81 research outputs found
Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Get PDFThe title molecule, C25H22F6N2O3, adopts an open conformation whereby the quinoline and carboxylate ester groups are orientated in opposite directions but to the same side of the piperidine ring so that the molecule has an approximate U-shape. The piperidine ring adopts a distorted boat conformation. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds generate R
2
2(14) loops
tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Get PDFThe title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)°. Helical supramolecular C(7) chains sustained by O—H⋯O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF3 groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7)
ChemInform Abstract: Diastereoselective Addition of Organomagnesium and Organolithium Reagents to Chiral Trifluoromethyl N-tert-Butanesulfinyl Hemiaminals.
No full textChemInform Abstract: Ring-Contracted Artemisinin Derivatives: Stereoselective Reaction of Anhydrodihydroartemisinin Towards Halogenating Reagents.
No full textChemInform Abstract: New Fused Dithiabicyclic Compounds from the Reaction of N,N-Dialkyl Perfluorothioamides with Allylmagnesium Halides.
No full textNew Three-Step Domino Reaction, “Thiophilic Addition—β-Elimination of Fluoride—[3,3] Sigmatropic Rearrangement”: Synthesis of α-Allylic and α,α-Bis(allylic) α-Trifluoromethyl Dithioesters.
No full textChemInform Abstract: Facile Conversion of Dithioesters into Carboxylic Acids or Esters Using Alkaline Hydrogen Peroxide.
No full text
Allylic Bromination of Anhydrodihydroartemisinin and of Its 10-Trifluoromethyl Analogue: A New Access to 16-Substituted Artemisinin Derivatives.
No full textEnantiopure Trifluoromethylated β<sup>3,3</sup>-Amino Acids: Synthesis by Asymmetric Reformatsky Reaction with Stable Analogues of Trifluoromethyl <i>N</i>-<i>tert</i>-Butanesulfinylketoimines and Incorporation into α/β-Peptides
No full textAddition of a Reformatsky reagent to α-aryl(alkyl)
α-trifluoromethyl <i>N</i>-<i>tert</i>-butanesulfinyl
hemiaminals, bench-stable
surrogates of trifluoromethyl ketoimines, provided β-alkyl(aryl)
β-trifluoromethyl β-amino acids derivatives in good yields
and high diastereoselectivities. The <i>N</i>-<i>tert</i>-butanesulfinyl β<sup>3,3</sup>-amino esters were further utilized
as versatile intermediates for the elaboration of heterodi- and -tripeptides
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