15 research outputs found
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
- Ali Sonia
- Allen Hana Lango
- Allen Louise
- Allsup David
- Alvi Mohsan
- Ambegaonkar Gautum
- Ambridge Kirsty
- Anderson Carl
- Anderson Julie
- Anjum Uruj
- Anney Richard
- Antony Dinu
- Antrobus Richard
- Archer Hayley
- Armstrong Ruth
- Armstrong Ruth
- Arno Gavin
- Artigas Maria Soler
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Awada Jana
- Ayub Muhammad
- Bacchelli Chiara
- Bakchoul Tamam
- Balasubramaniam Senduran
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Bariana Tadbir K.
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barroso Inês
- Batstone Paul
- Baty David
- Baxendale Helen
- Bayzetinova Tanya
- Beales Phil
- Bennett Chris
- Bennett David
- Bentham Jamie
- Berg Jonathan
- Bernhard Birgitta
- Bethune Claire
- Bevan A. Paul
- Bhattacharya Shoumo
- Bibi Shahnaz
- Birney Ewan
- Bitner-Glindzicz Maria
- Bitner-Glindzicz Maria
- Blackwood Douglas
- Blair Edward
- Bleda Marta
- Blyth Moira
- Bobrow Martin
- Bochukova Elena
- Boggard Harm
- Bohanna David
- Bolton Patrick
- Bolton-Maggs Paula
- Booth Claire
- Bounds Rebecca
- Bourdon Louise
- Bourn David
- Boustred Chris
- Bradley John R.
- Bradley Lisa
- Brady Angela
- Brady Angie
- Breen Gerome
- Brent Simon
- Brewer Carole
- Brown Matthew
- Browning Michael
- Brunstrom Kate
- Bryant Emily
- Bryson Christine
- Bunyan David J.
- Burn John
- Burns Siobhan
- Calissano Mattia
- Calleja Paul
- Canham Natalie
- Canham Natalie
- Carmichael Jenny
- Carss Keren
- Carss Keren
- Carss Keren J.
- Carvill Gemma L.
- Castle Bruce
- Caulfield Mark
- Chalmers Elizabeth
- Chandler Kate
- Chandra Anita
- Chatterjee Krishna
- Chatzimichali Elena
- Chen Lu
- Chinnery Patrick
- Chitre Manali
- Church Colin
- Ciampi Antonio
- Cilliers Deirdre
- Cirak Sebhattin
- Clapham Peter
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clayton-Smith Jill
- Clement Emma
- Clement Gail
- Clements-Brod Naomi
- Clowes Virginia
- Clowes Virginia
- Coates Andrea
- Coates Guy
- Coghlan Gerry
- Cole Trevor
- Colgiu Irina
- Collier David
- Collins Amanda
- Collins Peter
- Collinson Morag N.
- Connell Fiona
- Cooper Nichola
- Cooper Nicola
- Cosgrove Catherine
- Cox Helen
- Cox Tony
- Craddock Nick
- Creaser-Myers Amanda
- Cresswell Lara
- Crooks Lucy
- Cross Gareth
- Cross J. Helen
- Crow Yanick
- Curran Sarah
- Curtis David
- D?Alessandro Mariella
- Dabir Tabib
- DaCosta Rosa
- Daly Allan
- Daugherty Louise
- Davidson Rosemarie
- Davies Sally
- Davies Sophie
- Davis John
- Day Ian N.M.
- Day-Williams Aaron
- de Vries Dylan
- De Vries Minka
- Dean John
- Debelle Geoff D.
- Deegan Patrick
- Deevi Sri V.V.
- Deshpande Charu
- Deshpande Charu
- Devlin Gemma
- Devlin Lisa
- Dewhurst Eleanor
- Dixit Abhijit
- Dobbie Angus
- Doffinger Rainer
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Dormand Natalie
- Douglas Angela
- Douzgou Sofia
- Down Thomas
- Drewe Elizabeth
- Du Yuanping
- Duncan Alexis
- Dunham Ian
- Eason Jacqueline
- Edgar David
- Edkins Sarah
- Egner William
- Ellard Sian
- Ellis Ian
- Ellis Peter
- Elmslie Frances
- Erber Wendy N.
- Erwood Marie
- Evans David
- Evans Karenza
- Everest Sarah
- Everington Tamara
- Faroogi Sadaf
- Fatemifar Ghazaleh
- Favier Remi
- Fendick Tina
- Firth Helen
- Firth Helen V.
- Fisher Richard
- Fitzgerald Tomas W.
- FitzPatrick David R.
- Fitzpatrick David R.
- Fletcher Debra
- Flicek Paul
- Flinter Frances
- Flinter Frances
- Flyod James
- Foley A. Reghan
- Foulds Nicola
- Fox James C.
- Franklin Christopher S.
- Frary Amy
- Freson Kathleen
- Fry Andrew
- Fryer Alan
- Furie Bruce
- Furnell Abigail
- Futema Marta
- Gale Daniel
- Gallagher Louise
- Gardham Alice
- Gardiner Carol
- Gattens Michael
- Gaunt Lorraine
- Geihs Matthias
- Geschwind Daniel
- Ghali Neeti
- Ghali Neeti
- Ghataorhe Pavandeep K.
- Ghurye Rohit
- Gibbons Richard
- Gibbs Simon
- Gill Harinder
- Gilmour Kimberley
- Gissen Paul
- Goddard Sarah
- Gomez Keith
- Goodship Judith
- Gordins Pavel
- Gorman Kathleen M.
- Goudie David
- Gray Emma
- Green Andrew
- Greene Daniel
- Greene Philip
- Greenhalgh Alan
- Greenhalgh Lynn
- Greinacher Andreas
- Gribble Susan
- Griffin Heather
- Grigoriadou Sofia
- Grozeva Detelina
- Gräf Stefan
- Guo Xiaosen
- Guo Xueqin
- Gurling Hugh
- Haack Tobias B.
- Hackett Scott
- Hadinnapola Charaka
- Hague Rosie
- Haimel Matthias
- Halmagyi Csaba
- Hammerton Tracey
- Harrison Lucy
- Harrison Rachel
- Harrison Victoria
- Hart Daniel
- Hart Deborah
- Hawkins Rose
- Hayman Grant
- He Liu
- Heemskerk Johan W.M.
- Hellens Stephen
- Henderson Alex
- Henderson Robert
- Hendricks Audrey
- Hensiek Anke
- Henskens Yvonne
- Herwadkar Archana
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
- Holden Simon
- Holder Muriel
- Holder Muriel
- Holder Susan
- Holder Susan
- Hollingsworth Georgina
- Holmans Peter
- Homfray Tessa
- Howie Bryan
- Hu Fengyuan
- Huang Liren
- Hubbard Tim
- Huissoon Aarnoud
- Humbert Marc
- Humphreys Mervyn
- Humphries Steve E.
- Hurles Matthew E.
- Hurles Matthew E.
- Hurst Jane
- Hurst Jane
- Hutton Ben
- Hysi Pirro
- Ingram Stuart
- Iotchkova Valentina
- Irving Melita
- Islam Lily
- Jackson Andrew
- Jackson David K.
