The location of innovative activity in Europe

In this paper we use new data to describe how firms from 15 European countries organise their innovative activities. The data matches firm level accounting data with information on the patents that those firms and their subsidiaries have applied for at the European Patents Office. We describe the data in detail

Microresonator-based high-resolution gas spectroscopy

In recent years, microresonator-based optical frequency combs have created up opportunities for developing a spectroscopy laboratory on a chip due to its broadband emission and high comb power. However, with mode spacings typically in the range of 10 - 1000 GHz, the realization of a chip-based high-resolution spectrometer suitable for gas-phase spectroscopy has proven to be difficult. Here, we show mode-hop-free tuning of a microresonator-based frequency comb over 16 GHz by simultaneously tuning both the pump laser and the cavity resonance. We illustrate the power of this scanning technique by demonstrating gas-phase molecular fingerprinting of acetylene with a high-spectral-resolution of < 80 MHz over a 45-THz optical bandwidth in the mid-IR. Our technique represents a significant step towards on-chip gas sensing with an ultimate spectral resolution given by the comb linewidth

WISE J163940.83-684738.6: A Y Dwarf identified by Methane Imaging

We have used methane imaging techniques to identify the near-infrared counterpart of the bright WISE source WISEJ163940.83-684738.6. The large proper motion of this source (around 3.0arcsec/yr) has moved it, since its original WISE identification, very close to a much brighter background star -- it currently lies within 1.5" of the J=14.90+-0.04 star 2MASS16394085-6847446. Observations in good seeing conditions using methane sensitive filters in the near-infrared J-band with the FourStar instrument on the Magellan 6.5m Baade telescope, however, have enabled us to detect a near-infrared counterpart. We have defined a photometric system for use with the FourStar J2 and J3 filters, and this photometry indicates strong methane absorption, which unequivocally identifies it as the source of the WISE flux. Using these imaging observations we were then able to steer this object down the slit of the FIRE spectrograph on a night of 0.6" seeing, and so obtain near-infrared spectroscopy confirming a Y0-Y0.5 spectral type. This is in line with the object's near-infrared-to-WISE J3--W2 colour. Preliminary astrometry using both WISE and FourStar data indicates a distance of 5.0+-0.5pc and a substantial tangential velocity of 73+-8km/s. WISEJ163940.83-684738.6 is the brightest confirmed Y dwarf in the WISE W2 passband and its distance measurement places it amongst the lowest luminosity sources detected to date.Comment: Accepted for publication in The Astrophysical Journal, 20 September 201

EPR studies of manganese centers in SrTiO3: Non-Kramers Mn3+ ions and spin-spin coupled Mn4+ dimers

X- and Q-band electron paramagnetic resonance (EPR) study is reported on the SrTiO3 single crystals doped with 0.5-at.% MnO. EPR spectra originating from the S = 2 ground state of Mn3+ ions are shown to belong to the three distinct types of Jahn-Teller centres. The ordering of the oxygen vacancies due to the reduction treatment of the samples and consequent formation of oxygen vacancy associated Mn3+ centres are explained in terms of the localized charge compensation. The EPR spectra of SrTiO3: Mn crystals show the presence of next nearest neighbor exchange coupled Mn4+ pairs in the directions.Comment: 17 pages, 8 figure

A second order minimality condition for the Mumford-Shah functional

A new necessary minimality condition for the Mumford-Shah functional is derived by means of second order variations. It is expressed in terms of a sign condition for a nonlocal quadratic form on $H^1_0(\Gamma)$, $\Gamma$ being a submanifold of the regular part of the discontinuity set of the critical point. Two equivalent formulations are provided: one in terms of the first eigenvalue of a suitable compact operator, the other involving a sort of nonlocal capacity of $\Gamma$. A sufficient condition for minimality is also deduced. Finally, an explicit example is discussed, where a complete characterization of the domains where the second variation is nonnegative can be given.Comment: 30 page

A Preliminary Report on Unique Hail and Tornadic Storm Observations in Central Illinois and Eastern Indiana on 3 April 1974

published or submitted for publicationis peer reviewedOpe

In vitro models for liver toxicity testing

Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, immortalized cell lines, and primary hepatocytes have been used extensively. Immortalized cell lines and primary isolated liver cells are currently the most widely used in vitro models for liver toxicity testing. Limited throughput, loss of viability, and decreases in liver-specific functionality and gene expression are common shortcomings of these models. Recent developments in the field of in vitro hepatotoxicity include three-dimensional tissue constructs and bioartificial livers, co-cultures of various cell types with hepatocytes, and differentiation of stem cells into hepatic lineage-like cells. In an attempt to provide a more physiological environment for cultured liver cells, some of the novel cell culture systems incorporate fluid flow, micro-circulation, and other forms of organotypic microenvironments. Co-cultures aim to preserve liver-specific morphology and functionality beyond those provided by cultures of pure parenchymal cells. Stem cells, both embryonic- and adult tissue-derived, may provide a limitless supply of hepatocytes from multiple individuals to improve reproducibility and enable testing of the individual-specific toxicity. This review describes various traditional and novel in vitro liver models and provides a perspective on the challenges and opportunities afforded by each individual test system.National Institutes of Health (U.S.) (P42 ES005948)National Institutes of Health (U.S.) (R01 ES01524