28 research outputs found

    Urazowe uszkodzenie mózgu = Traumatic brain injury

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    Kulesza Bartłomiej, Litak Jakub, Grochowski Cezary, Kulesza Jacek, Nogalski Adam. Urazowe uszkodzenie mózgu = Traumatic brain injury. Journal of Education, Health and Sport. 2016;6(12):215-221.eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.197104http://ojs.ukw.edu.pl/index.php/johs/article/view/4044https://pbn.nauka.gov.pl/sedno-webapp/works/763747   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 02.11.2016. Revised 22.11.2016. Accepted: 07.12.2016.   Urazowe uszkodzenie mózguTraumatic brain injuryBartłomiej Kulesza1, Jakub Litak2, Cezary Grochowski2, Jacek Kulesza3, Adam Nogalski1 1 Katedra i Klinika Chirurgii Urazowej i Medycyny Ratunkowej Uniwersytetu Medycznego w Lublinie2 Katedra i Klinika Neurochirurgii i Neurochirurgii Dziecięcej Uniwersytetu Medycznego w Lublinie3 Oddział Neurochirurgiczny, Szpital Specjalistyczny w Sandomierzu lek. med. Bartłomiej Kulesza1,lek. med. Jakub Litak2,lek. med.  Cezary Grochowski2,dr n. med. Jacek Kulesza3,dr hab. n. med. Adam Nogalski1  StreszczenieUrazowe uszkodzenie mózgu (TBI)  nie jest właściwie jedną chorobą,  ale obejmuje szeroki zakres zmian w funkcjonowaniu mózgu lub inną ewidentną patologią mózgu spowodowaną zadziałaniem siły zewnętrznej.  TBI jest często określane mianem „cichej epidemii”.  Szacuje się że w Europie każdego roku z powodu jakieś formy TBI cierpi 2,5 miliona osób.  Patologiczny mechanizm TBI można podzielić na dwie fazy: pierwotne i wtórne uszkodzenie mózgu.  Są różne skale służące do oceny poszkodowanych po urazach, w przypadku urazów głowy największe znaczenie ma skala stanu świadomości Glasgow (GCS).  Najczęściej stosowana skala do oceny wyników leczenia chorych po TBI jest skala wyników leczenia Glasgow (GOS).  Rokowanie po TBI jest z reguły niekorzystne, można je próbować oszacować uwzględniając wiele czynników lub korzystając z dwóch kalkulatorów prognostycznych dostępnych w Internecie.Słowa kluczowe: urazowe uszkodzenie mózgu, epidemiologia, skala, rokowanieAbstractTraumatic brain injury (TBI) is not just one disease, but includes a wide spectrum alteration in brain function, or other evidence of brain pathology caused by external force. TBI is often referred to as "the silent epidemic". In Europe, it is estimated approximately 2,5 milion people suffer from some form of TBI.  The pathological mechanism of TBI is divided into two phases: primary and secondary brain injury. There are various scales to assess victims after injuries,  in case of head injuries the most important is Glasgow Coma Scale (GCS). The most common scale used to evaluate the results of treatment of patients after TBI is Glasgow Outcome Scale (GOS). The prognosis after TBI is generally unfavorable, there are a few factors which can try to assess outcomes or there are two prognostic calculators available on the Internet.Key words: traumatic brain injury, epidemiology, scale, outcom

    Design status of ASPIICS, an externally occulted coronagraph for PROBA-3

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    The "sonic region" of the Sun corona remains extremely difficult to observe with spatial resolution and sensitivity sufficient to understand the fine scale phenomena that govern the quiescent solar corona, as well as phenomena that lead to coronal mass ejections (CMEs), which influence space weather. Improvement on this front requires eclipse-like conditions over long observation times. The space-borne coronagraphs flown so far provided a continuous coverage of the external parts of the corona but their over-occulting system did not permit to analyse the part of the white-light corona where the main coronal mass is concentrated. The proposed PROBA-3 Coronagraph System, also known as ASPIICS (Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun), with its novel design, will be the first space coronagraph to cover the range of radial distances between ~1.08 and 3 solar radii where the magnetic field plays a crucial role in the coronal dynamics, thus providing continuous observational conditions very close to those during a total solar eclipse. PROBA-3 is first a mission devoted to the in-orbit demonstration of precise formation flying techniques and technologies for future European missions, which will fly ASPIICS as primary payload. The instrument is distributed over two satellites flying in formation (approx. 150m apart) to form a giant coronagraph capable of producing a nearly perfect eclipse allowing observing the sun corona closer to the rim than ever before. The coronagraph instrument is developed by a large European consortium including about 20 partners from 7 countries under the auspices of the European Space Agency. This paper is reviewing the recent improvements and design updates of the ASPIICS instrument as it is stepping into the detailed design phase

