382 research outputs found

    Speech In, For, and By (?) the Multiversity : Reflections of a Recovering President

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    The Relationship between Cost Analysis and Program Management

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    Cost analysis if often viewed as applying basic principles and cost methodologies to determine total system cost. These finished estimates then flow into a decision making process and the cost estimator leaves the stage. Reality shows that the cost estimator is actually one of the main contributors to the decision making process. Our introduction to this special issue explores the areas where cost estimating plays a major role in program management in areas beyond the normal program estimate. We have included articles that show the key role estimators can play in source selection strategies and evaluation; cost of delay analysis for management decisions, earned value management methods to predict program costs; decision criteria to rank competing projects that complement traditional cost-based methods; and a new methodology for determining research and development budget profiles

    A Tribute to Thomas Headrick

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    Teaching Complex, In-Depth Programs

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    Changing demographics of rural Extension audiences create challenges to program delivery, and multiple delivery methods may be needed to effectively improve skills and knowledge of clients. We examined the effectiveness of different delivery methods and changes in client skills, knowledge and abilities as a result of a complex, in-depth program, the Virginia Cow/Calf Management Course. Almost 500 producers took the 5-month course. Changes were measured from pre- and post-course surveys. Skills easily employed by the producers were readily adopted. Experiential learning opportunities and written materials had the greatest impact on producers, while Web-based information and discussion groups were marginally effective

    Fast X-ray Transients and Their Connection to Gamma-Ray Bursts

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    Fast X-ray transients (FXTs) with timescales from seconds to hours have been seen by numerous space instruments. We have assembled archival data from Ariel-5, HEAO-1 (A-1 and A-2), WATCH, ROSAT, and Einstein to produce a global fluence-frequency relationship for these events. Fitting the log N-log S distribution over several orders of magnitude to simple power law we find a slope of -1.0. The sources of FXTs are undoubtedly heterogeneous, the -1 power law is an approximate result of the summation of these multiple sources. Two major contributions come from gamma-ray bursts and stellar flares. Extrapolating from the BATSE catalog of GRBs, we find that the fraction of X-ray flashes that can be the X-ray counterparts of gamma-ray bursts is a function of fluence. Certainly most FXTs are not counterparts of standard gamma-ray bursts. The fraction of FXTs from non-GRB sources, such as magnetic stars, is greatest for the faintest FXTs. Our understanding of the FXT phenomenon remains limited and would greatly benefit from a large, homogeneous data set, which requires a wide-field, sensitive instrument.Comment: 36 pages, 8 figure

    N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.

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    The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether N17 could be a molecular determinant of nuclear mHTT pathogenesis in vivo. BAC transgenic mice expressing mHTT lacking the N17 domain (BACHD-ΔN17) show dramatically accelerated mHTT pathology exclusively in the nucleus, which is associated with HD-like transcriptionopathy. Interestingly, BACHD-ΔN17 mice manifest more overt disease-like phenotypes than the original BACHD mice, including body weight loss, movement deficits, robust striatal neuron loss, and neuroinflammation. Mechanistically, N17 is necessary for nuclear exclusion of small mHTT fragments that are part of nuclear pathology in HD. Together, our study suggests that N17 modifies nuclear pathogenesis and disease severity in HD mice by regulating subcellular localization of known nuclear pathogenic mHTT species

    Calibration of the GLAST Burst Monitor detectors

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    The GLAST Burst Monitor (GBM) will augment the capabilities of GLAST for the detection of cosmic gamma-ray bursts by extending the energy range (20 MeV to > 300 GeV) of the Large Area Telescope (LAT) towards lower energies by 2 BGO-detectors (150 keV to 30 MeV) and 12 NaI(Tl) detectors (10 keV to 1 MeV). The physical detector response of the GBM instrument for GRBs is determined with the help of Monte Carlo simulations, which are supported and verified by on-ground calibration measurements, performed extensively with the individual detectors at the MPE in 2005. All flight and spare detectors were irradiated with calibrated radioactive sources in the laboratory (from 14 keV to 4.43 MeV). The energy/channel-relations, the dependences of energy resolution and effective areas on the energy and the angular responses were measured. Due to the low number of emission lines of radioactive sources below 100 keV, calibration measurements in the energy range from 10 keV to 60 keV were performed with the X-ray radiometry working group of the Physikalisch-Technische Bundesanstalt (PTB) at the BESSY synchrotron radiation facility, Berlin.Comment: 2 pages, 1 figure; to appear in the Proc. of the First Int. GLAST Symp. (Stanford, Feb. 5-8, 2007), eds. S.Ritz, P.F.Michelson, and C.Meegan, AIP Conf. Pro
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