Рациональный компромисс целей субъектов дистанционного образования

На базе системной методологии исследованы механизмы согласования деятельности субъектов в дистанционном образовании для нахождения рационального компромисса целей субъектов обучения, учебных заведений и агентов рынка труда. На схемах взаимосвязей компонентов системы образования в процессе обучения и на схеме взаимодействия учебных заведений проиллюстрированы преимущества такого подхода. Предложена математическая постановка задачи обеспечения рационального компромисса целей. Разработан алгоритм ее решения.На основі системної методології досліджено механізми погодження діяльності суб’єктів у дистанційній освіті з метою знаходження раціонального компромісу цілей суб’єктів навчання, навчальних закладів та агентів ринку праці. На схемах взаємозв’язків компонентів системи освіти у процесі навчання та на схемі взаємодії навчальних закладів проілюстровано переваги такого підходу. Запропоновано математичну модель задачі знаходження раціонального компромісу цілей та наведено алгоритм її розв’язку.Coordination mechanisms for agents purposes in the distance education have been studied on the basis of system methodology. The finding of rational compromise for purposes of learners, educational institutions and labour market agents is proposed. Benefits of the approach are illustrated by the scheme of education system components interconnection during the learning process and the scheme of educational institutions interaction. A mathematical model and an algorithm for finding the rational compromise of purposes are given

Лечение артериальной гипертензии в преклонном возрасте: от отрицания до признания необходимости

Представлен анализ результатов клинических исследований антигипертензивной терапии у пожилых пациентов, позволяющий сделать заключение о целесообразности ее проведения даже после достижения 80−летнего возраста.The analysis of the findings of clinical research of antihypertensive therapy in elderly patients, which allowed to conclude about the necessity about the expediency of its administration even in patients over 80, is presented

Bessel-Gauss beams of arbitrary integer order: propagation profile, coherence properties and quality factor

We present a novel approach to generate Bessel-Gauss modes of arbitrary integer order and well-defined optical angular momentum in a gradient index medium of transverse parabolic profile. The propagation and coherence properties, as well as the quality factor, are studied using algebraic techniques that are widely used in quantum mechanics. It is found that imposing the well-defined optical angular momentum condition, the Lie group $SU(1,1)$ comes to light as a characteristic symmetry of the Bessel-Gauss beams.Comment: 24 pages, 12 figure

CLDN4 (claudin-4)

Review on CLDN4 (claudin-4), with data on DNA, on the protein encoded, and where the gene is implicated

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment

Co-ordination and management of chronic conditions in Europe:the role of primary care.

Healthcare systems in Europe struggle with inadequate co-ordination of care for people with chronic conditions. Moreover, there is a considerable evidence gap in the treatment of chronic conditions, lack of self-management, variation in quality of care, lack of preventive care, increasing costs for chronic care, and inefficient use of resources. In order to overcome these problems, several approaches to improve the management and co-ordination of chronic conditions have been developed in European healthcare systems. These approaches endeavour to improve self-management support for patients, develop clinical information systems and change the organisation of health care. Changes in the delivery system design and the development of decision support systems are less common. Almost as a rule, the link between healthcare services and community resources and policies is missing. Most importantly, the integration between the six components of the chronic care model remains an important challenge for the future. We find that the position of primary care in healthcare systems is an important factor for the development and implementation of new approaches to manage and coordinate chronic conditions. Our analysis supports the notion that countries with a strong primary care system tend to develop more comprehensive models to manage and co-ordinate chronic conditions