Cadence and range of motion modulate pedal force in a rat model of motorized cycling after spinal cord injury.

Motorized cycling (MC) can be utilized post-spinal cord injury (SCI) in patients who lack the strength and/or stability to participate in traditional physical exercise interventions. MC has been applied with the goal of improving locomotor function or cardiovascular health in both human and animal models of SCI. However, a discrepancy exists between the results of human and animal studies of MC, particularly regarding cardiovascular outcomes. Despite the abundance of studies in both humans and animals, the mechanism behind the improvements in cardiovascular function following MC are poorly understood. We posited that increased venous return during MC is likely due to the skeletal muscle pump, where muscle activity during MC would be triggered by stretch reflexes. As stretch reflexes are dependent on both rate and length of muscle stretch, we hypothesized that cycling cadence and crank length could modulate muscle activity and therefore hindlimb loading during cycling. Initial studies testing the development of the instrumented pedals noted spasticity that was represented in the force traces, and a filtering technique was developed to separate spastic from non-spastic forces. Results using this technique combined with EMG of a knee flexor and extensor suggest that higher cadences (≥30 RPM) increased RMS EMG and non-spastic forces, while lower cadences (≤15 RPM) increased spastic forces. Furthermore, large spastic events were associated with a decrease in BP, while high cadence cycling with limited spasticity appeared to elevate BP and HR above baseline levels. These results suggest that MC in rats may constitute a mild eccentric training regimen; clinical translation may therefore be dependent on the ability to reflexively generate muscle contraction in patients during cycling

Recounting Dyons in N=4 String Theory

A recently discovered relation between 4D and 5D black holes is used to derive weighted BPS black hole degeneracies for 4D N=4 string theory from the well-known 5D degeneracies. They are found to be given by the Fourier coefficients of the unique weight 10 automorphic form of the modular group Sp(2,Z). This result agrees exactly with a conjecture made some years ago by Dijkgraaf, Verlinde and Verlinde.Comment: 5 page

Habitat complexity and food item size modify the foraging behaviour of a freshwater fish

The functional response describes the relationship between feeding rate and prey density, and is important ecologically as it describes how foraging behaviour may change in response to food availability. The effects of habitat complexity and food item size were experimentally tested on the foraging parameters and functional responses of the freshwater fish roach Rutilus rutilus. Habitat complexity was varied through the manipulation of substrate and turbidity, and food item size was varied by using fishmeal pellets in two sizes. As water turbidity and substrate complexity increased, the reaction distance and consumption rate (per number) significantly decreased. Increased food item size significantly decreased consumption rates (per number) but had no influence on any other foraging parameter. Analysis of the interactions between substrate complexity, turbidity and food item size revealed food item size had the greatest influence on consumption rate (per number). Turbidity had the least effect on all the foraging parameters tested. Across all experiments, the functional responses were best described by the Type II response, a relatively consistent finding for R. rutilus. These outputs reveal that fish foraging behaviours and functional responses are highly context dependent, varying with environmental parameters and the availability of food resources of different sizes

Association between symptoms of sleep apnea and problem behaviors in young adult twins and siblings

Background: Sleep apnea is one of the most common sleep disorders and it is related to multiple negative health consequences. Previous studies have shown that sleep apnea is influenced by genetic factors. However, studies have not investigated the genetic and environmental influences of symptoms of sleep apnea in young adults. Furthermore, the underpinnings of the relationship between apnea symptoms and internalizing/externalizing problems are unknown. The objectives of this study were to estimate the magnitude of: 1) genetic and environmental influences on self-reported apnea symptoms; 2) the relationship between self-reported apnea symptoms and internalizing/externalizing traits; 3) genetic and environmental influences on the associations between self-reported apnea symptoms, internalizing behaviors and externalizing behaviors. Methods: In a twin/sibling study, univariate and multivariate models were fitted to estimate both individual variance and sources of covariance between symptoms of sleep apnea and internalizing/externalizing behaviors. Results: Our results show that genetic influences account for 40% the variance in sleep apnea symptoms. Moreover, there are modest associations between depression, anxiety and externalizing behaviors with apnea symptoms (ranging from r = .22 to .29). However, the origins of these associations differ. For example, whereas most of the covariation between symptoms of depression and sleep apnea can be explained by genes (95%), there was a larger role for the environment (53%) in the association between symptoms of anxiety and sleep apnea. Conclusions: Genetic factors explain a significant proportion of variance in symptoms of apnea and most of the covariance with depression

Dilatonic global strings

We examine the field equations of a self-gravitating global string in low energy superstring gravity, allowing for an arbitrary coupling of the global string to the dilaton. Massive and massless dilatons are considered. For the massive dilaton the spacetime is similar to the recently discovered non-singular time-dependent Einstein self-gravitating global string, but the massless dilaton generically gives a singular spacetime, even allowing for time-dependence. We also demonstrate a time-dependent non-singular string/anti-string configuration, in which the string pair causes a compactification of two of the spatial dimensions, albeit on a very large scale.Comment: 18 pages RevTeX, 3 figures, references amende