- James Roger
- Jamshidi Yalda
- Jan-Kamsteeg Eric
- Jarvis Joanna
- Jenkins Lucy
- Jing Tian
- Johnson Diana
- Jolles Stephen
- Jones Elizabeth
- Jones Philip
- Jones Wendy D.
- Josifova Dragana
- Josifova Dragana
- Joss Shelagh
- Joyce Chris
- Kaemba Beckie
- Kaplanis Joanna
- Kaye Jane
- Kazembe Sandra
- Kazmi Rashid
- Keane Thomas
- Keeling David
- Kelleher Peter
- Kelly Anne M.
- Kelsell Rosemary
- Kemp John
- Kennedy Fiona
- Kennedy Karen
- Keogh Julia
- Kerr Bronwyn
- Kiely David
- King Daniel
- King Mary D.
- Kingston Helen
- Kingston Nathalie
- Kini Usha
- Kinning Esther
- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kolb-Kokocinski Anja
- Koziell Ania
- Kraus Alison
- Krishnakumar Deepa
- Krishnappa Netravathi
- Kuijpers Taco W.
- Kumar Dhavendra
- Kumar V. K. Ajith
- Kumararatne Dinakantha
- Kurian Manju
- Kurian Manju A.
- Lachance Genevieve
- Lachlan Katherine
- Laffan Michael A.
- Lam Wayne
- Lambert Michele P.
- Lampe Anne
- Langford Cordelia
- Langman Caroline
- Lawrie Allan
- Lawson Daniel
- Lear Sara
- Lee Irene
- Lees Melissa
- Lees Melissa
- Lek Monkol
- Lentaigne Claire
- Li Rui
- Li Yingrui
- Liang Jieqin
- Liesner Ri
- Lim Derek
- Lin Hong
- Linger Rachel
- Liu Ryan
- Longhurst Hilary
- Longman Cheryl
- Lopes Margarida
- Lorenzo Lorena
- Lowther Gordon
- Lynch Sally A.
- Lönnqvist Jouko
- MacArthur Daniel
- Machado Rajiv
- Mackenzie Rob
- MacLaren Robert
- Magee Alex
- Maher Eamonn
- Maher Eamonn R.
- Maher Eddy
- Maimaris Jesmeen
- Male Alison
- Mangles Sarah
- Manson Ania
- Mansour Sahar
- Mapeta Rutendo
- Marchini Jonathan
- Marenne Gaëlle
- Marks Karen
- Markus Hugh S.
- Martin Jennifer
- Martin Katherine
- Masati Larahmie
- Maslen John
- Mason Laura E.
- Massimo Mangino
- Mathias Mary
- Mathieson Iain
- Matser Vera
- Maw Anna
- Maye Una
- McCann Emma
- McConnell Vivienne
- McCullagh Gary
- McDermott Elizabeth
- McEntagart Meriel
- McGowan Ruth
- McGuffin Peter
- McIntosh Andrew
- McJannet Coleen
- McKay Kirsten
- McKechanie Andrew G.
- McKee Shane
- McMullan Dominic J.
- McNerlan Susan
- McQuillin Andrew
- McRae Jeremy F.
- McTague Amy
- McWilliam Catherine
- Meacham Stuart
- Meehan Sharon
- Mefford Heather C.
- Megy Karyn
- Mehta Sarju
- Mehta Sarju
- Metcalfe Kay
- Metrustry Sarah
- Meyer Esther
- Michaelides Michel
- Middleton Anna
- Miedzybrodzka Zosia
- Miles Emma
- Millar Carolyn M.
- Millichap John J.
- Mitchison Hannah
- Moayyeri Alireza
- Mohammed Shehla
- Moledina Shahin
- Montgomery Tara
- Moore Anthony
- Moore David
- Morgan Sian
- Morrell Nicholas
- Morris James
- Morton Jenny
- Morton Jenny
- Mugalaasi Hood
- Mumford Andrew
- Muntoni Francesco
- Murday Victoria
- Murng Sai
- Murphy Elaine
- Murphy Helen
- Naik Swati
- Nejentsev Sergey
- Nellåker Chris
- Nemeth Andrea
- Nevitt Louise
- Newbury-Ecob Ruth
- Noorani Sadia
- Norman Andrew
- Northstone Kate
- Nurden Paquita
- O'Donovan Michael
- O'Rahilly Stephen
- O'Shea Rosie
- Ogilvie Caroline
- Oksenhendler Eric
- Ong Kai-Ren
- Onoufriadis Alexandros
- Oualkacha Karim
- Ouwehand Willem H.
- Owen Michael J.
- Paciorkowski Alex R.
- Palotie Aarno
- Panoutsopoulou Kalliope
- Papadia Sofia
- Park Soo-Mi
- Park Soo-Mi
- Parker Alasdair
- Parker Michael
- Parker Michael J.
- Parker Victoria
- Parr Jeremy R.
- Pasi John
- Patch Chris
- Patel Chirag
- Paternoster Lavinia
- Paterson Joan
- Paterson Joan
- Paunio Tiina
- Payne Felicity
- Payne Jeanette
- Payne Stewart
- Peacock Andrew
- Peerlinck Kathelijne
- Penkett Christopher J.
- Pepke-Zaba Joanna
- Perrett Daniel
- Perry David J.
- Phipps Julie
- Pietilainen Olli
- Pilz Daniela T.
- Plagnol Vincent
- Poduri Annapurna
- Pollard Martin
- Pollock Val
- Polwarth Gary
- Ponsford Mark
- Pottinger Caroline
- Poulton Joanna
- Pratt Norman
- Prescott Katrina
- Pressler Ronit M.
- Price Sue
- Pridham Abigail
- Prigmore Elena
- Procter Annie
- Purnell Hellen
- Qasim Waseem
- Quail Michael A.
- Quarrell Oliver
- Quaye Lydia
- Quinti Isabella
- Ragge Nicola
- Rahbari Raheleh
- Rajan Diana
- Randall Josh
- Rankin Julia
- Rankin Julia
- Rankin Stuart
- Raymond F. Lucy
- Raymond F. Lucy
- Raymond Lucy
- Raymond Lucy
- Rehnstrom Karola
- Rehnström Karola
- Reich Adi
- Reid Evan
- Rhodes Christopher J.
- Rice Debbie
- Richards Michael
- Richardson Sylvia
- Richter Alex
- Ring Susan
- Ritchie Graham R.S.
- Robert Leema
- Roberts Eileen
- Roberts Gillian
- Roberts Irene
- Roberts Jonathan
- Roberts Nicola
- Roberts Paul
- Rondina Matthew
- Ross Alison
- Rosser Elisabeth
- Rosser Elisabeth
- Roughley Catherine
- Rue-Albrecht Kevin
- Saggar Anand
- Samant Shalaka
- Samarghitean Crina
- Sampson Julian
- Sanchis-Juan Alba
- Sanchis-Juan Alba
- Sandford Richard
- Sandford Richard
- Santra Saikat
- Sargur Ravishankar
- Sarkar Ajoy
- Savage David B.
- Savic Sinisa
- Scambler Peter
- Scheffer Ingrid E.
