEI) to improve the structure and organization of PhD programs in the humanities and social sciences. Such changes were seen as necessary to combat high rates of student attrition and long times-to-degree in these programs. While attrition and time-to-degree were deemed to be important in and of themselves, and of great significance to degree seekers, they were also seen more broadly as indicators of the effectiveness of graduate programs. Several characteristics of doctoral programs were earmarked as contributing to high attrition and long degree time, including: unclear expectations, a proliferation of courses, elaborate and sometimes conflicting requirements, intermittent supervision, epistemological disagreements on fundamentals and not least, inadequate funding. Projections that faculty shortages would occur in the late 1990s in the humanities made the goals of reducing student attrition and time-to-degree particularly timely if an adequate number of PhDs were to be available. This was far from the first such effort to reduce times-to degree-and rates of attrition. Earlier programs, which provided grants in aid to individual students or to graduate schools to distribute as they saw fit, had failed conspicuously. Based on data which showed that there were marked differences among departments and on a great deal of experience on the ground, the architects of the GEI determined that to improve graduate education would require departments to make changes in their PhD programs. As such, the Foundation shifted much of its support for doctoral education, which had previously gone directly to students, to block grants that would be awarded to departments within major universities

Optimizing the Post Sandvik Nanoflex material model using inverse optimization and the finite element method

This article describes an inverse optimization method for the Sandvik Nanoflex steel in cold forming\ud processes. The optimization revolves around measured samples and calculations using the Finite Element\ud Method. Sandvik Nanoflex is part of the group of meta-stable stainless steels. These materials are characterized\ud by a good corrosion resistance, high strength, good formability and crack resistance. In addition, Sandvik\ud Nanoflex has a strain-induced transformation and, depending on austenising conditions and chemical composition,\ud a stress-assisted transformation can occur. The martensite phase of this material shows a substantial aging\ud response. The inverse optimization is a sub-category of the optimization techniques. The inverse optimization\ud method uses a top down approach, as the name implies. The starting point is a prototype state where the current\ud state is to converge on. In our experiment the test specimen is used as prototype and a calculation result as\ud current state. The calculation is then adapted so that the result converges towards the test example. An iterative\ud numerical optimization algorithm controls the adaptation. For the inverse optimization method two parameters\ud are defined: shape of the product and martensite profile. These parameters are extracted from both calculation\ud and test specimen, using Fourier analysis and integrals. An optimization parameter is then formulated from\ud the extracted parameters. The method uses this optimization parameter to increase the accuracy of ”The Post”\ud material model for Sandvik Nanoflex. [1] The article will describe a method to optimize material models, using\ud a combination practical experiments, Finite Element Method and parameter extraction

Takings Law, Lucas, and the Growth Management Act

In light of Lucas and the recent constitutionally questionable Washington decisions, government entities charged with implementing the GMA may have a more difficult time avoiding takings liability than previously thought. Accordingly, this Article first seeks to clarify the modern takings analysis as refined by Lucas. Second, Washington takings precedent is contrasted with the federal approach and several key changes are suggested to make state law consistent with controlling federal precedent. Third, key aspects of the GMA are identified that can be expected to raise takings implications. By identifying potential trouble spots in the GMA now, hopefully some takings will be avoided without resort to litigation in the future

Entanglement genesis by ancilla-based parity measurement in 2D circuit QED

We present an indirect two-qubit parity meter in planar circuit quantum electrodynamics, realized by discrete interaction with an ancilla and a subsequent projective ancilla measurement with a dedicated, dispersively coupled resonator. Quantum process tomography and successful entanglement by measurement demonstrate that the meter is intrinsically quantum non-demolition. Separate interaction and measurement steps allow commencing subsequent data qubit operations in parallel with ancilla measurement, offering time savings over continuous schemes.Comment: 5 pages, 4 figures; supplemental material with 5 figure

Required Evidence for Clinical Applications of Liquid Biopsy Using Especially CTCs in Lung Cancer

As therapies have become more and more dependent on tumor as well as patient characteristics, obtaining tumor material has become of great importance. Liquid biopsies hold much potential as shown by a large amount of evidence across several studies. Clinical applications for circulating tumor cells (CTCs) are unfortunately still lacking. In part this is due to a lack of studies comparing liquid biopsies to conventional diagnostics and response measurements as well as studies showing that liquid biopsies can be used to switch therapies leading to improved outcomes. However, liquid biopsies using ctDNA for specific markers such as EGFR, ALK, ROS1 or RET have clinical applications because specific drugs are available

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing?

The recent outbreak of Marburg haemorrhagic fever in the Democratic Republic of Congo has put the filovirus threat back on the international health agenda. This paper gives an overview of Marburg and Ebola outbreaks so far observed and puts them in a public health perspective. Damage on the local level has been devastating at times, but was marginal on the international level despite the considerable media attention these outbreaks received. The potential hazard of outbreaks, however, after export of filovirus from its natural environment into metropolitan areas, is argued to be considerable. Some avenues for future research and intervention are explored. Beyond the obvious need to find the reservoir and study the natural history, public health strategies for a more timely and efficient response are urgently needed