    How were Greeks “buying”? Remarks to Gaius’ commentary regarding a purchase contract (Gai. 3.141)

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    The article discusses the problem what an ancient trade contract was called. Did Greeks perceive it only as a barter exchange or a purchase agreement? Perhaps this difference was insignificant or irrelevant? In order to solve this mystery the author follows the footsteps of Gaius’ way of thinking, dating back to the Roman times. Although Homer cannot be considered a jurist, his texts provided Gaius with valuable input. They enabled the ancient jurist to a make well-grounded point in one of the most renown juridical discussion of ancient times between Sabinians and Proculians. The author analyzed Gaius’ text and searched for the original sense of Homer’s poetry so as to rediscover the true nature of an original trade transaction in ancient Greece

    Etnofon. Jak udostępniać dokumentalne nagrania muzyki ludowej? Z Jackiem Jackowskim rozmawia Piotr Grochowski

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    Jacek Jackowski is a musician and ethnomusicologist, and the head of the Phonographic Collection at the Institute of Art of the Polish Academy of Sciences. He specializes in the conservation, digitization and archiving of old sound recordings. He is a field researcher and author of many academic articles on traditional, Catholic and folk religious culture associated with musical behaviours. He also published numerous articles and books on early folk music recordings and their digitization (Zachować dawne nagrania, Warszawa 2014; Polska muzyka tradycyjna – dziedzictwo fonograficzne, t. 1, Warszawa 2017; t. 2, Warszawa 2019), as well as 17 CD albums of folk songs and music from Kashubia, Kurpie, Podhale, Łowicz, Orava, South Wielkopolska and many other regions of Poland. Since 2014 he has been managing the Etnofon project, the goal of which is to create, develop and maintain a central digital repository of documentary phonographic and film recordings capturing Polish traditional songs and music as well as folk dance

    PD-L1/PD-1 Axis in Glioblastoma Multiforme

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    Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an extremely expansive course. Aggressive tumor growth correlates with short median overall survival (OS) oscillating between 14 and 17 months. The survival rate of patients in a three-year follow up oscillates around 10%. The interaction of the proteins programmed death-1 (PD-1) and programmed cell death ligand (PD-L1) creates an immunoregulatory axis promoting invasion of glioblastoma multiforme cells in the brain tissue. The PD-1 pathway maintains immunological homeostasis and protects against autoimmunity. PD-L1 expression on glioblastoma surface promotes PD-1 receptor activation in microglia, resulting in the negative regulation of T cell responses. Glioblastoma multiforme cells induce PD-L1 secretion by activation of various receptors such as toll like receptor (TLR), epidermal growth factor receptor (EGFR), interferon alpha receptor (IFNAR), interferon-gamma receptor (IFNGR). Binding of the PD-1 ligand to the PD-1 receptor activates the protein tyrosine phosphatase SHP-2, which dephosphorylates Zap 70, and this inhibits T cell proliferation and downregulates lymphocyte cytotoxic activity. Relevant studies demonstrated that the expression of PD-L1 in glioma correlates with WHO grading and could be considered as a tumor biomarker. Studies in preclinical GBM mouse models confirmed the safety and efficiency of monoclonal antibodies targeting the PD-1/PD-L1 axis. Satisfactory results such as significant regression of tumor mass and longer animal survival time were observed. Monoclonal antibodies inhibiting PD-1 and PD-L1 are being tested in clinical trials concerning patients with recurrent glioblastoma multiforme
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