- Schiffels Stephen
- Schmidts Miriam
- Schneider Amy L.
- Schoenmakers Nadia
- Schulman Sol
- Schulze Harald
- Schweiger Susann
- Scott Richard
- Scott Richard
- Scully Marie
- Scurr Ingrid
- Selby Ann
- Seller Anneke
- Semple Robert K.
- Seneviratne Suranjith
- Sequeira Cheryl
- Serra Eva
- Sewell Carrock
- Shamardina Olga
- Shannon Nora
- Sharif Saba
- Sharp Sally I.
- Shaw-Smith Charles
- Shearing Emma
- Shears Debbie
- Sheridan Eamonn
- Shin So-Youn
- Shipley Debbie
- Sieciechowicz Diana
- Sifrim Alejandro
- Simeoni Ilenia
- Simonic Ingrid
- Simpson Michael A.
- Singh Tarjinder
- Singzon Roldan
- Sivapalaratnam Suthesh
- Skitt Zara
- Skuse David
- Small Kerrin
- Smith Audrey
- Smith Kath
- Smith Kenneth
- Smithson Sarah
- Sneddon Linda
- Sohal Aman
- Southam Lorraine
- Southgate Laura
- Spasic-Boskovic Olivera
- Spinelli Egidio
- Splitt Miranda
- Squires Miranda
- St Clair David
- St Pourcian Beate
- Staines Simon
- Stalker Jim
- Staples Emily
- Stauss Hans
- Stein Penelope
- Stephens Jonathan
- Stevens Elizabeth
- Stewart Fiona
- Stewart Helen
- Stirrups Kathleen
- Stock Sophie
- Straub Volker
- Sun Jianping
- Suntharalingam Jay
- Suri Mohnish
- Sutton Vivienne
- Suvisaari Jaana
- Swaminathan Ganesh Jawahar
- Sweeney Elizabeth
- Tachmazidou Ionna
- Tait R. Campbell
- Talks Kate
- Tan Yvonne
- Tatton-Brown Kate
- Taylor Cat
- Taylor Rohan
- Tein Mark
- Temple I. Karen
- Thachil Jecko
- Thaventhiran James
- Thomas Ellen
- Thomas Moira
- Thompson Dorothy
- Thomson Jenny
- Thrasher Adrian
- Tischkowitz Marc
- Tischkowitz Marc
- Titterton Catherine
- Tivey Adrian R.
- Tobin Martin D.
- Toh Cheng-Hock
- Tomkins Susan
- Torokwa Audrey
- Toshner Mark
- Treacy Becky
- Treacy Carmen
- Trembath Richard
- Tuna Salih
- Turek Wojciech
- Turner Claire
- Turnpenny Peter
- Turro Ernest
- Tysoe Carolyn
- Valdes Ana
- Van Geet Chris
- Van Kogelenberg Margriet
- Vandersteen Anthony
- Varghese Vinod
- Vasudevan Pradeep
- Veltman Marijke
- Vijayarangakannan Parthiban
- Vijayarangakannan Parthiban
- Visscher Peter M.
- Vogt Julie
- Vogt Julie
- von Ziegenweldt Julie
- Vonk Noordegraaf Anton
- Wain Louise V.
- Wakeling Emma
- Wakeling Emma
- Wallwark Sarah
- Walters James T.R.
- Wang Guangbiao
- Wang Jun
- Wang Yu
- Wanjiku Ivy
- Ward Kirsten
- Warner Timothy Q.
- Wassmer Evangeline
- Wassmer Evangeline
- Waters Jonathon
- Watkins Hugh
- Weber Astrid
- Webster Andrew
- Welch Steve
- Wellesley Diana
- Westbury Sarah
- Wharton John
- Wheeler Elanor
- Whiteford Margo
- Whitehorn Deborah
- Whyte Tamieka
- Widaa Sara
- Wilcox Sarah
- Wilkins Martin
- Wilkinson Emily
- Willcocks Lisa
- Williams Denise
- Williams Hywel
- Williams Nicola
- Williamson Catherine
- Williamson Kathleen A.
- Wilson Crispian
- Wilson Louise
- Wong Kim
- Woods Geoff
- Woods Geoffrey
- Wort John
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
Resistant starch does not affect zinc homeostasis in rural Malawian children
- Author
- Assisi
- Bird
- Bird
- Black
- Brown
- Champ
- Chrissie Thakwalakwa
- Claire Westcott
- Conlon
- Davies
- de Benoist
- Elissa Mortimer
- Ferguson
- Fischer Walker
- Friel
- Graeme Young
- Griffin
- Griffin
- Ha Aw Han
- Hambidge
- Hambidge
- Institute of Medicine
- International Zinc Nutrition Consultative Group
- Jamie Westcott
- K. Michael Hambidge
- Kelsey Ryan
- Ken Maleta
- Krebs
- Le Thanh-Blicharz
- Leland V. Miller
- M. Isabel Ordiz
- Manary
- Manary
- Manary
- Mark J. Manary
- McCleary
- McCleary
- Miller
- Morita
- Nancy F. Krebs
- O’Dell
- Prasad
- Sharma
- Sheng
- Sheng
- Sian
- Thaddaeus May
- Thakwalakwa
- Trinder
- Viveros
- World Health Organization
- Yonekura
- Zhu
- Zinc Investigators’ Collaborative Group
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The role of astrocytes in parkinson\u27s disease
- Author
- A Norazit
- A Schober
- A Widestrand
- AB Smit
- B Mirza
- B Stevens
- B Stevens
- B Wachter
- BJ Jin
- BZ Barkho
- C Farina
- C Iacovetta
- C Iadecola
- C Knott
- C Lecrux
- CJ Garwood
- D Nagy
- D Rossi
- D Schiffer
- DC Lie
- DH Mauch
- DJ Gelb
- DJ Selkoe
- DV Dabir
- DW Dickson
- E Colombo
- EM Ullian
- GJ Michael
- GM Halliday
- GR Gordon
- H Braak
- H Funato
- H Song
- HH Fernandez
- HJ Lee
- HM Wisniewski
- I Allaman
- I Choi
- J Hu
- J Jin
- J Liauw
- J Sian
- J Waak
- JD Warren
- JH Kim
- JH Power
- JM Taylor
- JS Jung
- JW Langston
- JZ Chuang
- K Becker
- K Ikeda
- K Nagler
- K Sathe
- K Sekiyama
- K Tanaka
- KA Jellinger
- KL Double
- KS Christopherson
- L Wang
- LF Eng
- LK Kwong
- M Iino
- M Inden
- M Lu
- M Tolnay
- M Zarate-Lagunes
- MC Marchetto
- MD Ledesma
- MG Schlossmacher
- ML Kashon
- MS Forman
- MV Sofroniew
- MY Inyushin
- N Braidy
- N Futakawa
- N Kimura
- N Lev
- NA Oberheim
- NJ Maragakis
- PD Kushner
- PF Durrenberger
- PH Gordon
- R Bandopadhyay
- R Betarbet
- R Kinouchi
- R Niranjan
- RB Mythri
- S Gandhi
- S Gilman
- S Schmidt
- SC Papasozomenos
- SH Oliet
- SJ Mullett
- T Komori
- T Murakami
- T Nomura
- TB Sherer
- TD Papkovskaia
- TG Beach
- U Wilhelmsson
- V Menet
- W Matsunaga
- WC Risher
- WL Lin
- WS Griffin
- XL Gu
- Y Li
- YJ Song
- Publication venue
- 'Sociological Research Online'
- Publication date
- 01/01/2014
- Field of study