Localized Tachyons and the Quantum McKay Correspondence

The condensation of closed string tachyons localized at the fixed point of a C^d/\Gamma orbifold can be studied in the framework of renormalization group flow in a gauged linear sigma model. The evolution of the Higgs branch along the flow describes a resolution of singularities via the process of tachyon condensation. The study of the fate of D-branes in this process has lead to a notion of a ``quantum McKay correspondence.'' This is a hypothetical correspondence between fractional branes in an orbifold singularity in the ultraviolet with the Coulomb and Higgs branch branes in the infrared. In this paper we present some nontrivial evidence for this correspondence in the case C^2/Z_n by relating the intersection form of fractional branes to that of ``Higgs branch branes,'' the latter being branes which wrap nontrivial cycles in the resolved space.Comment: 25 pages; harvma

Influence of environmental and biological factors on the overwinter growth rate of Atlantic salmon Salmo salar parr in a UK chalk stream

Smolt lengths are increasingly recognised as an important determinant of salmonid marine survival rates. Overwintering growth rates could thus strongly influence adult return rates. In Atlantic salmon Salmo salar, most overwintering studies focus on rivers in harsh climates with minimal growth, yet in more southerly rivers, overwintering growth rates can be relatively high. Here, the factors influencing annual overwinter growth rates were tested for juvenile S. salar in a temperate chalk stream in southern England over 13 years, where over 10,000 salmon parr were tagged annually in autumn and a proportion recaptured the following spring during smolt emigration. Winters of higher and more variable water temperatures, with longer periods of high flows, showed increased overwintering growth rates. Faster growth rates were recorded from sites further upstream and that had lower parr densities; smaller individuals also grew more than expected for their initial size. These results suggest that a range of factors influences overwintering salmonid growth rates and can be used to inform management decisions to maximise the quality of emigrating smolts

Core Structure of Global Vortices in Brane World Models

We study analytically and numerically the core structure of global vortices forming on topologically deformed brane-worlds with a single toroidally compact extra dimension. It is shown that for an extra dimension size larger than the scale of symmetry breaking the magnitude of the complex scalar field at the vortex center can dynamically remain non-zero. Singlevaluedness and regularity are not violated. Instead, the winding escapes to the extra dimension at the vortex center. As the extra dimension size decreases the field magnitude at the core dynamically decreases also and in the limit of zero extra dimension size we reobtain the familiar global vortex solution. Extensions to other types of defects and gauged symmetries are also discussed.Comment: 6 two column pages, 3 figure

Atlantic salmon return rate increases with smolt length

Recent declines in Atlantic salmon Salmo salar populations are generally attributed to factors in their marine life-phase. However, it is postulated that factors affecting their freshwater life-phase might impact their marine survival, such as the influence of body size. While larger smolts are widely hypothesized to have higher marine survival rates, empirical support remains scant, in part due to inadequate data and ambiguous statistical analyses. Here, we test the influence of smolt body size on marine return rates, a proxy for marine survival, using a 12-year dataset of 3688 smolts tagged with passive integrated transponders in the River Frome, Southern England. State-space models describe the probability of smolts surviving their marine phase to return as 1 sea-winter (1SW) or multi-sea-winter adults as a function of their length, while accounting for imperfect detection and missing data. Models predicted that larger smolts had higher return rates; the most parsimonious model included the effect of length on 1SW return rate. This prediction is concerning, as freshwater juvenile salmon are decreasing in size on the River Frome, and elsewhere. Thus, to maximize adult returns, restoration efforts should focus on freshwater life-stages, and maximize both the number and the size of emigrating smolts

Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds

The patterning of neuronal cells and guiding neurite growth are important for neuron tissue engineering and cell-based biosensors. In this paper, inkjet printing has been employed to pattern self-assembled I3QGK peptide nanofibers on silk substrates for guiding the growth of neuron-like PC12 cells. Atomic force microscopy (AFM) confirmed the dynamic self-assembly of I3QGK into nanofiber structures. The printed self-assembled peptide strongly adheres to regenerated silk fibroin (RSF) substrates through charge-charge interactions. It was observed that in the absence of I3QGK, PC12 cells exhibited poor attachment to RSF films, while for RSF surfaces coated or printed with peptide nanofibers, cellular attachment was significantly improved in terms of both cell density and morphology. AFM results revealed that peptide nanofibers can promote the generation of axons and terminal buttons of PC12 cells, indicating that I3QGK nanofibers not only promote cellular attachment but also facilitate differentiation into neuronal phenotypes. Inkjet printing allows complex patterning of peptide nanofibers onto RSF substrates, which enabled us to engineer cell alignment and provide an opportunity to direct axonal development in vitro. The live/dead assay showed that printed I3QGK patterns exhibit no cytotoxicity to PC12 cells demonstrating potential for future nerve tissue engineering applications