Stochastic Dominance Analysis of Bioenergy Crops as a Production Alternative on an East Tennessee Beef and Crop Farm

This study evaluated prices and incentives for switchgrass stated in a biorefinery’s contract terms that induce switchgrass production on an east Tennessee representative farm when compared with traditional enterprises. The alternate contract terms imitated current subsidies/incentives offered as well as incentives and cost share terms not in the BCAP.switchgrass, contract, risk aversion, net return, Farm Management, Production Economics, Resource /Energy Economics and Policy, Q12,

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor.

Signaling through growth factor receptors controls such diverse cell functions as proliferation, migration, and differentiation. A critical question has been how the activation of these receptors is regulated. Most, if not all, of the known ligands for these receptors are soluble factors. However, as matrix components are highly tissue-specific and change during development and pathology, it has been suggested that select growth factor receptors might be stimulated by binding to matrix components. Herein, we describe a new class of ligand for the epidermal growth factor (EGF) receptor (EGFR) found within the EGF-like repeats of tenascin-C, an antiadhesive matrix component present during organogenesis, development, and wound repair. Select EGF-like repeats of tenascin-C elicited mitogenesis and EGFR autophosphorylation in an EGFR-dependent manner. Micromolar concentrations of EGF-like repeats induced EGFR autophosphorylation and activated extracellular signal-regulated, mitogen-activated protein kinase to levels comparable to those induced by subsaturating levels of known EGFR ligands. EGFR-dependent adhesion was noted when the ligands were tethered to inert beads, simulating the physiologically relevant presentation of tenascin-C as hexabrachion, and suggesting an increase in avidity similar to that seen for integrin ligands upon surface binding. Specific binding to EGFR was further established by immunofluorescence detection of EGF-like repeats bound to cells and cross-linking of EGFR with the repeats. Both of these interactions were abolished upon competition by EGF and enhanced by dimerization of the EGF-like repeat. Such low affinity behavior would be expected for a matrix-tethered ligand; i.e., a ligand which acts from the matrix, presented continuously to cell surface EGF receptors, because it can neither diffuse away nor be internalized and degraded. These data identify a new class of insoluble growth factor ligands and a novel mode of activation for growth factor receptors

Scattering in an environment

The cross section of elastic electron-proton scattering taking place in an electron gas is calculated within the Closed Time Path method. It is found to be the sum of two terms, one being the expression in the vacuum except that it involves dressing due to the electron gas. The other term is due to the scattering particles-electron gas entanglement. This term dominates the usual one when the exchange energy is in the vicinity of the Fermi energy. Furthermore it makes the trajectories of the colliding particles more consistent and the collision more irreversible, rendering the scattering more classical in this regime.Comment: final version to appear in Phys. Rev.

Breaking a one-dimensional chain: fracture in 1 + 1 dimensions

The breaking rate of an atomic chain stretched at zero temperature by a constant force can be calculated in a quasiclassical approximation by finding the localized solutions ("bounces") of the equations of classical dynamics in imaginary time. We show that this theory is related to the critical cracks of stressed solids, because the world lines of the atoms in the chain form a two-dimensional crystal, and the bounce is a crack configuration in (unstable) mechanical equilibrium. Thus the tunneling time, Action, and breaking rate in the limit of small forces are determined by the classical results of Griffith. For the limit of large forces we give an exact bounce solution that describes the quantum fracture and classical crack close to the limit of mechanical stability. This limit can be viewed as a critical phenomenon for which we establish a Levanyuk-Ginzburg criterion of weakness of fluctuations, and propose a scaling argument for the critical regime. The post-tunneling dynamics is understood by the analytic continuation of the bounce solutions to real time.Comment: 15 pages, 5 figure

The Impact of a Visual Cheap Talk Script in an Online Choice Experiment

Hypothetical bias causes willingness to pay (WTP) values to be inaccurate and is a prevalent issue in choice experiments. Research has shown that a “cheap talk” script may reduce hypothetical bias ; however, it is uncertain which cheap talk script format is the best at controlling hypothetical bias . Therefore, we conduct a choice experiment using a between-subjects design in which half of the articipants saw a “visual” cheap talk script and  half saw a “text” cheap talk script prior to the choice sets. Random parameter logit model results indicate hypothetical bias was more prevalent when participants saw the visual cheap talk script compared to the more conventional text cheap talk script. Text learners also appeared to be less prone to hypothetical bias than visual learners

Faculty and Student Issues with Group Work: What is Problematic with College Group Assignments and Why?