2014 Springer International Publishing Switzerland. All rights reserved. Unlike other disorders, astrocytes in regions undergoing neurodegeneration in patients with Parkinson\u27s disease do not become reactive. Instead gray matter protoplasmic astrocytes accumulate α-synuclein, withdraw their processes from damaged neurons, and show altered expression of constituent proteins, including PINK-1, parkin, and DJ-1 (gene products associated with recessive Parkinson\u27s disease). These and other gene products are normally up-regulated in astrocytes by disease states. Combined, these data suggest that protoplasmic astrocytes lose their protective function in patients with Parkinson\u27s disease, leaving neurons vulnerable to perturbations and insults they would normally be protected from. Recent work also shows that astrocytes are able to take up and metabolize L-DOPA, the drug of choice for standard therapy for Parkinson\u27s disease. It is therefore possible that ongoing astrocytic dysfunction may compromise the efficacy of L-DOPA therapy. These unique astrocytic responses to the disease process and current main therapy support the concept that astrocytes play a critical, under-recognized role in the initiation, progression, and treatment response of patients with Parkinson\u27s disease
The Role of Astrocytes in Parkinson’s Disease
- Author
- A Norazit
- A Schober
- A Widestrand
- AB Smit
- B Mirza
- B Stevens
- B Stevens
- B Wachter
- BJ Jin
- BZ Barkho
- C Farina
- C Iacovetta
- C Iadecola
- C Knott
- C Lecrux
- CJ Garwood
- D Nagy
- D Rossi
- D Schiffer
- DC Lie
- DH Mauch
- DJ Gelb
- DJ Selkoe
- DV Dabir
- DW Dickson
- E Colombo
- EM Ullian
- GJ Michael
- GM Halliday
- GR Gordon
- H Braak
- H Funato
- H Song
- HH Fernandez
- HJ Lee
- HM Wisniewski
- I Allaman
- I Choi
- J Hu
- J Jin
- J Liauw
- J Sian
- J Waak
- JD Warren
- JH Kim
- JH Power
- JM Taylor
- JS Jung
- JW Langston
- JZ Chuang
- K Becker
- K Ikeda
- K Nagler
- K Sathe
- K Sekiyama
- K Tanaka
- KA Jellinger
- KL Double
- KS Christopherson
- L Wang
- LF Eng
- LK Kwong
- M Iino
- M Inden
- M Lu
- M Tolnay
- M Zarate-Lagunes
- MC Marchetto
- MD Ledesma
- MG Schlossmacher
- ML Kashon
- MS Forman
- MV Sofroniew
- MY Inyushin
- N Braidy
- N Futakawa
- N Kimura
- N Lev
- NA Oberheim
- NJ Maragakis
- PD Kushner
- PF Durrenberger
- PH Gordon
- R Bandopadhyay
- R Betarbet
- R Kinouchi
- R Niranjan
- RB Mythri
- S Gandhi
- S Gilman
- S Schmidt
- SC Papasozomenos
- SH Oliet
- SJ Mullett
- T Komori
- T Murakami
- T Nomura
- TB Sherer
- TD Papkovskaia
- TG Beach
- U Wilhelmsson
- V Menet
- W Matsunaga
- WC Risher
- WL Lin
- WS Griffin
- XL Gu
- Y Li
- YJ Song
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study
- Author
- Abreu Marcelo Gama de
- Adderly Jane
- Aguirre Stefania
- Akgun Nur
- Alberts Erna
- Alzugaray Pedro
- Anquez Nathalie
- Anstey James
- Artigas-Raventós Antonio
- Artigas-Raventós Antonio
- Avendaño Rossana
- Aydin Demet
- Aytulun Akut
- Bacuzzi Alessandro
- Bahl Marina
- Barbas Carmen S V
- Barbas Carmen S V
- Barcraft-Barnes Helena
- Barrell Lisa
- Beavis Sarah
- Bell Adam
- Bell Stephanie
- Bentley Andrew
- Beraldo Daniel
- Bewley Jeremy
- Biondi Rodrigo
- Birch Sian
- Blaylock Heather
- Blenk Karl
- Botteri Marco
- Bourgeois Marc
- Boyd Christine
- Boyd Owen
- Brazier Melinda
- Brazzi Luca
- Brohi Farooq
- Brown Carly
- Bullock Clare
- Burt Karen
- Buyukkocak Unase
- Bynorth Natalie
- Caione Raffaele
- Camsooksai Julie
- Canet Jaume
- Canet Jaume
- Carnahan Mandy
- Carreño Nicolás
- Caser Eliane Bernadete
- Cavalcanti Alexandre Biasi
- Ceunen Helga
- Chan Alexandre
- Chenna Shailaja
- Cinnella Gilda
- Cirstea Emanuel
- Clarkson Kevin
- Clifford Gayle
- Collins Daniel
- Cooper Jonathan
- Cooper Lucy
- Corner Andrew
- Cortegiani Andrea
- Cowton Amanda
- Creagh-Brown Ben
- Criswell John
- Crowther Hannah
- D'Antini Davide
- da Silva Ramos Fernando José
- Dark Paulo
- de Abreu Marcelo Gama
- DeCrop Luc
- Decruyenaere Johan
- Demirtürk Zerrin
- Denker Ahmet Sukru
- Determann Rogier M
- Determann Rogier M
- Devile Michael
- Dilek Ahmet
- Dixon Barry
- Dogan Nazim
- Donaldson Denise
- dos Santos Moreno Calcagnotto
- Downes Charlotte
- Dvorscak Matea Bogdanovic
- Ekinci Osman
- Eren Gulay
- Evans Tracey
- Everett Lynn
- Falcão Luis Fernando
- Fasting Lousie
- Faulkner Maria
- Fisher Nicola
- Fitzell Pauline
- Frey Christian
- Furneval Julie
- Gava Isabela Ambrósio
- Gecaj-Gashi Agreta
- Ghosh Alison
- Giles Julian
- Gill Pardeep
- Glenn Sue
- Goktas Ugur
- Gopal Shammer
- Green Helen
- Griffin Dawn Trodd Denise
- Grimmer Lisa
- Hadfield Daniel
- Harris Clair
- Harris Meredith
- Harrison Jonathan
- Hatton Tom
- Hedenstierna Goran
- Hedenstierna Goran
- Hemmes Sabrine N T
- Hemmes Sabrine N T
- Hendry Sam
- Hermans Greet
- Hermans Greet
- Hermans Greet
- Hiesmayr Michael
- Hiesmayr Michael
- Hollands Robin
- Holliday Mark
- Hollister Nigel
- Hollmann Markus W
- Hollmann Markus W
- Hopkins Phil
- Hormis Anil
- Howard-Griffin Richard
- Howe Joanne
- Hughes Chloe
- Hugill Keith
- Hull Daniel
- Humphries Ryan
- Huneke Nathan
- Hunt Jane
- Jaafar Rola
- Jaber Samir
- Jaber Samir
- Jacob Reni
- James Shanaz
- Janes Stephanie
- Joyce Kristen
- Jurjevic Matija
- Kahveci Feda
- Kaloo Claire
- Karanovic Nenad
- Kienbaum Peter
- Klaric Vlasta
- Knighton John
- Kol Mark
- Koopmans Matty
- Kose Isil
- Kozlowski Marta
- Kratochvil Milan
- Krkusek Marijana
- Kuiper Michael
- Lakhani Sandeep
- Lamb Nicola
- Lauro Eduardo Di
- Leaver Susannah
- Limb James
- Linnett Vanessa
- Lynch Katie
- MacNaughton Peter
- Macruz Tiago
- Maia Israel
- Martin Jane
- Martin-Loeches Ignacio
- Martin-Loeches Ignacio
- Matsa Ramprasad
- Matthews Claire
- Matthews Kelly
- Máca Jan
- McCullagh Iain
- McInerney Amy
