Determination of bonding parameters and inspection techniques for cadmium-to-stainless steel bonds and assembly of two capsule housings Final report

Bonding parameters and quality control for cadmium-stainless steel clad fuel pellet containment vessel productio

Porous mandrels provide uniform deformation in hydrostatic powder metallurgy

Porous copper mandrels prevent uneven deformation of beryllium machining blanks. The beryllium powder is arranged around these mandrels and hot isostatically pressed to form the blanks. The mandrels are then removed by leaching

Writing Systems as a Reflection of Ancient Societies

This thesis examines the writing systems of two ancient societies: the Latin alphabet as a writing system within the Roman Empire and the hieroglyphic writing system within the Maya city-state. This thesis first situates writing as a technology and explains the common uses of writing systems in modern contexts, before turning to an examination of the past. Next, basic literary patterns—including estimated literacy rates, education patterns and opportunities, types of documents, and themes within writing—are examined within the context of both societies. After evaluating these literary patterns, as well as the social, political, and economic organization of both societies, this thesis examines the relationship between these writing systems and their respective societies. The literary patterns discussed in the context of these writing systems reflect the previously discussed socio-political-economic hierarchies within the two farming societies. Additionally, these literary patterns are used to examine the reflection of a society’s food surplus—one based on wheat within the Roman Empire and one supported by maize in the Maya city-state—within written documents, as well as the differences formed among these farming societies due to their respective forms of subsistence

Investigating the effects of Perfluorooctanoic Sulfonate (PFOS) and ethanol on fatty liver disease using a modified NIAAA model.

Perfluoroalkyl Substances (PFAS) are a family of man-made, surfactant-like compounds that are a major environmental contaminant. A multitude of studies have indicated that PFAS are able to induce fatty liver disease and modulate lipid metabolism. However, the distinct mechanism of PFAS influence on the liver and metabolism disruption remains to be elucidated. On the other hand, it is well documented that alcohol consumption has various adverse health impacts including fatty liver disease and subsequent progression to more adverse liver states. To date, there are no published studies on whether PFAS and alcohol can jointly exacerbate fatty liver progression or interact to disturb lipid metabolism. It is hypothesized that PFOS and alcohol will interact to exacerbate fatty liver but co-independently modulate metabolism. This study seeks to characterize the phenotype after male C57BL/6 mice are exposed to Perfluorooctanoic Sulfonate (PFOS), a prominent PFAS, while ad libitum consuming an alcohol diet

The development and diffusion of the Tennessee walking horse : a case study in equine regional specialization

By the early 20th century, the Tennessee Walking Horse emerged as a distinct American horse breed in Nashville Basin in Middle Tennessee. The Walking Horse developed in Tennessee largely as a result of equine and human diffusion, preexisting breeding and sales infrastructure, regional demand for a specific type, the evolution of a complex and complimentary equine gene pool, and growing interest in recreational horse breeds. The Tennessee Walking Horse breed registry was organized in 1935 but Walking Horse diffusion patterns that persisted through the late 1980s were established as early as the 1920s. A model for equine regional specialization was developed based on the spatial characteristics of Walking Horse marketing patterns. This model can also be applied to other purebred livestock. The data set was constructed from registration papers held by the Tennessee Walking Horse Breeders\u27 and Exhibitors\u27 Association. The spatial relationships between breeders and buyers were mapped using county-level import and export sales characteristics to identify areas with the most intensive development. The overall trend in Walking Horse diffusion from its Middle Tennessee hearth is for horses to be sold most often to owners south and west with smaller numbers of sales north and east. By the 1990s, Walking Horses had diffused from their Middle Tennessee hearth to every U.S. state and many foreign countries. Although their diffusion may appear to be extensive, the rate of adoption has been slow in some regions due to the presence of previously established horse breeds, prejudice against gaited horses, and the popularity of other incompatible equine activities

Space shuttle transportation system techniques for user/use development

The problem of obtaining new uses for the Shuttle Transportation System (STS) was treated in the same way marketing problems are handled by industrial organizations. Techniques used by industry to obtain new ideas and customers were evaluated and analyzed for their relevance to the STS. Marketing barrier-data were used to develop strategy which called for a middleman organization to assist NASA in achieving its objectives. The importance of prompt initiation of the recommended strategy was established

Advanced Beryllium Gyro Technology

This paper describes the process developed for fabricating beryllium gyro components by hot isostatic pressing. Five different components, an inner gimbal, a gyro sleeve, an accelerometer sleeve, an inner cylinder, and an inner cylinder cover, were fabricated. Although the process varied somewhat for each type of specimen, it consisted primarily of vibratory packing, hydrostatic pressing, hot isostatic pressing, and leaching. Since the most challenging component to be fabricated was the inner gimbal, this paper is devoted primarily to the process development of this particular component. Two key developments associated with the fabrication of the inner gimbal were the use of a deformable mandrel and the use of a new type of pressure-transmitting medium. The use of a porous copper mandrel allowed even deformation of the preform during cold hydropressing and, as a result, very accurate pressings could be made. A sodium chloride pressure-transmitting layer around the green compact allowed sealing of the irregular shape in a cylindrical pressing container

Selective Inhibition of CTCF Binding by iAs Directs TET-Mediated Reprogramming of 5-Hydroxymethylation Patterns in iAs-Transformed Cells

Methylation at cytosine (5mC) is a fundamental epigenetic DNA modification recently associated with iAs-mediated carcinogenesis. In contrast, the role of 5-hydroxymethylcytosine (5hmC), the oxidation product of 5mC in iAs-mediated carcinogenesis is unknown. Here we assess the hydroxymethylome in iAs-transformed cells, showing that dynamic modulation of hydroxymethylated DNA is associated with specific transcriptional networks. Moreover, this pathologic iAs-mediated carcinogenesis is characterized by a shift toward a higher hydroxymethylation pattern genome-wide. At specific promoters, hydroxymethylation correlated with increased gene expression. Furthermore, this increase in hydroxymethylation occurs concurrently with an upregulation of ten-eleven translocation (TET) enzymes that oxidize 5-methylcytosine (5mC) in DNA. To gain an understanding into how iAs might impact TET expression, we found that iAs inhibits the binding of CTCF at the proximal, weak CTCF binding sites of the TET1 and TET2 gene promoters and enhances CTCF binding at the stronger distal binding site. Further analyses suggest that this distal site acts as an enhancer, thus high CTCF occupancy at the enhancer region of TET1 and TET2 possibly drives their high expression in iAs-transformed cells. These results have major implications in understanding the impact of differential CTCF binding, genome architecture and its consequences in iAs-mediated pathogenesis

A study of vacancies in tungsten quenched in superfluid helium

Thesis (Ph. D.)--Michigan State University. Department of Physics, 1969Includes bibliographical references (pages 97-99