Embry-Riddle Aeronautical University researchers analyzed 811 (118 faculty and 693 student) comments to determine perceptions of group work in the academic setting. The biggest issue noted by both groups was allocation of grades for group members. Students perceived that all students received the same grade in a group project, regardless of effort. Most faculties did not share that perception, but noted difficulties in assigning group grades as well. Faculty and students described difficulties encountered by students when working on group projects in online or distance learning settings due to limited interaction and time zone differences and/or different work schedules. Faculty and students also encouraged faculty to closely monitor group projects and mentor students through group formation and goal setting. Recommendations include future research on age, gender, ethnic background relative to group projects, and case studies identifying best practices and identification on where group projects should be placed in a college curriculum

From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments

Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus. Members of the family include the industrially important species Lactococcus lactis, which has a long history safe use in the fermentative food industry, and the disease-causing streptococci Streptococcus pneumoniae and Streptococcus pyogenes. The central metabolic pathways of the Streptococcaceae family have been extensively studied because of their relevance in the industrial use of some species, as well as their influence on virulence of others. Recent developments in high-throughput proteomic and DNA-microarray techniques, in in vivo NMR studies, and importantly in whole-genome sequencing have resulted in new insights into the metabolism of the Streptococcaceae family. The development of cost-effective high-throughput sequencing has resulted in the publication of numerous whole-genome sequences of lactococcal and streptococcal species. Comparative genomic analysis of these closely related but environmentally diverse species provides insight into the evolution of this family of LAB and shows that the relatively small genomes of members of the Streptococcaceae family have been largely shaped by the nutritionally rich environments they inhabit.

Sputter Crater Contour Mapping with Multilayered Films

Multilayered films composed of alternating 200 Å Al and 267 Å Al203 layers are made by physical vapor deposition. Twenty-two pairs of these films are deposited on a polished Si wafer. Ion beam sputtering is used to form craters in the multilayered film. When a crater is viewed or photographed in situ by scanning electron microscopy, the Al2O3 layers appear bright and the Al layers appear dark. In the scanning electron microscope (SEM) the Al2O3 layers have a high secondary electron yield compared to Al. In secondary ion mass spectrometry (SIMS), using Cs+ as the ion beam, imaging with O- produces an image with Al2O3 layers appearing white and with Al layers appearing dark. Scanning Auger microscopy (SAM) imaging of oxygen produces the same result. In all cases, the alternating bright and dark layers along the wall of the sputter crater form a contour map. The width of each bright band represents a change of depth corresponding to the thickness of the Al2O3 layer and similarly for the dark Al bands. Therefore, the operator of a SEM, SAM or SIMS unit can determine the depth as well as the shape of a sputter crater in situ by using a multilayered film. The main requirement is that the films be smooth on a scale that is small compared to the thickness of each layer and that alternate films have high contrast in the imaging process

pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens

Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tumor-specific mutant peptides (neoantigens) can elicit anti-tumor T cell immunity are needed to improve predictions of checkpoint therapy response and to identify targets for vaccines and adoptive T cell therapies. Here, we present a flexible, streamlined computational workflow for identification of personalized Variant Antigens by Cancer Sequencing (pVAC-Seq) that integrates tumor mutation and expression data (DNA- and RNA-Seq). pVAC-Seq is available a

Mid-infrared Variability from the Spitzer Deep Wide-field Survey

We use the multi-epoch, mid-infrared Spitzer Deep Wide-Field Survey to investigate the variability of objects in 8.1 deg^2 of the NOAO Deep Wide Field Survey Boötes field. We perform a Difference Image Analysis of the four available epochs between 2004 and 2008, focusing on the deeper 3.6 and 4.5 μm bands. Out of 474, 179 analyzed sources, 1.1% meet our standard variability selection criteria that the two light curves are strongly correlated (r > 0.8) and that their joint variance (σ_(12)) exceeds that for all sources with the same magnitude by 2σ. We then examine the mid-IR colors of the variable sources and match them with X-ray sources from the XBoötes survey, radio catalogs, 24 μm selected active galactic nucleus (AGN) candidates, and spectroscopically identified AGNs from the AGN and Galaxy Evolution Survey (AGES). Based on their mid-IR colors, most of the variable sources are AGNs (76%), with smaller contributions from stars (11%), galaxies (6%), and unclassified objects, although most of the stellar, galaxy, and unclassified sources are false positives. For our standard selection criteria, 11%-12% of the mid-IR counterparts to X-ray sources, 24 μm AGN candidates, and spectroscopically identified AGNs show variability. The exact fractions depend on both the search depth and the selection criteria. For example, 12% of the 1131 known z>1 AGNs in the field and 14%-17% of the known AGNs with well-measured fluxes in all four Infrared Array Camera bands meet our standard selection criteria. The mid-IR AGN variability can be well described by a single power-law structure function with an index of γ ≈ 0.5 at both 3.6 and 4.5 μm, and an amplitude of S _0 ≃ 0.1 mag on rest-frame timescales of 2 yr. The variability amplitude is higher for shorter rest-frame wavelengths and lower luminosities