- Mecatti Giovana Colozza
- Melbourne Susan
- Melchionda Giuseppe
- Mellinghoff Johannes
- Mellis Clare
- Melo Marcos F V
- Melo Marcos F Vidal
- Melo Marcos F Vidal
- Mestria Donatella
- Metherell Stella
- Miller Claire
- Mills Gary H
- Mills Gary H
- Mills Gary H
- Mirabella Lucia
- Molin Alexandre
- Montgomery Jane
- Morales Mauricio
- Moreton Sarah
- Mouland Johanna
- Muench Christoph
- Munhoz Carlos
- Murray Lorna
- Needleman Joseph
- Neto Ary Serpa
- Neto Ary Serpa
- Niska Lotta
- Oliveira Vanessa
- Oliver Rebecca
- Orak Yavuz
- Ortiz-Ruiz Laura
- Özcan Perihan Ergin
- Paddle Jonathan
- Padilla-Harris Cheryl
- Parris Michael
- Patel Tasmin
- Pearse Rupert M
- Pearse Rupert M
- Pearson Rachel
- Pearson Sallyane
- Peçanha Ana Carolina
- Pegg Claire
- Pellegrini Jose Augusto Santos
- Pelosi Paolo
- Peluso Lorenzo
- Pinder Angela
- Pinto Sérgio Felix
- Piras Claudio
- Plant Robert
- Plowright Catherine
- Pogson David
- Poultney Una
- Prado Daniel
- Preller Kobus
- Prudden Sarah
- Pulak Paul
- Pulletz Mark
- Putensen Christian
- Putensen Christian
- Raimondo Pasquale
- Ramali Mohamed
- Reed Isabelle
- Reschreiter Henrik
- Ritzema Jenny
- Robertson Helen
- Rodgers Helen
- Rogerson David
- Romano Marcelo Luz Pereira
- Rose Alastair
- Rose Steve
- Roy Alistair
- Ruas Kessia
- Russotto Vincenzo
- Ryan Christine
- Sales Gabriele
- Salgado Jean
- Salt Ruth
- Santos Cristina
- Santos Rafaella Souza dos
- Saylan Sedat
- Schaefer Maximilian
- Schlegel Christian
- Schmid Werner
- Schmid Werner
- Schultz Marcus J
- Schultz Marcus J
- Schultz Marcus J
- Scott Carmen
- Seasman Colette
- Seghelini Elisa
- Senturk Evren
- Severgnini Paolo
- Sewell Terri-Ann
- Sharman Michael
- Shaw David
- Simeson Karen
- Simonis Fabienne D
- Simonis Fabienne D
- Simurina Tatjana
- Skilijic Sonja
- Skinner Amanda
- Smalley Christopher
- Smith Deborah
- Smith Roger
- Smith Roger
- Smith Roger
- Snell Jane
- Soyoral Lokman
- Spadaro Savino
- Spencer Hazel
- Sribar Andrej
- Stickley Johanna
- Stourac Petr
- Suresh Sheeba
- Sweet Katie
- Talbot Helen
- Tarmey Nicholas
- Tbaily Lee
- Thornthwaite Sarah
- Toman Huseyin
- Toms Julie
- Tonks Louise
- Treschan Tanja A
- Treschan Tanja A
- Treschan Tanja A
- Tschernko Edda M
- Tschernko Edda M
- Tuinman Pieter Roel
- Turan Güldem
- Turner Kate
- Tyson Susan
- Ulger Fatma
- Ulusoy Hulya
- van den Hul Ingrid
- Van Haren Frank
- Venner Nicola
- Verrastro Pasquale
- Volta Carlo Alberto
- Walker Anna
- Walker Rachel
- Watters Malcolm
- Weller Debbie
- Welters Ingeborg
- Whileman Amanda
- White Ian
- Wilde Robert BP de
- Williams Karen
- Wilson Deborah
- Wilson Natalie
- Windebank Steve
- Wong Helen
- Wreybrown Caroline
- Wrigge Hermann
- Wrigge Hermann
- Wrigge Hermann
- Wright Stephen
- Youds Laura
- Young Eoin
- Zincircioglu Çiler
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Background Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS. Methods PRoVENT (PRactice of VENTilation in critically ill patients without ARDS at onset of ventilation) is an international, multicentre, prospective study undertaken at 119 ICUs in 16 countries worldwide. All patients aged 18 years or older who were receiving mechanical ventilation in participating ICUs during a 1-week period between January, 2014, and January, 2015, were enrolled into the study. The Lung Injury Prediction Score (LIPS) was used to stratify risk of ARDS, with a score of 4 or higher defining those at risk of ARDS. The primary outcome was the proportion of patients at risk of ARDS. Secondary outcomes included ventilatory management (including tidal volume [VT] expressed as mL/kg predicted bodyweight [PBW], and positive end-expiratory pressure [PEEP] expressed as cm H2O), development of pulmonary complications, and clinical outcomes. The PRoVENT study is registered at ClinicalTrials.gov, NCT01868321. The study has been completed. Findings Of 3023 patients screened for the study, 935 individuals fulfilled the inclusion criteria. Of these critically ill patients, 282 were at risk of ARDS (30%, 95% CI 27–33), representing 0·14 cases per ICU bed over a 1-week period. VT was similar for patients at risk and not at risk of ARDS (median 7·6 mL/kg PBW [IQR 6·7–9·1] vs 7·9 mL/kg PBW [6·8–9·1]; p=0·346). PEEP was higher in patients at risk of ARDS compared with those not at risk (median 6·0 cm H2O [IQR 5·0–8·0] vs 5·0 cm H2O [5·0–7·0]; p<0·0001). The prevalence of ARDS in patients at risk of ARDS was higher than in individuals not at risk of ARDS (19/260 [7%] vs 17/556 [3%]; p=0·004). Compared with individuals not at risk of ARDS, patients at risk of ARDS had higher in-hospital mortality (86/543 [16%] vs 74/232 [32%]; p<0·0001), ICU mortality (62/533 [12%] vs 66/227 [29%]; p<0·0001), and 90-day mortality (109/653 [17%] vs 88/282 [31%]; p<0·0001). VT did not differ between patients who did and did not develop ARDS (p=0·471 for those at risk of ARDS; p=0·323 for those not at risk). Interpretation Around a third of patients receiving mechanical ventilation in the ICU were at risk of ARDS. Pulmonary complications occur frequently in patients at risk of ARDS and their clinical outcome is worse compared with those not at risk of ARDS. There is potential for improvement in the management of patients without ARDS. Further refinements are needed for prediction of ARDS
Genome-wide physical activity interactions in adiposity:a meta-analysis of 200,452 adults
- Author
- Aadahl M. (Mette)
- Abecasis G. R. (Goncalo R.)
