1,314 research outputs found
The Interface of Work to Family Conflict and Racioethnic Identification: An Analysis of Hispanic Business Professionals
This article examines work to family conflict for Hispanic Business Professionals with varied levels of Hispanic identity. Based on this study of 971 Hispanics from across the United States, results show that level of Hispanic identity moderates the relationship between work to family conflict and job satisfaction. The authors posit that identification with a culture of collectivism may attenuate the negative impact of work to family conflict on job satisfaction, enabling Hispanic professionals to view work as a way of supporting the family and contributing to the greater good of the groups to which they belong
Responses to affect-eliciting stimuli: The roles of alexithymia and negative affect
Tables: [46]-[50]; Figure: [51]-[52]Thesis (B.S.) in Psychology--University of Illinois at Urbana-Champaign, 1992.Includes bibliographical references (leaves 42-45)Microfiche of typescript. [Urbana, Ill.]: Photographic Services, University of Illinois, U of I Library, [1992]. 2 microfiches (55 frames): negative.s 1992 ilu n
Roles of motor proteins in building microtubule-based structures: a basic principle of cellular design
AbstractEukaryotic cells must build a complex infrastructure of microtubules (MTs) and associated proteins to carry out a variety of functions. A growing body of evidence indicates that a major function of MT-associated motor proteins is to assemble and maintain this infrastructure. In this context, we examine the mechanisms utilized by motors to construct the arrays of MTs and associated proteins contained within the mitotic spindle, neuronal processes, and ciliary axonemes. We focus on the capacity of motors to drive the ‘sliding filament mechanism’ that is involved in the construction and maintenance of spindles, axons and dendrites, and on a type of particle transport called ‘intraflagellar transport’ which contributes to the assembly and maintenance of axonemes
Mitosis, microtubules, and the matrix
The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question
Inhibition of Liver Cytochrome P450 Isoforms 1A1 and 1A2 by Brazilian Acai Berry Extracts
Undergraduate
Basi
Economical routes to size-specific assembly of self-closing structures
Self-assembly is one of the prevalent strategies used by living systems to
fabricate ensembles of precision nanometer-scale structures and devices. The
push for analogous approaches to create synthetic nanomaterials has led to the
development of a large class of programmable crystalline structures. However,
many applications require `self-limiting' assemblies, which autonomously
terminate growth at a well-defined size and geometry. For example, curved
architectures such as tubules, vesicles, or capsids can be designed to
self-close at a particular size, symmetry, and topology. But developing
synthetic strategies for self-closing assembly has been challenging, in part
because such structures are prone to polymorphism that arises from thermal
fluctuations of their local curvature, a problem that worsens with increased
target size. Here we demonstrate a strategy to eliminate this source of
polymorphism in self-closing assembly of tubules by increasing the assembly
complexity. In the limit of single-component assembly, we find that thermal
fluctuations allow the system to assemble nearby, off-target structures with
varying widths, helicities, and chirality. By increasing the number of distinct
components, we reduce the density of off-target states, thereby increasing the
selectivity of a user-specified target structure to nearly 100%. We further
show that by reducing the design constraints by targeting either the pitch or
the width of tubules, fewer components are needed to reach complete
selectivity. Combining experiments with theory, our results reveal an
economical limit, which determines the minimum number of components that are
required to create arbitrary assembly sizes with full selectivity. In the
future, this approach could be extended to more complex self-limited
structures, such as shells or triply periodic surfaces.Comment: Main text 8 pages, 5 figures, SI 22 pages, 12 figures, 5 tables.
Slight changes to the text from previous versio
The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear. Genetic analyses have suggested an involvement for Skp/Cullin/F box (SCF)-class ubiquitin ligases in this process. In this study, we describe a mechanism to prevent centriole reduplication in Drosophila melanogaster whereby the SCF E3 ubiquitin ligase in complex with the F-box protein Slimb mediates proteolytic degradation of the centrosomal regulatory kinase Plk4. We identified SCFSlimb as a regulator of centriole duplication via an RNA interference (RNAi) screen of Cullin-based ubiquitin ligases. We found that Plk4 binds to Slimb and is an SCFSlimb target. Both Slimb and Plk4 localize to centrioles, with Plk4 levels highest at mitosis and absent during S phase. Using a Plk4 Slimb-binding mutant and Slimb RNAi, we show that Slimb regulates Plk4 localization to centrioles during interphase, thus regulating centriole number and ensuring the block to centriole reduplication
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