- Adair L. S. (Linda S.)
- Ahluwalia T. S. (Tarunveer S.)
- Ahmad S. (Shafqat)
- Amin N. (Najaf)
- Auvinen J. (Juha)
- Balkau B. (Beverley)
- Bandinelli S. (Stefania)
- Barata L. (Llilda)
- Barroso I. (Ines)
- Beilby J. (John)
- Bellis C. (Claire)
- Bergman R. N. (Richard N.)
- Bergmann S. (Sven)
- Bertoni A. G. (Alain G.)
- Bielak L. F. (Lawrence F.)
- Bien S. (Stephanie)
- Blangero J. (John)
- Boehnke M. (Michael)
- Boerwinkle E. (Eric)
- Bonnefond A. (Amelle)
- Bonnycastle L. L. (Lori L.)
- Boomsma D. I. (Dorret I.)
- Borecki I. B. (Ingrid B.)
- Borja J. B. (Judith B.)
- Bouchard C. (Claude)
- Brage S. (Soren)
- Bragg-Gresham J. L. (Jennifer L.)
- Busonero F. (Fabio)
- Buyske S. (Steve)
- Cadby G. (Gemma)
- Campbell H. (Harry)
- Chambers J. C. (John C.)
- Chasman D. I. (Daniel I.)
- Cheng Y.-C. (Yu-Ching)
- Chines P. S. (Peter S.)
- Chu A. Y. (Audrey Y.)
- Collins F. S. (Francis S.)
- Cornelis M. (Marilyn)
- Corre T. (Tanguy)
- Cucca F. (Francesco)
- Cupples L. A. (L. Adrienne)
- de Geus E. J. (Eco J. C.)
- De Moor M. H. (Marleen H. M.)
- Delgado G. E. (Graciela E.)
- Demirkan A. (Ayse)
- den Hoed M. (Marcel)
- Doerr M. (Marcus)
- Dueker N. (Nicole)
- Ebeling T. (Tapani)
- Eicher J. D. (John D.)
- Eiriksdottir G. (Gudny)
- Eriksson J. (Joel)
- Esko T. (Tonu)
- Faerch K. (Kristine)
- Faul J. D. (Jessica D.)
- Feitosa M. F. (Mary F.)
- Fornage M. (Myriam)
- Fox C. S. (Caroline S.)
- Franks P. W. (Paul W.)
- Frayling T. M. (Timothy M.)
- Froguel P. (Philippe)
- Fu M. (Mao)
- Gieger C. (Christian)
- Glaeser S. (Sven)
- Gong J. (Jian)
- Gordon-Larsen P. (Penny)
- Graff M. (Mariaelisa)
- Grallert H. (Harald)
- Grammer T. B. (Tanja B.)
- Grarup N. (Niels)
- Griffin P. J. (Paula J.)
- Gudnason V. (Vilmundur)
- Gyllensten U. (Ulf)
- Hadley D. (David)
- Haiman C. A. (Christopher A.)
- Haller T. (Toomas)
- Hallmans G. (Goran)
- Hansen T. (Torben)
- Harald K. (Kennet)
- Harder M. N. (Marie Neergaard)
- Harris T. B. (Tamara B.)
- Hartman C. A. (Catharina A.)
- Hassinen M. (Maija)
- Hastie N. D. (Nicholas D.)
- Havulinna A. S. (Aki S.)
- Hayes J. E. (James E.)
- Hayward C. (Caroline)
- Heard-Costa N. L. (Nancy L.)
- Heid I. M. (Iris M.)
- Hernandez D. (Dena)
- Hindorff L. (Lucia)
- Hirschhorn J. N. (Joel N.)
- Hocking L. J. (Lynne J.)
- Hofman A. (Albert)
- Hollensted M. (Mette)
- Holmens O. L. (Oddgeir L.)
- Holzapfel C. (Christina)
- Hottenga J. J. (Jouke Jan)
- Huang J. (Jie)
- Huang T. (Tao)
- Huffman J. E. (Jennifer E.)
- Hui J. (Jennie)
- Huppertz C. (Charlotte)
- Huth C. (Cornelia)
- Hutri-Kahonen N. (Nina)
- Hveem K. (Kristian)
- Jackson A. U. (Anne U.)
- James A. L. (Alan L.)
- Jansson J.-O. (John-Olov)
- Jarvelin M.-R. (Marjo-Riitta)
- Jhun M. A. (Min A.)
- Johansson A. (Asa)
- Johnson A. D. (Andrew D.)
- Juonala M. (Markus)
- Justesen J. M. (Johanne Marie)
- Justice A. E. (Anne E.)
- Kahonen M. (Mika)
- Kardia S. L. (Sharon L. R.)
- Kilpelainen T. O. (Tuomas O.)
- Kinnunen L. (Leena)
- Kivimaki M. (Mika)
- Kleber M. E. (Marcus E.)
- Klein R. J. (Robert J.)
- Koistinen H. A. (Heikki A.)
- Kolcic I. (Ivana)
- Komulainen P. (Pirjo)
- Kooner J. S. (Jaspal S.)
- Kooperberg C. (Charles)
- Kristiansson K. (Kati)
- Kuh D. (Diana)
- Kumari M. (Meena)
- Kutalik Z. (Zoltan)
- Kuusisto J. (Johanna)
- Kvaloy K. (Kirsti)
- Laakso M. (Markku)
- Lakka T. A. (Timo A.)
- Langenberg C. (Claudia)
- Launer L. J. (Lenore J.)
- Lehne B. (Benjamin)
- Lehtimaki T. (Terho)
- Lemarchand L. (Loic)
- Lim E. (Elise)
- Lim U. (Unhee)
- Lindgren C. M. (Cecilia M.)
- Linneberg A. (Allan)
- Liu C.-T. (Ching-Ti)
- Liu Y. (Yongmei)
- Lohman K. (Kurt)
- Loos R. J. (Ruth J. F.)
- Lorentzon M. (Mattias)
- Luan J. (Jian'an)
- Luben R. (Robert)
- Lyytikainen L.-P. (Leo-Pekka)
- Maerz W. (Winfried)
- Magl R. (Reedlk)
- Mahajan A. (Anubha)
- Mangino M. (Massimo)
- Mannikko R. (Reija)
- Mannisto S. (Satu)
- Marques-Vidal P. M. (Pedro M.)
- Marre M. (Michel)
- Marten J. (Jonathan)
- Martin N. G. (Nicholas G.)
- McCarthy M. I. (Mark I.)
- Metspalu A. (Andres)
- Milaneschi Y. (Yuri)
- Mohlke K. L. (Karen L.)
- Monda K. L. (Keri L.)
- Montgomery G. W. (Grant W.)
- Mueller-Nurasyid M. (Martina)
- Mulas A. (Antonella)
- Musk A. W. (A. W.)
- Narisu N. (Narisu)
- Nauck M. (Matthias)
- Navarro P. (Pau)
- Nettleton J. A. (Jennifer A.)
- Ngwa J. S. (Julius S.)
- Nolte I. M. (Ilja M.)
- North K. E. (Kari E.)
- O'Connell J. R. (Jeffrey R.)
- Ohlsson C. (Claes)
- Ohlsson C. (Claes)
- Oldehinkel A. J. (Albertine J.)
- Olden M. (Matthias)
- Ong K. K. (Ken K.)
- Padmanabhan S. (Sandosh)
- Palmer L. J. (Lyle J.)
- Pasko D. (Dorota)
- Paternoster L. (Lavinia)
- Pedersen O. (Oluf)
- Penninx B. W. (Brenda W. J. H.)
- Perez J. (Jeremiah)
- Perola M. (Markus)
- Perusse L. (Louis)
- Peters A. (Annette)
- Peters U. (Ulrike)
- Peyrot W. J. (Wouter J.)
- Peyser P. A. (Patricia A.)
- Polasek O. (Ozren)
- Porteous D. J. (David J.)
- Prokopenko I. (Inga)
- Puolijoki H. (Hannu)
- Qi L. (Lu)
- Qi Q. (Qibin)
- Quaye L. (Lydia)
- Raitakari O. T. (Olli T.)
- Rankinen T. (Tuomo)
- Rasmussen-Torvik L. J. (Laura J.)
- Rauramaa R. (Rainer)
- Rawal R. (Rajesh)
- Renstrom F. (Frida)
- Ridker P. M. (Paul M.)
- Rivadeneira F. (Fernando)
- Rivera N. V. (Natalia V.)
- Rose L. M. (Lynda M.)
- Rudan I. (Igor)
- Salomaa V. (Veikko)
- Sanna S. (Serena)
- Sarti C. (Cinzia)
- Sarzynski M. A. (Mark A.)
- Savonen K. (Kai)
- Scott R. A. (Robert A.)
- Scott W. R. (William R.)
- Shuldiner A. R. (Alan R.)
- Sidney S. (Steve)
- Silbernagel G. (Guenther)
- Smith A. V. (Albert Vernon)
- Smith B. H. (Blair H.)
- Smith G. D. (George Davey)
- Smith J. A. (Jennifer A.)
- Snieder H. (Harold)
- Snitker S. (Soren)
- Sorensen T. I. (Thorkild I. A.)
- Stancakova A. (Alena)
- Sternfeld B. (Barbara)
- Strachan D. P. (David P.)
- Strauch K. (Konstantin)
- Stringham H. M. (Heather M.)
- Swift A. J. (Amy J.)
- Tammelin T. (Tuija)
- Tan S.-T. (Sian-Tsung)
- Tanaka T. (Toshiko)
- Teumer A. (Alexander)
- Thorand B. (Barbara)
- Thuillier D. (Dorothee)
- Toenjes A. (Anke)
- Tuomilehto J. (Jaakko)
- Uitterlinden A. G. (Andre G.)
- Van der Most P. J. (Peter J.)
- van Duijn C. M. (Cornelia M.)
- van Grootheest G. (Gerard)
- van Vliet-Ostaptchouk J. V. (Jana V.)
- Vandenput L. (Liesbeth)
- Vestergaard H. (Henrik)
- Vitart V. (Veronique)
- Voelker U. (Uwe)
- Voelzke H. (Henry)
- Vohl M.-C. (Marie-Claude)
- Vollenweider P. (Peter)
- Waeber G. (Gerard)
- Walker M. (Mark)
- Wareham N. J. (Nicholas J.)
- Weir D. R. (David R.)
- Whitfield J. B. (John B.)
- Wild S. (Sarah)
- Willemsen G. (Gonneke)
- Wilson J. F. (James F.)
- Winkler T. W. (Thomas W.)
- Wong A. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A. F. (Alan F.)
- Wu Y. (Ying)
- Xue L. (Luting)
- Yengo L. (Loic)
- Young K. L. (Kristin L.)
- Zhang W. (Weihua)
- Zhao J. H. (Jing Hua)
- Zhao W. (Wei)
- Zillikens M. C. (M. Carola)
- Zubair N. (Niha)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery
The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
- Author
- Agraz Pamplona Irene
- Al Jayyousi Reem
- Alberici Federico
- Amin Tania
- Andrews Jacqueline
- Anton Jordi
- Arndt Fabian
- Atsumi Tatsuya
- Au Peh Chen
- Augusto Jean-Francois
- Baines Laura Anne
- Barbour Sean
- Barrio Lucia Vicente
- Becvar Radim
- Bekker Pirow
- Belilos Elise
- Belot Alexandre
- Benck Urs Tobias
- Bergner Raoul
- Bomback Andrew S.
- Bovy Christophe
- Brachemi Soumeya
- Brogan Paul
- Bruchfeld Annette
- Brunetta Enrico
- Burnier Michel
- Burton James
- Busch Martin
- Carlin Jeffrey
- Chakera Aron
- Chang Chen Lin Yih
- Chauveau Dominique
- Chester Wasko Mary
- Chua Ignatius
- Ciggaran Secundino
- Cinta Cid Maria
- Clarkson Michael
- Collins Michael
- Cooper Bruce
- Cornec Divi
- Cournoyer Serge
- Dagna Lorenzo
- Daikeler Thomas
- Dasgupta Bhaskar
- De Vita Salvatore
- de Zoysa Janak
- Demoulin Nathalie
- Derebail Vimal K.
- Diaz Encarnacion Montserrat
- Dieperink Hans
- Dobashi Hiroaki
- Doulton Timothy William Ronald
- Dragoi Serban
- Dua Anisha
- Dudler Jean
- Emmi Giacomo
- Ficheux Maxence
- Floege Juergen
- Flossmann Oliver
- Forbess Lindsy
- Fujimoto Shoichi
- Fulladosa Oliveras Xavier
- Gabrielli Armando
- Garibotto Giacomo
- Geetha Duvuru
- Gipson Patrick
- Girard Louis-Philippe
- Gohh Reginald
- Greenwood Gregory Todd
- Gregersen Jon Waarst
- Grevbo Bard-Waldum
- Griffin Sian V.
- Grundmann Franziska
- Hagino Noboru
- Halbritter Jan
- Haller Hermann
- Harigai Masayoshi
- Harper Janice Marian
- Harper Lorraine
- Haubitz Marion
- Hauser Thomas
- Hellemans Rachel
- Hellmich Bernhard
- Henes Joerg Christoph
- Hohenstein Bernd
- Horak Pavel
- Horomanski Audra
- Hougardy Jean-Michel
- Hugenberg Steven T.
- Hugo Christian
- Ihata Atsushi
- Iking-Konert Christof
- Ivarsen Per
- Jayne David R W
- Jimenez Richard A. H.
- Jose Soler Maria
- Jourde-Chiche Noemie
- Kalstad Synove
- Kaname Shinya
- Kaneko Yuko
- Karras Alexandre
- Kaskas Marwan Omar
- Katagiri Akira
- Katayama Masao
- Kermani Tanaz
- Kidder Dana
- Kirino Yohei
- Kitagawa Kiyoki
- Kivitz Alan J.
- Klein Alexandre
- Klocke Rainer
- Koening Curry
- Komatsuda Atsushi
- Kono Hajime
- Kotter Ina
- Krarup Elizabeth
- Kronbichler Andreas
- Kubacki T
- Kurasawa Takahiko
- Kurtkoti Jagadeesh
- Lamprecht Peter
- Langford Carol A.
- Langguth Daman
- Lanyon Peter Charles
- Laurin Louis-Philippe
- Levidiotis Vicki
- Lhotta Karl
- Liang Patrick
- Lindner Tom
- Little Mark
- Luqmani Raashid
- Luxton Grant
- Lyngsoe Cecilie
- Makanjuola David Osagie
- Manenti Lucio
- Marco Rusinol Helena
- Marder Galina
- Matsumura Ryutaro
- Maurier Francois
- McCann Liza
- McLaren John Stuart
- Mehling Heidrun
- Merkel Peter A
- Mesbah Rafik
- Mimura Toshihide
- Mohamed Amr Ahmed El-Huesseini
- Molloy Eamonn
- Monach Paul
- Moranne Olivier
- Morinobu Akio
- Mount Peter
- Mudge David
- Murakawa Yohko
- Nandagudi Anupama C.
- Naniwa Taio
- Nanki Toshihiro
- Neel Antoine
- Neumann Thomas
- Neyra Nilda Roxana
- Niemer Gregory W.
- Niles John
- Noble Euan
- O'Riordan Edmond
- Obi Reginald
- Ogawa Noriyoshi
- Oshima Hisaji
- Owens Charles
- Pagnoux Christian
- Parks Deborah L.
- Patel Mumtaz
- Patel Rajan Kantilal
- Philibert David
- Phoon Richard
- Pieruzzi Federico
- Podoll Amber S.
- Praga Manuel
- Pusey Charles Dickson
- Quemeneur Thomas
- Quintana Porras Luis
- Rabindranath Kannaiyan
- Rajakariar Ravindra
- Ranganathan Dwarakanathan
- Rigothier Claire
- Ritchie Angus
- Robson Joanna C.
- Robson Michael
- Roccatello Dario
- Rosenkranz Alexander
- Rovin Brad
- Rutgers Abraham
- Ryan Jessica
- Rychlik Ivan
- Saadoun David
- Sada Kenei
- Salama Alan David
- Salvarani Carlo
- Sam R
- Schaier Matthias
- Schönermarck Ulf
- Seeger Harald
- Segarra Alfons
- Segelmark Marten
- Selvan Shilpa
- Shergy William Julius
- Silva Arnold Lawrence
- Smyth Lucy
- Soveri Inga
- Specks Ulrich
- Spiera Robert
- Sprangers Ben
- Springer Jason M.
- Sreih Antonie G.
- Strand Vibeke
- Striebich Christopher Charles
- Sugiyama Eiji
- Suranyi Michael
- Svensson My Hanna Sofia
- Swarup Areena
- Sznajd Jan
- Szombati Istvan
- Szpirt Wladimir
- Szucs Gabriella
- Takeuchi Tohru
- Taki Hirofumi
- Tamura Naoto
- Taylor Joanne
- Teng Y. K. Onno
- Terrier Benjamin
- Tesar Vladimir
- Thakar Surabhi
- Thomaidi Eleni
- Tiliakos Athan N.
- Tsai Yong
- Tsukamoto Tatsuo
- van Daele Paulus Leon Arthur
- Venhoff Nils
- Vielhauer Volker
- Vogt Bruno
- Waguespack Dia R.
- Walker Robert
- Walsh Michael
- Westman Kerstin
- Wissing Karl Martin
- Witzke Oliver
- Yamagata Kunihiro
- Yamamura Masahiro
- Yue Huibin
- Zaoui Philippe
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rivaroxaban with or without aspirin in stable cardiovascular disease
- Author
- Abat M.
- Abatello M.
- Abdul Hafidz M. I.
- Abdul Rahim A. A.
- Abdullah W. M.
- Abe H.
- Abe M.
- Abe S.
- Abe Y.
- Abelson M.
- Abergel H.
- Abib E.
- Abitbul A.
- Abola M.
- Aboyans V.
- Abrantes J.
- Absi F.
- Abu Hassan M. R.
- Abu Kassim Z.
- Accassat S.
- Accini Diaz A.
- Accini Mendoza A.
- Accini Mendoza J.
- Acimic C.
- Acosta G.
- Actis M.
- Adamkova V.
- Adamo M.
- Adams K.
- Adler F.
- Agardi I.
- Agudelo Ramos L.
- Aguirre M.
- Agullo A.
- Ahmad H.
- Ahmed A.
- Ahuad Calvelo A.
- Ahuad Calvelo J.
- Ahuad Guerrero R.
- Aizawa Y.
- Ajax K.
- Akatsuka T.
- Akatsuka Y.
- Akhavuz O.
- Akiyama R.
- Akiyoshi H.
- Ako J.
- Al-Khalili F.
- Al-Qoofi F.
- Alagban C.
- Alarcon J.
- Alarcon V.
- Alarie P.
- Albertijn S.
- Albertsson P.
- Albisu Di Gennero J.
- Alcaraz J.
- Alcaraz L.
- Alcorano J.
- Ali I.
- Alianza M.
- Alings M.
- Alison M.
- Allegrini E.
- Almagro S.
- Almendrales L.
- Almroth H.
- Aloisi A.
- Alvarez D'Amelio A.
- Alvarez Damelio A.
- Alvarez M.
- Alvarez Y.
- Alwi S. M.
- Alzate J.
- Aman S.
- Amemiya H.
- Amemiya Y.
- Amerena J.
- Amir M. A.
- Amiya R.
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
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- Aldridge J.
- Aleagha Afshar Etemadi
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
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- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
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- Bruno Franco Mazza
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- Dk Maizatul Aiman B Pg Hj Ismail
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- Donall O'Croinin
- Donatella Mestria
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- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
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- Elaine Ferreira
- Eldar Søreide
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- Emre Erbabacan
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- Ferdinando Raimondi
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- Pilar Lora
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- Raquel Montoiro Allue
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- Stefania Aguirre
- Stella Metherell
- Stephanie Bell
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- Tanveer Hussain
- Tao Yu
- Taohidul Majid Taohid
- Tarek Dendane
- Tarikul Hamid
- Tasmin Patel
- Tatjana Simurina
- Teresa Honrubia
- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
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- Tomofumi Harasawa
- Tomoyuki Nakamura
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- Tracey Evans
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- Ugur Goktas
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- Upeka Samaranayake
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- Vanessa Linnett
- Vanessa M Sales
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- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status